Cognitive benefits of folic acid supplementation during pregnancy track with epigenetic changes at an imprint regulator

Cognitive benefits of folic acid supplementation during pregnancy track with epigenetic changes at an imprint regulator

Abstract Background The human ZFP57 gene is a major regulator of imprinted genes, maintaining DNA methylation marks that distinguish parent-of-origin-specific alleles. DNA methylation of the gene itself has shown sensitivity to environmental stimuli, particularly folate status. However, the role of...

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Bibliographic Details
Main Authors:	L. Hilman, M. Ondičová, A. Caffrey, M. Clements, C. Conway, M. Ward, K. Pentieva, R. E. Irwin, H. McNulty, C. P. Walsh
Format:	Article
Language:	English
Published:	BMC 2024-12-01
Series:	BMC Medicine
Subjects:	DNA methylation ZFP57 Methylation quantitative trait loci Linkage disequilibrium Folic acid
Online Access:	https://doi.org/10.1186/s12916-024-03804-2
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