Interstitial fluid-based optical biosensors

The high reproducibility and reliability of optical biosensors, alongside the extraordinarily features of interstitial fluid (ISF) as a promising biological fluid with blood-like composition and yet noninvasive or minimally invasive sampling, have led to the development of a variety of the ISF-based...

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Main Authors: Atefeh Rahimzadeh, Abrisham Arjomandkhah, Mohammad Ali Kiani, Hamed Golmohammadi
Format: Article
Language:English
Published: Elsevier 2025-06-01
Series:Journal of Pharmaceutical and Biomedical Analysis Open
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Online Access:http://www.sciencedirect.com/science/article/pii/S2949771X25000258
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author Atefeh Rahimzadeh
Abrisham Arjomandkhah
Mohammad Ali Kiani
Hamed Golmohammadi
author_facet Atefeh Rahimzadeh
Abrisham Arjomandkhah
Mohammad Ali Kiani
Hamed Golmohammadi
author_sort Atefeh Rahimzadeh
collection DOAJ
description The high reproducibility and reliability of optical biosensors, alongside the extraordinarily features of interstitial fluid (ISF) as a promising biological fluid with blood-like composition and yet noninvasive or minimally invasive sampling, have led to the development of a variety of the ISF-based optical biosensors for diagnostic and health monitoring applications. In the present review, while introducing ISF, its characteristics, and the methods developed for its sampling, various types of optical biosensors developed so far for the colorimetric, fluorometric, and surface-enhanced Raman spectroscopy determination of (bio)chemical compounds in ISF are reviewed. Lastly, future prospects and views on the main challenges facing the further development of ISF-based optical biosensors are delineated. Building upon the extraordinary features of ISF-based optical biosensors as highly promising and potential biosensors, we anticipate that they will be greatly welcomed and many of the existing blood-based optical biosensors will be replaced by ISF-based ones in the near future.
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institution OA Journals
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publishDate 2025-06-01
publisher Elsevier
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series Journal of Pharmaceutical and Biomedical Analysis Open
spelling doaj-art-9ec28136e1164094b9763ff5e3f8d2f92025-08-20T01:49:23ZengElsevierJournal of Pharmaceutical and Biomedical Analysis Open2949-771X2025-06-01510007410.1016/j.jpbao.2025.100074Interstitial fluid-based optical biosensorsAtefeh Rahimzadeh0Abrisham Arjomandkhah1Mohammad Ali Kiani2Hamed Golmohammadi3Nanosensors Bioplatforms Laboratory, Chemistry and Chemical Engineering Research Center of Iran, Tehran 14335-186, IranNanosensors Bioplatforms Laboratory, Chemistry and Chemical Engineering Research Center of Iran, Tehran 14335-186, IranNanosensors Bioplatforms Laboratory, Chemistry and Chemical Engineering Research Center of Iran, Tehran 14335-186, IranCorresponding author.; Nanosensors Bioplatforms Laboratory, Chemistry and Chemical Engineering Research Center of Iran, Tehran 14335-186, IranThe high reproducibility and reliability of optical biosensors, alongside the extraordinarily features of interstitial fluid (ISF) as a promising biological fluid with blood-like composition and yet noninvasive or minimally invasive sampling, have led to the development of a variety of the ISF-based optical biosensors for diagnostic and health monitoring applications. In the present review, while introducing ISF, its characteristics, and the methods developed for its sampling, various types of optical biosensors developed so far for the colorimetric, fluorometric, and surface-enhanced Raman spectroscopy determination of (bio)chemical compounds in ISF are reviewed. Lastly, future prospects and views on the main challenges facing the further development of ISF-based optical biosensors are delineated. Building upon the extraordinary features of ISF-based optical biosensors as highly promising and potential biosensors, we anticipate that they will be greatly welcomed and many of the existing blood-based optical biosensors will be replaced by ISF-based ones in the near future.http://www.sciencedirect.com/science/article/pii/S2949771X25000258Skin interstitial fluidMicroneedleColorimetricFluorometricDiagnosticsHealth monitoring
spellingShingle Atefeh Rahimzadeh
Abrisham Arjomandkhah
Mohammad Ali Kiani
Hamed Golmohammadi
Interstitial fluid-based optical biosensors
Journal of Pharmaceutical and Biomedical Analysis Open
Skin interstitial fluid
Microneedle
Colorimetric
Fluorometric
Diagnostics
Health monitoring
title Interstitial fluid-based optical biosensors
title_full Interstitial fluid-based optical biosensors
title_fullStr Interstitial fluid-based optical biosensors
title_full_unstemmed Interstitial fluid-based optical biosensors
title_short Interstitial fluid-based optical biosensors
title_sort interstitial fluid based optical biosensors
topic Skin interstitial fluid
Microneedle
Colorimetric
Fluorometric
Diagnostics
Health monitoring
url http://www.sciencedirect.com/science/article/pii/S2949771X25000258
work_keys_str_mv AT atefehrahimzadeh interstitialfluidbasedopticalbiosensors
AT abrishamarjomandkhah interstitialfluidbasedopticalbiosensors
AT mohammadalikiani interstitialfluidbasedopticalbiosensors
AT hamedgolmohammadi interstitialfluidbasedopticalbiosensors