Structural and iron content changes in subcortical vascular mild cognitive impairment: a combined voxel-based morphometry and quantitative susceptibility mapping study
Background: Further studies are necessary to investigate the neural mechanisms elemental of subcortical vascular mild cognitive impairment (svMCI), which is considered as precursor to vascular dementia (VaD). This objective of this research was to investigate the alterations in gray matter volume an...
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Elsevier
2025-01-01
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| Series: | Brain Research Bulletin |
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| Online Access: | http://www.sciencedirect.com/science/article/pii/S0361923024002946 |
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| author | Yushuang Liu Yingqi Lu Liyu Hu Jinping Xu Xingchen Liu Nan Yang Shangjie Chen Zhongling Zhang |
| author_facet | Yushuang Liu Yingqi Lu Liyu Hu Jinping Xu Xingchen Liu Nan Yang Shangjie Chen Zhongling Zhang |
| author_sort | Yushuang Liu |
| collection | DOAJ |
| description | Background: Further studies are necessary to investigate the neural mechanisms elemental of subcortical vascular mild cognitive impairment (svMCI), which is considered as precursor to vascular dementia (VaD). This objective of this research was to investigate the alterations in gray matter volume and brain iron deposition in patients with svMCI. Methods: This study involved 23 patients classified as health controls (HC) and 20 patients diagnosed with svMCI. All participants received cognitive assessments and magnetic resonance imaging (MRI). This research contains voxel-based morphometry (VBM), voxel-based quantitative susceptibility mapping (QSM) analysis, ROI-based QSM analysis, and correlation analysis. Results: svMCI patients showed more seriously cognitive impairment than HC patients. VBM analyses showed gray matter atrophy in the cingulate gyrus in the svMCI. Voxel-based QSM analyses showed increased susceptibilities in the right middle frontal gyrus, left paracentral lobule, as well as decreased susceptibility in the right postcentral gyrus in the svMCI. And ROI-based QSM analyses showed increased susceptibilities in left caudate nucleus and cerebellum in the svMCI. In addition, the susceptibility in left middle cingulate cortex and paracingulate gyrus was positively correlated associated with MoCA scores (r = 0.538 p < 0.001), and the susceptibility in the right middle frontal gyrus was negatively correlated with MoCA scores (r = -0.418 p < 0.007). Conclusions: The results of our studies suggest that morphological alterations and iron burden in the brain may be related to cognitive dysfunction in svMCI patients, providing a new way to explore underlying neural mechanisms of cognitive dysfunction. |
| format | Article |
| id | doaj-art-9edc941c9edf408294babf52ad4fc047 |
| institution | Kabale University |
| issn | 1873-2747 |
| language | English |
| publishDate | 2025-01-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Brain Research Bulletin |
| spelling | doaj-art-9edc941c9edf408294babf52ad4fc0472025-01-10T04:37:00ZengElsevierBrain Research Bulletin1873-27472025-01-01220111160Structural and iron content changes in subcortical vascular mild cognitive impairment: a combined voxel-based morphometry and quantitative susceptibility mapping studyYushuang Liu0Yingqi Lu1Liyu Hu2Jinping Xu3Xingchen Liu4Nan Yang5Shangjie Chen6Zhongling Zhang7Department of Neurology, The First Affiliated Hospital of Harbin Medical University, Harbin 150001, China; Guangzhou Geriatric Hospital, Guangzhou 510000, ChinaDepartment of Rehabilitation Medicine, The People’s Hospital of Baoan Shenzhen, Shenzhen 518101, China; The Second Affiliated Hospital of Shenzhen University, Shenzhen 518101, China; Institute of Biomedical and Health Engineering, Shenzhen Institutes of Advanced Technology, Chinese Academy of Sciences, Shenzhen 518055, ChinaInstitute of Biomedical and Health Engineering, Shenzhen Institutes of Advanced Technology, Chinese Academy of Sciences, Shenzhen 518055, ChinaInstitute of Biomedical and Health Engineering, Shenzhen Institutes of Advanced Technology, Chinese Academy of Sciences, Shenzhen 518055, ChinaHospital of Traditional Chinese Medicine of Zhongshan, Zhongshan 528400, ChinaHospital of Traditional Chinese Medicine of Zhongshan, Zhongshan 528400, China; Correspondence