Association between the methyl-CpG-binding domain protein 5 gene and depressive symptoms in a Mexican population: results from the MxGDAR/Encodat cohort
Objective: To explore the association of 75 candidate genes previously reported in subjects with anxiety symptoms (AS) and depressive symptoms (DS) with such symptomatology in a Mexican cohort. Methods: The sample included 2,012 individuals from the Mexican Genomic Database for Addiction Research...
Saved in:
| Main Authors: | , , , , , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Associação Brasileira de Psiquiatria (ABP)
2025-06-01
|
| Series: | Brazilian Journal of Psychiatry |
| Subjects: | |
| Online Access: | http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1516-44462025000100217&lng=en&tlng=en |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
| _version_ | 1849689830379749376 |
|---|---|
| author | Marco Antonio Sanabrais-Jiménez Beatriz Camarena Alejandro Aguilar-García Alma Delia Genis-Mendoza José Jaime Martínez-Magaña Humberto Nicolini Jorge Ameth Villatoro-Velázquez Marycarmen Bustos-Gamiño María de Lourdes Gutiérrez-López María Elena Medina-Mora |
| author_facet | Marco Antonio Sanabrais-Jiménez Beatriz Camarena Alejandro Aguilar-García Alma Delia Genis-Mendoza José Jaime Martínez-Magaña Humberto Nicolini Jorge Ameth Villatoro-Velázquez Marycarmen Bustos-Gamiño María de Lourdes Gutiérrez-López María Elena Medina-Mora |
| author_sort | Marco Antonio Sanabrais-Jiménez |
| collection | DOAJ |
| description | Objective: To explore the association of 75 candidate genes previously reported in subjects with anxiety symptoms (AS) and depressive symptoms (DS) with such symptomatology in a Mexican cohort. Methods: The sample included 2,012 individuals from the Mexican Genomic Database for Addiction Research (MxGDAR/Encodat) cohort: 198 with AS, 266 with DS, 66 with both anxiety and depressive symptoms (ADS), and 1,482 healthy controls. The Diagnostic Interview for Psychosis and Affective Disorders (DI-PAD) screening questionnaire was used to evaluate lifetime AS and DS. The sample was genotyped with the commercial microarray PsychArray BeadChip. We identified 707 single nucleotide polymorphisms (SNPs) of 75 genes previously associated with AS and DS. The PLINK logistic regression approach was performed to analyze the association between these SNPs and AS, DS, and ADS. Results: The analysis identified significant associations of LAMA SNP rs2437092 (p = 3.89 × 10-5) and MYO1H SNP rs11066591 (p = 4.06 × 10-5) with anxiety and depressive symptoms. Additionally, MBD5 SNPs rs7578002 and rs1234428 were associated with DS (p = 7.9 × 10-6 and p = 1.94 × 10-5, respectively). However, after adjustment for age, sex, and the three genetic principal components, only the associations of rs7578002 and rs1234428 with DS remained (p = 5.85 × 10-5 and p = 8.15 × 10-5, respectively). Conclusions: Our study replicated the association between MBD5 and DS. The MBD5 protein is involved in gene silencing, suggesting its potential implication in the development of DS in the Mexican population. |
| format | Article |
| id | doaj-art-9ef3eb186bc74dbe826f405ca12565b1 |
| institution | DOAJ |
| issn | 1809-452X |
| language | English |
| publishDate | 2025-06-01 |
| publisher | Associação Brasileira de Psiquiatria (ABP) |
| record_format | Article |
| series | Brazilian Journal of Psychiatry |
| spelling | doaj-art-9ef3eb186bc74dbe826f405ca12565b12025-08-20T03:21:30ZengAssociação Brasileira de Psiquiatria (ABP)Brazilian Journal of Psychiatry1809-452X2025-06-014710.47626/1516-4446-2024-3859Association between the methyl-CpG-binding domain protein 5 gene and depressive symptoms in a Mexican population: results from the MxGDAR/Encodat cohortMarco Antonio Sanabrais-Jiménezhttps://orcid.org/0000-0002-7722-5940Beatriz Camarenahttps://orcid.org/0000-0001-7737-501XAlejandro Aguilar-GarcíaAlma Delia Genis-Mendozahttps://orcid.org/0000-0001-8180-477XJosé Jaime Martínez-Magañahttps://orcid.org/0000-0003-0390-8252Humberto Nicolinihttps://orcid.org/0000-0003-2494-0067Jorge Ameth Villatoro-Velázquezhttps://orcid.org/0000-0003-2537-858XMarycarmen Bustos-GamiñoMaría de Lourdes Gutiérrez-LópezMaría Elena Medina-Mora Objective: To explore the association of 75 candidate genes previously reported in subjects with anxiety symptoms (AS) and depressive symptoms (DS) with such symptomatology in a Mexican cohort. Methods: The sample included 2,012 individuals from the Mexican Genomic Database for Addiction Research (MxGDAR/Encodat) cohort: 198 with AS, 266 with DS, 66 with both anxiety and depressive