The Evaluation of Memantine Effect on Tinnitus Severity
ABSTRACT Purpose Tinnitus is a common condition where a person perceives sound despite there being no external auditory stimuli. It is proven that overexpression of NMDA (N‐methyl‐d‐aspartate) glutamate receptors increases the sensitivity of neurons to glutamate transmission, creating a destructive...
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| Format: | Article |
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Wiley
2025-07-01
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| Series: | Brain and Behavior |
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| Online Access: | https://doi.org/10.1002/brb3.70697 |
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| author | Babak Pourayyoubi Alireza Rezaei‐Ashtiani Javad Javaheri Mohsen Ebrahimi Monfared Farzad Zamani |
| author_facet | Babak Pourayyoubi Alireza Rezaei‐Ashtiani Javad Javaheri Mohsen Ebrahimi Monfared Farzad Zamani |
| author_sort | Babak Pourayyoubi |
| collection | DOAJ |
| description | ABSTRACT Purpose Tinnitus is a common condition where a person perceives sound despite there being no external auditory stimuli. It is proven that overexpression of NMDA (N‐methyl‐d‐aspartate) glutamate receptors increases the sensitivity of neurons to glutamate transmission, creating a destructive cycle of excitotoxicity. NMDA receptor antagonists, such as memantine, seem to be effective in treating tinnitus. This study aimed to examine the effectiveness of memantine as a treatment for tinnitus in a double‐blind randomized placebo control clinical trial. Methods The participants were patients with tinnitus. A total of 70 patients were randomly assigned into two groups, intervention and a placebo, with an equal number of patients in each group. Both groups received conventional treatment with cinnarizine at a dose of 25 mg twice a day. In the intervention group, memantine was added to cinnarizine with starting dose of 5 mg. Tinnitus Severity Index (TSI) and Numeric Rating Scale (NRS) were recorded before and after study in both groups. Findings There was no significant difference in the initial mean of NRS and TSI scores between two groups. After treatment, the mean NRS and TSI scores were significantly lower in the intervention group. Although the changes in mean NRS scores were significant in both groups at the end of study but only the mean TSI scores were significantly decreased in the intervention group. Conclusion On the basis of these findings, it is suggested that memantine may have remarkable effect in reducing tinnitus and its discomfort. |
| format | Article |
| id | doaj-art-9ef1ac0afdb24adca25f910bb68e08b2 |
| institution | DOAJ |
| issn | 2162-3279 |
| language | English |
| publishDate | 2025-07-01 |
| publisher | Wiley |
| record_format | Article |
| series | Brain and Behavior |
| spelling | doaj-art-9ef1ac0afdb24adca25f910bb68e08b22025-08-20T03:09:00ZengWileyBrain and Behavior2162-32792025-07-01157n/an/a10.1002/brb3.70697The Evaluation of Memantine Effect on Tinnitus SeverityBabak Pourayyoubi0Alireza Rezaei‐Ashtiani1Javad Javaheri2Mohsen Ebrahimi Monfared3Farzad Zamani4Student Research Committee, School of Medicine Arak University of Medical Sciences Arak IranDepartment of Neurology, School of Medicine Arak University of Medical Sciences Arak IranDepartment of Community Medicine, School of Medicine Arak University of Medical Sciences Arak IranDepartment of Neurology, School of Medicine Arak University of Medical Sciences Arak IranDepartment of Otorhinolaryngology, School of Medicine Arak University of Medical Sciences Arak IranABSTRACT Purpose Tinnitus is a common condition where a person perceives sound despite there being no external auditory stimuli. It is proven that overexpression of NMDA (N‐methyl‐d‐aspartate) glutamate receptors increases the sensitivity of neurons to glutamate transmission, creating a destructive cycle of excitotoxicity. NMDA receptor antagonists, such as memantine, seem to be effective in treating tinnitus. This study aimed to examine the effectiveness of memantine as a treatment for tinnitus in a double‐blind randomized placebo control clinical trial. Methods The participants were patients with tinnitus. A total of 70 patients were randomly assigned into two groups, intervention and a placebo, with an equal number of patients in each group. Both groups received conventional treatment with cinnarizine at a dose of 25 mg twice a day. In the intervention group, memantine was added to cinnarizine with starting dose of 5 mg. Tinnitus Severity Index (TSI) and Numeric Rating Scale (NRS) were recorded before and after study in both groups. Findings There was no significant difference in the initial mean of NRS and TSI scores between two groups. After treatment, the mean NRS and TSI scores were significantly lower in the intervention group. Although the changes in mean NRS scores were significant in both groups at the end of study but only the mean TSI scores were significantly decreased in the intervention group. Conclusion On the basis of these findings, it is suggested that memantine may have remarkable effect in reducing tinnitus and its discomfort.https://doi.org/10.1002/brb3.70697memantineNMDA receptorstinnitus |
| spellingShingle | Babak Pourayyoubi Alireza Rezaei‐Ashtiani Javad Javaheri Mohsen Ebrahimi Monfared Farzad Zamani The Evaluation of Memantine Effect on Tinnitus Severity Brain and Behavior memantine NMDA receptors tinnitus |
| title | The Evaluation of Memantine Effect on Tinnitus Severity |
| title_full | The Evaluation of Memantine Effect on Tinnitus Severity |
| title_fullStr | The Evaluation of Memantine Effect on Tinnitus Severity |
| title_full_unstemmed | The Evaluation of Memantine Effect on Tinnitus Severity |
| title_short | The Evaluation of Memantine Effect on Tinnitus Severity |
| title_sort | evaluation of memantine effect on tinnitus severity |
| topic | memantine NMDA receptors tinnitus |
| url | https://doi.org/10.1002/brb3.70697 |
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