Associations between Children’s Exposure to PM2.5 and their Serum Inflammatory Responses in Taiwan
Abstract PM2.5-induced inflammation have been demonstrated in the cellular and animal models, but few studies reported the associations of schoolchildren exposure to PM2.5 with their serum inflammatory biomarkers. Our goal was to examine whether serum inflammation was activated after children with l...
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| Format: | Article |
| Language: | English |
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Springer
2022-11-01
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| Series: | Aerosol and Air Quality Research |
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| Online Access: | https://doi.org/10.4209/aaqr.220288 |
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| author | Wei-Jung Tseng Jian-He Lu How-Ran Chao Ming-Hsien Tsai Yu-Ting Chang Liang-Jen Wang Chih-Cheng Chen Wan-Nurdiyana-Wan Mansor Juliana Jalaludin Chih-Lung Wang Ying-I Tsai |
| author_facet | Wei-Jung Tseng Jian-He Lu How-Ran Chao Ming-Hsien Tsai Yu-Ting Chang Liang-Jen Wang Chih-Cheng Chen Wan-Nurdiyana-Wan Mansor Juliana Jalaludin Chih-Lung Wang Ying-I Tsai |
| author_sort | Wei-Jung Tseng |
| collection | DOAJ |
| description | Abstract PM2.5-induced inflammation have been demonstrated in the cellular and animal models, but few studies reported the associations of schoolchildren exposure to PM2.5 with their serum inflammatory biomarkers. Our goal was to examine whether serum inflammation was activated after children with long-term exposure to PM2.5 in an industrialized city of Taiwan. Schoolchildren (n = 183) between the ages of 6 and 12 years living in southern Taiwan were recruited to measure their serum inflammation including interferon-γ (IFN-γ), IFN-α2, interleukin 1b (IL-1b), IL-2, IL-6, IL-10, IL-13, IL-17, monocyte chemotactic protein (MCP)-l, and tumor necrosis factor (TNF-α). The subjects were sorted into three groups based on residential addresses in loW-PM2.5, high-PM2.5, and traffic-related-air-pollution (TRAP)-PM2.5 areas on the basis of long-term PM2.5 pollution data from air monitoring sites collected over the past decade. Children living in the TRAP-PM2.5 areas had significantly higher TNF-α serum levels than those living in the I0W-PM2.5 areas. Although serum levels of MCP-1 in children exposed to low PM2.5 concentrations were lower than those in children exposure to high and TRAP PM2.5 levels, the differences were nonsignificant. Principal component (PC) analyses revealed a close association between serum MCP-1 and outdoor PM2.5 (Rotated PC2 (RPC2) and percentage of variance = 10.5%), whereas serum IFN-γ, IFN-α2, IL-1b, IL-2, IL-6, IL-10, IL-13, IL-17, and TNF-α were highly correlated (RPC1 and percentage of variance = 45.5%). Children’s serum TNF-α was significantly linked to PM2.5 exposure scenarios (p = 0.031) by the test of the multivariate analysis (adjusted R2 = 0.033, p = 0.039), but the other variables of age (p = 0.147) and gender (p = 0.291) were not statistically significant. In conclusion, serum TNF-α might be positively and significantly correlated with the longitudinal exposure of schoolchildren to PM2.5, especially among children living in TRAP-PM2.5 region. |
| format | Article |
| id | doaj-art-9ece3199bd7341f5bab0bb4b51ff802d |
| institution | Kabale University |
| issn | 1680-8584 2071-1409 |
| language | English |
| publishDate | 2022-11-01 |
| publisher | Springer |
| record_format | Article |
| series | Aerosol and Air Quality Research |
| spelling | doaj-art-9ece3199bd7341f5bab0bb4b51ff802d2025-02-09T12:18:17ZengSpringerAerosol and Air Quality Research1680-85842071-14092022-11-01221211510.4209/aaqr.220288Associations between Children’s Exposure to PM2.5 and their Serum Inflammatory Responses in TaiwanWei-Jung Tseng0Jian-He Lu1How-Ran Chao2Ming-Hsien Tsai3Yu-Ting Chang4Liang-Jen Wang5Chih-Cheng Chen6Wan-Nurdiyana-Wan Mansor7Juliana Jalaludin8Chih-Lung Wang9Ying-I Tsai10Department of Environmental Science and Engineering, College of Engineering, National Pingtung University of Science and TechnologyEmerging Compounds Research Center, General Research Service Center, National Pingtung University of Science and TechnologyDepartment of Environmental Science and Engineering, College of Engineering, National