Effect of the APOE Polymorphism and Age Trajectories of Physiological Variables on Mortality: Application of Genetic Stochastic Process Model of Aging
We evaluated effects of the APOE polymorphism (carriers versus noncarriers of the e4 allele) and age trajectories of total cholesterol (CH) and diastolic blood pressure (DBP) on mortality risk in the Framingham Heart Study (original cohort). We found that long-lived carriers and noncarriers have dif...
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| Format: | Article |
| Language: | English |
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Wiley
2012-01-01
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| Series: | Scientifica |
| Online Access: | http://dx.doi.org/10.6064/2012/568628 |
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| author | Konstantin G. Arbeev Svetlana V. Ukraintseva Alexander M. Kulminski Igor Akushevich Liubov S. Arbeeva Irina V. Culminskaya Deqing Wu Anatoliy I. Yashin |
| author_facet | Konstantin G. Arbeev Svetlana V. Ukraintseva Alexander M. Kulminski Igor Akushevich Liubov S. Arbeeva Irina V. Culminskaya Deqing Wu Anatoliy I. Yashin |
| author_sort | Konstantin G. Arbeev |
| collection | DOAJ |
| description | We evaluated effects of the APOE polymorphism (carriers versus noncarriers of the e4 allele) and age trajectories of total cholesterol (CH) and diastolic blood pressure (DBP) on mortality risk in the Framingham Heart Study (original cohort). We found that long-lived carriers and noncarriers have different average age trajectories and long-lived individuals have consistently higher levels and less steep declines at old ages compared to short-lived individuals. We applied the stochastic process model of aging aimed at joint analyses of genetic and nongenetic subsamples of longitudinal data and estimated different aging-related characteristics for carriers and noncarriers which otherwise cannot be evaluated from data. We found that such characteristics differ in carriers and noncarriers: (1) carriers have better adaptive capacity than noncarriers in case of CH, whereas for DBP the opposite situation is observed; (2) mean allostatic trajectories are higher in carriers and they differ from “optimal” trajectories minimizing mortality risk; (3) noncarriers have lower baseline mortality rates at younger ages but they increase faster than those for carriers resulting in intersection at the oldest ages. Such observations strongly indicate the presence of a genetic component in respective aging-related mechanisms. Such differences may contribute to patterns of allele- and sex-specific mortality rates. |
| format | Article |
| id | doaj-art-9ee2fa1f85a9420d8f91d5f580937ff0 |
| institution | OA Journals |
| issn | 2090-908X |
| language | English |
| publishDate | 2012-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Scientifica |
| spelling | doaj-art-9ee2fa1f85a9420d8f91d5f580937ff02025-08-20T02:18:32ZengWileyScientifica2090-908X2012-01-01201210.6064/2012/568628568628Effect of the APOE Polymorphism and Age Trajectories of Physiological Variables on Mortality: Application of Genetic Stochastic Process Model of AgingKonstantin G. Arbeev0Svetlana V. Ukraintseva1Alexander M. Kulminski2Igor Akushevich3Liubov S. Arbeeva4Irina V. Culminskaya5Deqing Wu6Anatoliy I. Yashin7Center for Population Health and Aging, Duke University, P.O. Box 90408, Durham, NC 27708-0408, USACenter for Population Health and Aging, Duke University, P.O. Box 90408, Durham, NC 27708-0408, USACenter for Population Health and Aging, Duke University, P.O. Box 90408, Durham, NC 27708-0408, USACenter for Population Health and Aging, Duke University, P.O. Box 90408, Durham, NC 27708-0408, USACenter for Population Health and Aging, Duke University, P.O. Box 90408, Durham, NC 27708-0408, USACenter for Population Health and Aging, Duke University, P.O. Box 90408, Durham, NC 27708-0408, USACenter for Population Health and Aging, Duke University, P.O. Box 90408, Durham, NC 27708-0408, USACenter for Population Health and Aging, Duke University, P.O. Box 90408, Durham, NC 27708-0408, USAWe evaluated effects of the APOE polymorphism (carriers versus noncarriers of the e4 allele) and age trajectories of total cholesterol (CH) and diastolic blood pressure (DBP) on mortality risk in the Framingham Heart Study (original cohort). We found that long-lived carriers and noncarriers have different average age trajectories and long-lived individuals have consistently higher levels and less steep declines at old ages compared to short-lived individuals. We applied the stochastic process model of aging aimed at joint analyses of genetic and nongenetic subsamples of longitudinal data and estimated different aging-related characteristics for carriers and noncarriers which otherwise cannot be evaluated from data. We found that such characteristics differ in carriers and noncarriers: (1) carriers have better adaptive capacity than noncarriers in case of CH, whereas for DBP the opposite situation is observed; (2) mean allostatic trajectories are higher in carriers and they differ from “optimal” trajectories minimizing mortality risk; (3) noncarriers have lower baseline mortality rates at younger ages but they increase faster than those for carriers resulting in intersection at the oldest ages. Such observations strongly indicate the presence of a genetic component in respective aging-related mechanisms. Such differences may contribute to patterns of allele- and sex-specific mortality rates.http://dx.doi.org/10.6064/2012/568628 |
| spellingShingle | Konstantin G. Arbeev Svetlana V. Ukraintseva Alexander M. Kulminski Igor Akushevich Liubov S. Arbeeva Irina V. Culminskaya Deqing Wu Anatoliy I. Yashin Effect of the APOE Polymorphism and Age Trajectories of Physiological Variables on Mortality: Application of Genetic Stochastic Process Model of Aging Scientifica |
| title | Effect of the APOE Polymorphism and Age Trajectories of Physiological Variables on Mortality: Application of Genetic Stochastic Process Model of Aging |
| title_full | Effect of the APOE Polymorphism and Age Trajectories of Physiological Variables on Mortality: Application of Genetic Stochastic Process Model of Aging |
| title_fullStr | Effect of the APOE Polymorphism and Age Trajectories of Physiological Variables on Mortality: Application of Genetic Stochastic Process Model of Aging |
| title_full_unstemmed | Effect of the APOE Polymorphism and Age Trajectories of Physiological Variables on Mortality: Application of Genetic Stochastic Process Model of Aging |
| title_short | Effect of the APOE Polymorphism and Age Trajectories of Physiological Variables on Mortality: Application of Genetic Stochastic Process Model of Aging |
| title_sort | effect of the apoe polymorphism and age trajectories of physiological variables on mortality application of genetic stochastic process model of aging |
| url | http://dx.doi.org/10.6064/2012/568628 |
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