Association of Hepatitis-B virus infection status with survival and treatment response in non-small cell lung cancer patients on anti‐pd‐1/pd-l1 therapy
AIM: HBV reactivation is a significant risk for cancer patients undergoing immunosuppressive or chemotherapy. However, since these patients are often excluded from immunotherapy trials, the safety of anti-PD-1 and anti-PD-L1 therapies in this context remains unclear. Recent advances in cancer treatm...
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| Language: | English |
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Elsevier
2024-12-01
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| Series: | Journal of Global Antimicrobial Resistance |
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| Online Access: | http://www.sciencedirect.com/science/article/pii/S2213716524004259 |
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| author | Eda Alp Goncagul Akdag Topal DENİZ IŞIK Nedim Turan |
| author_facet | Eda Alp Goncagul Akdag Topal DENİZ IŞIK Nedim Turan |
| author_sort | Eda Alp |
| collection | DOAJ |
| description | AIM: HBV reactivation is a significant risk for cancer patients undergoing immunosuppressive or chemotherapy. However, since these patients are often excluded from immunotherapy trials, the safety of anti-PD-1 and anti-PD-L1 therapies in this context remains unclear. Recent advances in cancer treatment include immune checkpoint inhibitors (ICIs) like nivolumab, which are used in various cancers. This study explores the impact of HBV on survival and treatment response in metastatic non-small cell lung cancer (NSCLC) patients receiving anti-PD-1/PD-L1 therapy. METHODS: We retrospectively analyzed metastatic NSCLC patients undergoing anti-PD-1/PD-L1 therapy, examining their characteristics, HBV serology, treatment response, and mortality.Patients were categorized into two groups based on HBV serology: Anti-HBc+ and Anti-HBc-.We compared their disease progression and mortality rates.Overall survival (OS) and progression-free survival (PFS) were assessed using Kaplan-Meier analysis, with p-values < 0.05 considered statistically significant. RESULTS: 241 patients were included in the study. All patients were diagnosed with metastatic NSCLC. 99 (41%) patients had disease progression and 107 (44%) patients had mortality (Table-1). When divided into two groups according to hepatitis B serology, 49 patients were Anti-HBc+ and 192 patients were AntiHbc-. When these two groups were compared according to their mortality, a statistically significant difference was found in the AntiHBc+ group (Table-2). When OS and PFS data were compared according to serology, the survival rate was statistically significantly higher in the AntiHbc+ group(Table-3). CONCLUSIONS: Our findings indicate that patients with Anti-HBc+ status may have higher PD-L1 expression compared to those without chronic HBV infection, potentially leading to better responses to anti-PD-1/PD-L1 therapy. |
| format | Article |
| id | doaj-art-9ee810b286334ea2a22e01c39f48bf86 |
| institution | OA Journals |
| issn | 2213-7165 |
| language | English |
| publishDate | 2024-12-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Journal of Global Antimicrobial Resistance |
| spelling | doaj-art-9ee810b286334ea2a22e01c39f48bf862025-08-20T01:57:48ZengElsevierJournal of Global Antimicrobial Resistance2213-71652024-12-0139767710.1016/j.jgar.2024.10.248Association of Hepatitis-B virus infection status with survival and treatment response in non-small cell lung cancer patients on anti‐pd‐1/pd-l1 therapyEda Alp0Goncagul Akdag Topal1DENİZ IŞIK2Nedim Turan3Başakşehir Çam and Sakura City Hospital, Istanbul, TurkeyKartal Dr. Lütfi Kirdar City Hospital, Health Science University, Istanbul, TurkeyKartal Dr. Lütfi Kirdar City Hospital, Health Science University, Istanbul, TurkeyKartal Dr. Lütfi Kirdar City Hospital, Health Science University, Istanbul, TurkeyAIM: HBV reactivation is a significant risk for cancer patients undergoing immunosuppressive or chemotherapy. However, since these patients are often excluded from immunotherapy trials, the safety of anti-PD-1 and anti-PD-L1 therapies in this context remains unclear. Recent advances in cancer treatment include immune checkpoint inhibitors (ICIs) like nivolumab, which are used in various cancers. This study explores the impact of HBV on survival and treatment response in metastatic non-small cell lung cancer (NSCLC) patients receiving anti-PD-1/PD-L1 therapy. METHODS: We retrospectively analyzed metastatic NSCLC patients undergoing anti-PD-1/PD-L1 therapy, examining their characteristics, HBV serology, treatment response, and mortality.Patients were categorized into two groups based on HBV serology: Anti-HBc+ and Anti-HBc-.We compared their disease progression and mortality rates.Overall survival (OS) and progression-free survival (PFS) were assessed using Kaplan-Meier analysis, with p-values < 0.05 considered statistically significant. RESULTS: 241 patients were included in the study. All patients were diagnosed with metastatic NSCLC. 99 (41%) patients had disease progression and 107 (44%) patients had mortality (Table-1). When divided into two groups according to hepatitis B serology, 49 patients were Anti-HBc+ and 192 patients were AntiHbc-. When these two groups were compared according to their mortality, a statistically significant difference was found in the AntiHBc+ group (Table-2). When OS and PFS data were compared according to serology, the survival rate was statistically significantly higher in the AntiHbc+ group(Table-3). CONCLUSIONS: Our findings indicate that patients with Anti-HBc+ status may have higher PD-L1 expression compared to those without chronic HBV infection, potentially leading to better responses to anti-PD-1/PD-L1 therapy.http://www.sciencedirect.com/science/article/pii/S2213716524004259HBV reactivation,Anti-HBc,Nivolumab,immune checkpoint inhibitors,Anti-PD-1/PD-L1 therapy |
| spellingShingle | Eda Alp Goncagul Akdag Topal DENİZ IŞIK Nedim Turan Association of Hepatitis-B virus infection status with survival and treatment response in non-small cell lung cancer patients on anti‐pd‐1/pd-l1 therapy Journal of Global Antimicrobial Resistance HBV reactivation,Anti-HBc,Nivolumab,immune checkpoint inhibitors,Anti-PD-1/PD-L1 therapy |
| title | Association of Hepatitis-B virus infection status with survival and treatment response in non-small cell lung cancer patients on anti‐pd‐1/pd-l1 therapy |
| title_full | Association of Hepatitis-B virus infection status with survival and treatment response in non-small cell lung cancer patients on anti‐pd‐1/pd-l1 therapy |
| title_fullStr | Association of Hepatitis-B virus infection status with survival and treatment response in non-small cell lung cancer patients on anti‐pd‐1/pd-l1 therapy |
| title_full_unstemmed | Association of Hepatitis-B virus infection status with survival and treatment response in non-small cell lung cancer patients on anti‐pd‐1/pd-l1 therapy |
| title_short | Association of Hepatitis-B virus infection status with survival and treatment response in non-small cell lung cancer patients on anti‐pd‐1/pd-l1 therapy |
| title_sort | association of hepatitis b virus infection status with survival and treatment response in non small cell lung cancer patients on anti pd 1 pd l1 therapy |
| topic | HBV reactivation,Anti-HBc,Nivolumab,immune checkpoint inhibitors,Anti-PD-1/PD-L1 therapy |
| url | http://www.sciencedirect.com/science/article/pii/S2213716524004259 |
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