Multifaceted functions of the Wilms tumor 1 protein: From its expression in various malignancies to targeted therapy
Wilms tumor 1 (WT1) is a multifaceted protein with dual functions, acting both as a tumor suppressor and as a transcriptional activator of oncogenes. WT1 is highly expressed in various types of solid tumors and leukemia, and its elevated expression is associated with a poor prognosis for patients. H...
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| Format: | Article |
| Language: | English |
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Elsevier
2025-02-01
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| Series: | Translational Oncology |
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| Online Access: | http://www.sciencedirect.com/science/article/pii/S1936523324003632 |
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| author | Qing Nian Yan Lin Jinhao Zeng Yanna Zhang Rongxing Liu |
| author_facet | Qing Nian Yan Lin Jinhao Zeng Yanna Zhang Rongxing Liu |
| author_sort | Qing Nian |
| collection | DOAJ |
| description | Wilms tumor 1 (WT1) is a multifaceted protein with dual functions, acting both as a tumor suppressor and as a transcriptional activator of oncogenes. WT1 is highly expressed in various types of solid tumors and leukemia, and its elevated expression is associated with a poor prognosis for patients. High WT1 expression also indicates a greater risk of refractory disease or relapse. Consequently, targeting WT1 is an effective strategy for disease prevention and relapse mitigation. Substantial information is available on the pathogenesis of WT1 in various diseases, and several WT1-targeted therapies, including chemical drugs, natural products, and targeted vaccines, are available. We provide a comprehensive review of the mechanisms by which WT1 influences malignancies and summarize the resulting therapeutic approaches thoroughly. This article provides information on the roles of WT1 in the pathogenesis of different cancers and provides insights into drugs and immunotherapies targeting WT1. The goal of this work is to provide a systematic understanding of the current research landscape and of future directions for WT1-related studies. |
| format | Article |
| id | doaj-art-9ed643a93b1f473dbaa2eb4f0ab43c33 |
| institution | Kabale University |
| issn | 1936-5233 |
| language | English |
| publishDate | 2025-02-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Translational Oncology |
| spelling | doaj-art-9ed643a93b1f473dbaa2eb4f0ab43c332025-01-22T05:41:25ZengElsevierTranslational Oncology1936-52332025-02-0152102237Multifaceted functions of the Wilms tumor 1 protein: From its expression in various malignancies to targeted therapyQing Nian0Yan Lin1Jinhao Zeng2Yanna Zhang3Rongxing Liu4Department of Transfusion, Sichuan Provincial People's Hospital, University of Electronic Science and Technology of China, 32W. Sec. 2, 1st Ring Rd., Qingyang District, Chengdu, Sichuan, China, 610072; Corresponding author at: Department of Transfusion, Sichuan Provincial People's Hospital, University of Electronic Science and Technology of China, 32W. Sec. 2, 1st Ring Rd., Qingyang District, Chengdu, Sichuan, China.Department of Gastroenterology, Hospital of Chengdu University of Traditional Chinese Medicine, 39 Shierqiaolu, Chengdu, Sichuan, China, 610072Department of Gastroenterology, Hospital of Chengdu University of Traditional Chinese Medicine, 39 Shierqiaolu, Chengdu, Sichuan, China, 610072Department of Transfusion, Sichuan Provincial People's Hospital, University of Electronic Science and Technology of China, 32W. Sec. 2, 1st Ring Rd., Qingyang District, Chengdu, Sichuan, China, 610072Department of Pharmacy, The Second Affiliated Hospital, Army Medical University, 183 Xinqiao Road, Chongqing, China, 400000; Corresponding author at: Department of Pharmacy, The Second Affiliated Hospital, Army Medical University, 183 Xinqiao Road, Chongqing, China, Postal code: 400000.Wilms tumor 1 (WT1) is a multifaceted protein with dual functions, acting both as a tumor suppressor and as a transcriptional activator of oncogenes. WT1 is highly expressed in various types of solid tumors and leukemia, and its elevated expression is associated with a poor prognosis for patients. High WT1 expression also indicates a greater risk of refractory disease or relapse. Consequently, targeting WT1 is an effective strategy for disease prevention and relapse mitigation. Substantial information is available on the pathogenesis of WT1 in various diseases, and several WT1-targeted therapies, including chemical drugs, natural products, and targeted vaccines, are available. We provide a comprehensive review of the mechanisms by which WT1 influences malignancies and summarize the resulting therapeutic approaches thoroughly. This article provides information on the roles of WT1 in the pathogenesis of different cancers and provides insights into drugs and immunotherapies targeting WT1. The goal of this work is to provide a systematic understanding of the current research landscape and of future directions for WT1-related studies.http://www.sciencedirect.com/science/article/pii/S1936523324003632WT1Malignant diseaseTargeted therapiesVaccinesNatural products |
| spellingShingle | Qing Nian Yan Lin Jinhao Zeng Yanna Zhang Rongxing Liu Multifaceted functions of the Wilms tumor 1 protein: From its expression in various malignancies to targeted therapy Translational Oncology WT1 Malignant disease Targeted therapies Vaccines Natural products |
| title | Multifaceted functions of the Wilms tumor 1 protein: From its expression in various malignancies to targeted therapy |
| title_full | Multifaceted functions of the Wilms tumor 1 protein: From its expression in various malignancies to targeted therapy |
| title_fullStr | Multifaceted functions of the Wilms tumor 1 protein: From its expression in various malignancies to targeted therapy |
| title_full_unstemmed | Multifaceted functions of the Wilms tumor 1 protein: From its expression in various malignancies to targeted therapy |
| title_short | Multifaceted functions of the Wilms tumor 1 protein: From its expression in various malignancies to targeted therapy |
| title_sort | multifaceted functions of the wilms tumor 1 protein from its expression in various malignancies to targeted therapy |
| topic | WT1 Malignant disease Targeted therapies Vaccines Natural products |
| url | http://www.sciencedirect.com/science/article/pii/S1936523324003632 |
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