symptoms (ADS), and 1,482 healthy controls. The Diagnostic Interview for Psychosis and Affective Disorders (DI-PAD) screening questionnaire was used to evaluate lifetime AS and DS. The sample was genotyped with the commercial microarray PsychArray BeadChip. We identified 707 single nucleotide polymorphisms (SNPs) of 75 genes previously associated with AS and DS. The PLINK logistic regression approach was performed to analyze the association between these SNPs and AS, DS, and ADS. Results: The analysis identified significant associations of LAMA SNP rs2437092 (p = 3.89 × 10-5) and MYO1H SNP rs11066591 (p = 4.06 × 10-5) with anxiety and depressive symptoms. Additionally, MBD5 SNPs rs7578002 and rs1234428 were associated with DS (p = 7.9 × 10-6 and p = 1.94 × 10-5, respectively). However, after adjustment for age, sex, and the three genetic principal components, only the associations of rs7578002 and rs1234428 with DS remained (p = 5.85 × 10-5 and p = 8.15 × 10-5, respectively). Conclusions: Our study replicated the association between MBD5 and DS. The MBD5 protein is involved in gene silencing, suggesting its potential implication in the development of DS in the Mexican population.http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1516-44462025000100217&lng=en&tlng=enDepressive symptomsanxiety symptomsMBD5 |
| spellingShingle | Marco Antonio Sanabrais-Jiménez Beatriz Camarena Alejandro Aguilar-García Alma Delia Genis-Mendoza José Jaime Martínez-Magaña Humberto Nicolini Jorge Ameth Villatoro-Velázquez Marycarmen Bustos-Gamiño María de Lourdes Gutiérrez-López María Elena Medina-Mora Association between the methyl-CpG-binding domain protein 5 gene and depressive symptoms in a Mexican population: results from the MxGDAR/Encodat cohort Brazilian Journal of Psychiatry Depressive symptoms anxiety symptoms MBD5 |
| title | Association between the methyl-CpG-binding domain protein 5 gene and depressive symptoms in a Mexican population: results from the MxGDAR/Encodat cohort |
| title_full | Association between the methyl-CpG-binding domain protein 5 gene and depressive symptoms in a Mexican population: results from the MxGDAR/Encodat cohort |
| title_fullStr | Association between the methyl-CpG-binding domain protein 5 gene and depressive symptoms in a Mexican population: results from the MxGDAR/Encodat cohort |
| title_full_unstemmed | Association between the methyl-CpG-binding domain protein 5 gene and depressive symptoms in a Mexican population: results from the MxGDAR/Encodat cohort |
| title_short | Association between the methyl-CpG-binding domain protein 5 gene and depressive symptoms in a Mexican population: results from the MxGDAR/Encodat cohort |
| title_sort | association between the methyl cpg binding domain protein 5 gene and depressive symptoms in a mexican population results from the mxgdar encodat cohort |
| topic | Depressive symptoms anxiety symptoms MBD5 |
| url | http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1516-44462025000100217&lng=en&tlng=en |
| work_keys_str_mv | AT marcoantoniosanabraisjimenez associationbetweenthemethylcpgbindingdomainprotein5geneanddepressivesymptomsinamexicanpopulationresultsfromthemxgdarencodatcohort AT beatrizcamarena associationbetweenthemethylcpgbindingdomainprotein5geneanddepressivesymptomsinamexicanpopulationresultsfromthemxgdarencodatcohort AT alejandroaguilargarcia associationbetweenthemethylcpgbindingdomainprotein5geneanddepressivesymptomsinamexicanpopulationresultsfromthemxgdarencodatcohort AT almadeliagenismendoza associationbetweenthemethylcpgbindingdomainprotein5geneanddepressivesymptomsinamexicanpopulationresultsfromthemxgdarencodatcohort AT josejaimemartinezmagana associationbetweenthemethylcpgbindingdomainprotein5geneanddepressivesymptomsinamexicanpopulationresultsfromthemxgdarencodatcohort AT humbertonicolini associationbetweenthemethylcpgbindingdomainprotein5geneanddepressivesymptomsinamexicanpopulationresultsfromthemxgdarencodatcohort AT jorgeamethvillatorovelazquez associationbetweenthemethylcpgbindingdomainprotein5geneanddepressivesymptomsinamexicanpopulationresultsfromthemxgdarencodatcohort AT marycarmenbustosgamino associationbetweenthemethylcpgbindingdomainprotein5geneanddepressivesymptomsinamexicanpopulationresultsfromthemxgdarencodatcohort AT mariadelourdesgutierrezlopez associationbetweenthemethylcpgbindingdomainprotein5geneanddepressivesymptomsinamexicanpopulationresultsfromthemxgdarencodatcohort AT mariaelenamedinamora associationbetweenthemethylcpgbindingdomainprotein5geneanddepressivesymptomsinamexicanpopulationresultsfromthemxgdarencodatcohort |