A new risk factor? Diagonal earlobe crease (Frank's sign) associated with intracranial aneurysms: a case–control study

Objective: To evaluate the association of diagonal earlobe crease (DELC, Frank's sign), laterality, and type of DELC with the presence of intracranial arterial aneurysms (IAA). Methods: The authors conducted a hospital-based case–control study involving 130 patients diagnosed with IAA and 130 a...

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Bibliographic Details
Main Authors:	Victor Ramzes Chavez-Herrera, Bayron A. Sandoval-Bonilla, Joel Abraham Velazquez-Castillo, Pedro Adrian Gonzalez-Zavala, Flavio Hernandez-Gonzalez, Felix Adrian Vergara-Martinez, Anabel Saldaña-Gonzalez, Miguel Abdo-Toro, Blas Ezequiel Lopez-Felix, Ivan Tellez-Medina, Martin Paredes-Cruz, Rabindranath Garcia-Lopez
Format:	Article
Language:	English
Published:	Elsevier 2025-07-01
Series:	World Neurosurgery: X
Subjects:	Diagonal earlobe crease Cerebrovascular disease Frank's sign Intracranial aneurysms
Online Access:	http://www.sciencedirect.com/science/article/pii/S2590139725000432
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A new risk factor? Diagonal earlobe crease (Frank's sign) associated with intracranial aneurysms: a case–control study

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