Gut microbiota-associated metabolites in metabolic diseases and their impact from food processing
Gut microbiota-associated metabolites can be synthesized endogenously or derived from dietary nutrients and host compounds. Among them, alkaloids, terpenes, and flavones originating from edible and medicinal foods have attracted remarkable interest recently and play crucial roles in metabolic diseas...
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| Format: | Article |
| Language: | English |
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Maximum Academic Press
2024-10-01
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| Series: | Food Innovation and Advances |
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| Online Access: | https://www.maxapress.com/article/doi/10.48130/fia-0024-0038 |
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| author | Aohuan Huang Qingping Wu Pongpol Thanuphol Larissa Leandro da Cruz Zhiqing Xie Mengfei Chen Fen Zhang Zhenjun Zhu Yu Ding |
| author_facet | Aohuan Huang Qingping Wu Pongpol Thanuphol Larissa Leandro da Cruz Zhiqing Xie Mengfei Chen Fen Zhang Zhenjun Zhu Yu Ding |
| author_sort | Aohuan Huang |
| collection | DOAJ |
| description | Gut microbiota-associated metabolites can be synthesized endogenously or derived from dietary nutrients and host compounds. Among them, alkaloids, terpenes, and flavones originating from edible and medicinal foods have attracted remarkable interest recently and play crucial roles in metabolic diseases. The efficacy of these metabolites is susceptible to dietary intervention, especially after food processing. Therefore, this review comprehensively summarizes the different sources of common gut microbial metabolites, including microbial self-synthesis, biodegradation of exogenous substances (mainly dietary nutrients), and participation in host metabolism. In addition, the latest studies on novel metabolites such as alkaloids, terpenoids, and flavonoids are discussed, and their action mechanisms on metabolic diseases are elaborated. How food processing impacts dietary nutrients and their metabolites is carefully examined, as well as their effects on disease modification. These insights could contribute to a deeper understanding of the mechanisms by which diet efficacy helps prevent metabolic diseases, particularly through gut microbial metabolites. |
| format | Article |
| id | doaj-art-9ec193dfc57143059f1fc258fa675b8c |
| institution | DOAJ |
| issn | 2836-774X |
| language | English |
| publishDate | 2024-10-01 |
| publisher | Maximum Academic Press |
| record_format | Article |
| series | Food Innovation and Advances |
| spelling | doaj-art-9ec193dfc57143059f1fc258fa675b8c2025-08-20T03:18:30ZengMaximum Academic PressFood Innovation and Advances2836-774X2024-10-013443844810.48130/fia-0024-0038fia-0024-0038Gut microbiota-associated metabolites in metabolic diseases and their impact from food processingAohuan Huang0Qingping Wu1Pongpol Thanuphol2Larissa Leandro da Cruz3Zhiqing Xie4Mengfei Chen5Fen Zhang6Zhenjun Zhu7Yu Ding8Department of Food Science and Engineering, College of Life Science and Technology, Jinan University, Guangzhou 510632, ChinaNational Health Commission Science and Technology lnnovation Platform for Nutrition and Safety of Microbial Food, Guangdong Provincial Key Laboratory of Microbial Safety and Health, State Key Laboratory of Applied Microbiology Southern China, Institute of Microbiology, Guangdong Academy of Sciences, Guangzhou 510070, ChinaDepartment of Food Chemistry, Faculty of Pharmacy, Mahidol University, Bangkok 10400, ThailandNutrition College, Estácio de Sá University, Campos dos Goytacazes, RJ 20261-063, BrazilDepartment of Food Science and Engineering, College of Life Science and Technology, Jinan University, Guangzhou 510632, ChinaDepartment of Food Science and Engineering, College of Life Science and Technology, Jinan University, Guangzhou 510632, ChinaDepartment of Food Science and Engineering, College of Life Science and Technology, Jinan University, Guangzhou 510632, ChinaDepartment of Food Science and Engineering, College of Life Science and Technology, Jinan University, Guangzhou 510632, ChinaDepartment of Food Science and Engineering, College of Life Science and Technology, Jinan University, Guangzhou 510632, ChinaGut microbiota-associated metabolites can be synthesized endogenously or derived from dietary nutrients and host compounds. Among them, alkaloids, terpenes, and flavones originating from edible and medicinal foods have attracted remarkable interest recently and play crucial roles in metabolic diseases. The efficacy of these metabolites is susceptible to dietary intervention, especially after food processing. Therefore, this review comprehensively summarizes the different sources of common gut microbial metabolites, including microbial self-synthesis, biodegradation of exogenous substances (mainly dietary nutrients), and participation in host metabolism. In addition, the latest studies on novel metabolites such as alkaloids, terpenoids, and flavonoids are discussed, and their action mechanisms on metabolic diseases are elaborated. How food processing impacts dietary nutrients and their metabolites is carefully examined, as well as their effects on disease modification. These insights could contribute to a deeper understanding of the mechanisms by which diet efficacy helps prevent metabolic diseases, particularly through gut microbial metabolites.https://www.maxapress.com/article/doi/10.48130/fia-0024-0038metabolitesgut microbiotametabolic diseasesfood processing |
| spellingShingle | Aohuan Huang Qingping Wu Pongpol Thanuphol Larissa Leandro da Cruz Zhiqing Xie Mengfei Chen Fen Zhang Zhenjun Zhu Yu Ding Gut microbiota-associated metabolites in metabolic diseases and their impact from food processing Food Innovation and Advances metabolites gut microbiota metabolic diseases food processing |
| title | Gut microbiota-associated metabolites in metabolic diseases and their impact from food processing |
| title_full | Gut microbiota-associated metabolites in metabolic diseases and their impact from food processing |
| title_fullStr | Gut microbiota-associated metabolites in metabolic diseases and their impact from food processing |
| title_full_unstemmed | Gut microbiota-associated metabolites in metabolic diseases and their impact from food processing |
| title_short | Gut microbiota-associated metabolites in metabolic diseases and their impact from food processing |
| title_sort | gut microbiota associated metabolites in metabolic diseases and their impact from food processing |
| topic | metabolites gut microbiota metabolic diseases food processing |
| url | https://www.maxapress.com/article/doi/10.48130/fia-0024-0038 |
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