Definition and risk factors for early recurrence in patients with laryngeal cancer after initial surgery
Abstract To determine an optimal cut-off value for distinguishing early and late recurrence in patients with laryngeal cancer after initial surgery and to evaluate the risk factors for early recurrence. This retrospective study included 328 patients with laryngeal cancer who underwent initial resect...
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| Language: | English |
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Nature Portfolio
2025-04-01
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| Series: | Scientific Reports |
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| Online Access: | https://doi.org/10.1038/s41598-025-89223-6 |
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| author | Qin Lin Longxiang Zheng Xiaoqiang Chen Desheng Wang |
| author_facet | Qin Lin Longxiang Zheng Xiaoqiang Chen Desheng Wang |
| author_sort | Qin Lin |
| collection | DOAJ |
| description | Abstract To determine an optimal cut-off value for distinguishing early and late recurrence in patients with laryngeal cancer after initial surgery and to evaluate the risk factors for early recurrence. This retrospective study included 328 patients with laryngeal cancer who underwent initial resection in our hospital from January 2014 to April 2018. A minimum P-value approach was used to determine the optimal cut-off value to divide patients into early and late recurrence groups. The clinicopathological characteristics were compared between the two groups. The risk factors for early recurrence were evaluated using logistic regression analysis. The optimal cut-off value to identify between early recurrence (n = 51, 50.5%) and late recurrence (n = 50, 49.5%) was 17 months (p < 1e−17). The overall survival of the late recurrence group (48.36 ± 16.02 months) was longer than the early recurrence group (32.61 ± 19.65 months) significantly (p < 0.001). Lymphovascular invasion (p = 0.038), patients without adjuvant radiotherapy (p = 0.043), advanced tumor, node, metastasis (TNM) stage (p = 0.035), and positive surgical margins (p = 0.045) were independent risk factors for early recurrence. The best cut-off value to identify early recurrence after initial surgery for laryngeal cancer was 17 months. Intensive follow-up and adjuvant radiotherapy may be beneficial for patients with risk factors for early recurrence. |
| format | Article |
| id | doaj-art-9ed17a9322c14675be13a45c95f29dbc |
| institution | OA Journals |
| issn | 2045-2322 |
| language | English |
| publishDate | 2025-04-01 |
| publisher | Nature Portfolio |
| record_format | Article |
| series | Scientific Reports |
| spelling | doaj-art-9ed17a9322c14675be13a45c95f29dbc2025-08-20T02:17:57ZengNature PortfolioScientific Reports2045-23222025-04-0115111010.1038/s41598-025-89223-6Definition and risk factors for early recurrence in patients with laryngeal cancer after initial surgeryQin Lin0Longxiang Zheng1Xiaoqiang Chen2Desheng Wang3Department of Otolaryngology, Fujian Medical University Union HospitalDepartment of Otolaryngology, Fujian Medical University Union HospitalDepartment of Otolaryngology, Fujian Medical University Union HospitalDepartment of Otolaryngology, Fujian Medical University Union HospitalAbstract To determine an optimal cut-off value for distinguishing early and late recurrence in patients with laryngeal cancer after initial surgery and to evaluate the risk factors for early recurrence. This retrospective study included 328 patients with laryngeal cancer who underwent initial resection in our hospital from January 2014 to April 2018. A minimum P-value approach was used to determine the optimal cut-off value to divide patients into early and late recurrence groups. The clinicopathological characteristics were compared between the two groups. The risk factors for early recurrence were evaluated using logistic regression analysis. The optimal cut-off value to identify between early recurrence (n = 51, 50.5%) and late recurrence (n = 50, 49.5%) was 17 months (p < 1e−17). The overall survival of the late recurrence group (48.36 ± 16.02 months) was longer than the early recurrence group (32.61 ± 19.65 months) significantly (p < 0.001). Lymphovascular invasion (p = 0.038), patients without adjuvant radiotherapy (p = 0.043), advanced tumor, node, metastasis (TNM) stage (p = 0.035), and positive surgical margins (p = 0.045) were independent risk factors for early recurrence. The best cut-off value to identify early recurrence after initial surgery for laryngeal cancer was 17 months. Intensive follow-up and adjuvant radiotherapy may be beneficial for patients with risk factors for early recurrence.https://doi.org/10.1038/s41598-025-89223-6Laryngeal cancerPostoperative recurrenceEarly recurrenceLate recurrenceRisk factors |
| spellingShingle | Qin Lin Longxiang Zheng Xiaoqiang Chen Desheng Wang Definition and risk factors for early recurrence in patients with laryngeal cancer after initial surgery Scientific Reports Laryngeal cancer Postoperative recurrence Early recurrence Late recurrence Risk factors |
| title | Definition and risk factors for early recurrence in patients with laryngeal cancer after initial surgery |
| title_full | Definition and risk factors for early recurrence in patients with laryngeal cancer after initial surgery |
| title_fullStr | Definition and risk factors for early recurrence in patients with laryngeal cancer after initial surgery |
| title_full_unstemmed | Definition and risk factors for early recurrence in patients with laryngeal cancer after initial surgery |
| title_short | Definition and risk factors for early recurrence in patients with laryngeal cancer after initial surgery |
| title_sort | definition and risk factors for early recurrence in patients with laryngeal cancer after initial surgery |
| topic | Laryngeal cancer Postoperative recurrence Early recurrence Late recurrence Risk factors |
| url | https://doi.org/10.1038/s41598-025-89223-6 |
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