to: Department of Neurology, The First Affiliated Hospital of Harbin Medical University, Harbin 150001, China.Department of Rehabilitation Medicine, The People’s Hospital of Baoan Shenzhen, Shenzhen 518101, China; The Second Affiliated Hospital of Shenzhen University, Shenzhen 518101, China; Corresponding author.Department of Neurology, The First Affiliated Hospital of Harbin Medical University, Harbin 150001, China; Correspondence to: Department of Neurology, The First Affiliated Hospital of Harbin Medical University, Harbin 150001, China.Background: Further studies are necessary to investigate the neural mechanisms elemental of subcortical vascular mild cognitive impairment (svMCI), which is considered as precursor to vascular dementia (VaD). This objective of this research was to investigate the alterations in gray matter volume and brain iron deposition in patients with svMCI. Methods: This study involved 23 patients classified as health controls (HC) and 20 patients diagnosed with svMCI. All participants received cognitive assessments and magnetic resonance imaging (MRI). This research contains voxel-based morphometry (VBM), voxel-based quantitative susceptibility mapping (QSM) analysis, ROI-based QSM analysis, and correlation analysis. Results: svMCI patients showed more seriously cognitive impairment than HC patients. VBM analyses showed gray matter atrophy in the cingulate gyrus in the svMCI. Voxel-based QSM analyses showed increased susceptibilities in the right middle frontal gyrus, left paracentral lobule, as well as decreased susceptibility in the right postcentral gyrus in the svMCI. And ROI-based QSM analyses showed increased susceptibilities in left caudate nucleus and cerebellum in the svMCI. In addition, the susceptibility in left middle cingulate cortex and paracingulate gyrus was positively correlated associated with MoCA scores (r = 0.538 p < 0.001), and the susceptibility in the right middle frontal gyrus was negatively correlated with MoCA scores (r = -0.418 p < 0.007). Conclusions: The results of our studies suggest that morphological alterations and iron burden in the brain may be related to cognitive dysfunction in svMCI patients, providing a new way to explore underlying neural mechanisms of cognitive dysfunction.http://www.sciencedirect.com/science/article/pii/S0361923024002946Subcortical vascular mild cognitive impairment (svMCI)Magnetic resonance imaging (MRI)Voxel-based morphometry (VBM)Quantitative susceptibility mapping (QSM)Cognitive impairment |
| spellingShingle | Yushuang Liu Yingqi Lu Liyu Hu Jinping Xu Xingchen Liu Nan Yang Shangjie Chen Zhongling Zhang Structural and iron content changes in subcortical vascular mild cognitive impairment: a combined voxel-based morphometry and quantitative susceptibility mapping study Brain Research Bulletin Subcortical vascular mild cognitive impairment (svMCI) Magnetic resonance imaging (MRI) Voxel-based morphometry (VBM) Quantitative susceptibility mapping (QSM) Cognitive impairment |
| title | Structural and iron content changes in subcortical vascular mild cognitive impairment: a combined voxel-based morphometry and quantitative susceptibility mapping study |
| title_full | Structural and iron content changes in subcortical vascular mild cognitive impairment: a combined voxel-based morphometry and quantitative susceptibility mapping study |
| title_fullStr | Structural and iron content changes in subcortical vascular mild cognitive impairment: a combined voxel-based morphometry and quantitative susceptibility mapping study |
| title_full_unstemmed | Structural and iron content changes in subcortical vascular mild cognitive impairment: a combined voxel-based morphometry and quantitative susceptibility mapping study |
| title_short | Structural and iron content changes in subcortical vascular mild cognitive impairment: a combined voxel-based morphometry and quantitative susceptibility mapping study |
| title_sort | structural and iron content changes in subcortical vascular mild cognitive impairment a combined voxel based morphometry and quantitative susceptibility mapping study |
| topic | Subcortical vascular mild cognitive impairment (svMCI) Magnetic resonance imaging (MRI) Voxel-based morphometry (VBM) Quantitative susceptibility mapping (QSM) Cognitive impairment |
| url | http://www.sciencedirect.com/science/article/pii/S0361923024002946 |
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