Pingtung University of Science and TechnologyEmerging Compounds Research Center, General Research Service Center, National Pingtung University of Science and TechnologyDepartment of Environmental Science and Engineering, College of Engineering, National Pingtung University of Science and TechnologyDepartment of Child and Adolescent Psychiatry, Kaohsiung Chang Gung Memorial Hospital and Chang Gung University College of MedicineDepartment of Pediatrics, Kaohsiung Chang Gung Memorial Hospital and Chang Gung University College of MedicineFaculty of Ocean Engineering Technology & Informatics, Universiti Malaysia TerengganuFaculty of Medicine and Health Science, Universiti Putra MalaysiaDepartment of Civil Engineering and Geomatics, Cheng Shiu UniversityDepartment of Environmental Engineering and Science, Chia Nan University of Pharmacy & ScienceAbstract PM2.5-induced inflammation have been demonstrated in the cellular and animal models, but few studies reported the associations of schoolchildren exposure to PM2.5 with their serum inflammatory biomarkers. Our goal was to examine whether serum inflammation was activated after children with long-term exposure to PM2.5 in an industrialized city of Taiwan. Schoolchildren (n = 183) between the ages of 6 and 12 years living in southern Taiwan were recruited to measure their serum inflammation including interferon-γ (IFN-γ), IFN-α2, interleukin 1b (IL-1b), IL-2, IL-6, IL-10, IL-13, IL-17, monocyte chemotactic protein (MCP)-l, and tumor necrosis factor (TNF-α). The subjects were sorted into three groups based on residential addresses in loW-PM2.5, high-PM2.5, and traffic-related-air-pollution (TRAP)-PM2.5 areas on the basis of long-term PM2.5 pollution data from air monitoring sites collected over the past decade. Children living in the TRAP-PM2.5 areas had significantly higher TNF-α serum levels than those living in the I0W-PM2.5 areas. Although serum levels of MCP-1 in children exposed to low PM2.5 concentrations were lower than those in children exposure to high and TRAP PM2.5 levels, the differences were nonsignificant. Principal component (PC) analyses revealed a close association between serum MCP-1 and outdoor PM2.5 (Rotated PC2 (RPC2) and percentage of variance = 10.5%), whereas serum IFN-γ, IFN-α2, IL-1b, IL-2, IL-6, IL-10, IL-13, IL-17, and TNF-α were highly correlated (RPC1 and percentage of variance = 45.5%). Children’s serum TNF-α was significantly linked to PM2.5 exposure scenarios (p = 0.031) by the test of the multivariate analysis (adjusted R2 = 0.033, p = 0.039), but the other variables of age (p = 0.147) and gender (p = 0.291) were not statistically significant. In conclusion, serum TNF-α might be positively and significantly correlated with the longitudinal exposure of schoolchildren to PM2.5, especially among children living in TRAP-PM2.5 region.https://doi.org/10.4209/aaqr.220288PM2.5Tumor necrosis factor (TNF-α)Inflammatory responsesTraffic-related air pollution (TRAP)Health risk |
| spellingShingle | Wei-Jung Tseng Jian-He Lu How-Ran Chao Ming-Hsien Tsai Yu-Ting Chang Liang-Jen Wang Chih-Cheng Chen Wan-Nurdiyana-Wan Mansor Juliana Jalaludin Chih-Lung Wang Ying-I Tsai Associations between Children’s Exposure to PM2.5 and their Serum Inflammatory Responses in Taiwan Aerosol and Air Quality Research PM2.5 Tumor necrosis factor (TNF-α) Inflammatory responses Traffic-related air pollution (TRAP) Health risk |
| title | Associations between Children’s Exposure to PM2.5 and their Serum Inflammatory Responses in Taiwan |
| title_full | Associations between Children’s Exposure to PM2.5 and their Serum Inflammatory Responses in Taiwan |
| title_fullStr | Associations between Children’s Exposure to PM2.5 and their Serum Inflammatory Responses in Taiwan |
| title_full_unstemmed | Associations between Children’s Exposure to PM2.5 and their Serum Inflammatory Responses in Taiwan |
| title_short | Associations between Children’s Exposure to PM2.5 and their Serum Inflammatory Responses in Taiwan |
| title_sort | associations between children s exposure to pm2 5 and their serum inflammatory responses in taiwan |
| topic | PM2.5 Tumor necrosis factor (TNF-α) Inflammatory responses Traffic-related air pollution (TRAP) Health risk |
| url | https://doi.org/10.4209/aaqr.220288 |
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