Trypanosoma cruzi and its components as exogenous mediators of inflammation recognized through Toll-like receptors
TRYPANOSOMA cruzi is the etiologic agent of Chagas' disease, a parasitic disease of enormous importance in Latin America. Herein we review the studies that revealed the receptors from innate immunity that are involved in the recognition of this protozoan parasite. We showed that the recognition...
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| Format: | Article |
| Language: | English |
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Wiley
2004-01-01
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| Series: | Mediators of Inflammation |
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| Online Access: | http://dx.doi.org/10.1080/09511920410001713565 |
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| author | Marco A. Campos Ricardo T. Gazzinelli |
| author_facet | Marco A. Campos Ricardo T. Gazzinelli |
| author_sort | Marco A. Campos |
| collection | DOAJ |
| description | TRYPANOSOMA cruzi is the etiologic agent of Chagas' disease, a parasitic disease of enormous importance in Latin America. Herein we review the studies that revealed the receptors from innate immunity that are involved in the recognition of this protozoan parasite. We showed that the recognition of T. cruzi and its components occurs through Toll-like receptors (TLR) 2/CD14. Further, we showed in vivo the importance of the myeloid differentiation factor (MyD88), an adapter protein essential for the function of TLRs, in determining the parasitemia and mortality rate of mice infected with T. cruzi. We also discuss the implications of these findings in the pathophysiology of Chagas' disease. |
| format | Article |
| id | doaj-art-9ecaaf90d2f34e698a393305753a538c |
| institution | OA Journals |
| issn | 0962-9351 1466-1861 |
| language | English |
| publishDate | 2004-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Mediators of Inflammation |
| spelling | doaj-art-9ecaaf90d2f34e698a393305753a538c2025-08-20T02:18:33ZengWileyMediators of Inflammation0962-93511466-18612004-01-0113313914310.1080/09511920410001713565Trypanosoma cruzi and its components as exogenous mediators of inflammation recognized through Toll-like receptorsMarco A. Campos0Ricardo T. Gazzinelli1Laboratory of Immunopathology, Centro de Pesquisas René Rachou, FIOCRUZ, Av. Augusto de Lima 1715, Barro Preto, Belo Horizonte, MG 30190-002, BrazilLaboratory of Immunopathology, Centro de Pesquisas René Rachou, FIOCRUZ, Av. Augusto de Lima 1715, Barro Preto, Belo Horizonte, MG 30190-002, BrazilTRYPANOSOMA cruzi is the etiologic agent of Chagas' disease, a parasitic disease of enormous importance in Latin America. Herein we review the studies that revealed the receptors from innate immunity that are involved in the recognition of this protozoan parasite. We showed that the recognition of T. cruzi and its components occurs through Toll-like receptors (TLR) 2/CD14. Further, we showed in vivo the importance of the myeloid differentiation factor (MyD88), an adapter protein essential for the function of TLRs, in determining the parasitemia and mortality rate of mice infected with T. cruzi. We also discuss the implications of these findings in the pathophysiology of Chagas' disease.http://dx.doi.org/10.1080/09511920410001713565Tryapnosoma cruzi Toll-like receptorshost defenseinnate immune responseinflammationglycosylphosphatidylinositol. |
| spellingShingle | Marco A. Campos Ricardo T. Gazzinelli Trypanosoma cruzi and its components as exogenous mediators of inflammation recognized through Toll-like receptors Mediators of Inflammation Tryapnosoma cruzi Toll-like receptors host defense innate immune response inflammation glycosylphosphatidylinositol. |
| title | Trypanosoma cruzi and its components as exogenous mediators of inflammation recognized through Toll-like receptors |
| title_full | Trypanosoma cruzi and its components as exogenous mediators of inflammation recognized through Toll-like receptors |
| title_fullStr | Trypanosoma cruzi and its components as exogenous mediators of inflammation recognized through Toll-like receptors |
| title_full_unstemmed | Trypanosoma cruzi and its components as exogenous mediators of inflammation recognized through Toll-like receptors |
| title_short | Trypanosoma cruzi and its components as exogenous mediators of inflammation recognized through Toll-like receptors |
| title_sort | trypanosoma cruzi and its components as exogenous mediators of inflammation recognized through toll like receptors |
| topic | Tryapnosoma cruzi Toll-like receptors host defense innate immune response inflammation glycosylphosphatidylinositol. |
| url | http://dx.doi.org/10.1080/09511920410001713565 |
| work_keys_str_mv | AT marcoacampos trypanosomacruzianditscomponentsasexogenousmediatorsofinflammationrecognizedthroughtolllikereceptors AT ricardotgazzinelli trypanosomacruzianditscomponentsasexogenousmediatorsofinflammationrecognizedthroughtolllikereceptors |