BNP and Admission Glucose as In-Hospital Mortality Predictors in Non-ST Elevation Myocardial Infarction

Objectives. Admission hyperglycemia and B-type natriuretic peptide (BNP) are associated with mortality in acute coronary syndromes, but no study compares their prediction in-hospital death. Methods. Patients with non-ST-elevation myocardial infarction (NSTEMI), in-hospital mortality and two-year mor...

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Main Authors: Julio Yoshio Takada, Rogério Bicudo Ramos, Solange Desiree Avakian, Soane Mota dos Santos, José Antonio Franchini Ramires, Antonio de Pádua Mansur
Format: Article
Language:English
Published: Wiley 2012-01-01
Series:The Scientific World Journal
Online Access:http://dx.doi.org/10.1100/2012/397915
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author Julio Yoshio Takada
Rogério Bicudo Ramos
Solange Desiree Avakian
Soane Mota dos Santos
José Antonio Franchini Ramires
Antonio de Pádua Mansur
author_facet Julio Yoshio Takada
Rogério Bicudo Ramos
Solange Desiree Avakian
Soane Mota dos Santos
José Antonio Franchini Ramires
Antonio de Pádua Mansur
author_sort Julio Yoshio Takada
collection DOAJ
description Objectives. Admission hyperglycemia and B-type natriuretic peptide (BNP) are associated with mortality in acute coronary syndromes, but no study compares their prediction in-hospital death. Methods. Patients with non-ST-elevation myocardial infarction (NSTEMI), in-hospital mortality and two-year mortality or readmission were compared for area under the curve (AUC), sensitivity (SEN), specificity (SPE), positive predictive value (PPV), negative predictive value (NPV), and accuracy (ACC) of glycemia and BNP. Results. Respectively, AUC, SEN, SPE, PPV, NPV, and ACC for prediction of in-hospital mortality were 0.815, 71.4%, 84.3%, 26.3%, 97.4%, and 83.3% for glycemia = 200 mg/dL and 0.748, 71.4%, 68.5%, 15.2%, 96.8% and 68.7% for BNP = 300 pg/mL. AUC of glycemia was similar to BNP (P=0.411). In multivariate analysis we found glycemia ≥200mg/dL related to in-hospital death (P=0.004). No difference was found in two-year mortality or readmission in BNP or hyperglycemic subgroups. Conclusion. Hyperglycemia was an independent risk factor for in-hospital mortality in NSTEMI and had a good ROC curve level. Hyperglycemia and BNP, although poor in-hospital predictors of unfavorable events, were independent risk factors for death or length of stay >10 days. No relation was found between hyperglycemia or BNP and long-term events.
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spelling doaj-art-9ec191c5522c45a5ade5f8c21ddfe7ec2025-08-20T02:18:33ZengWileyThe Scientific World Journal1537-744X2012-01-01201210.1100/2012/397915397915BNP and Admission Glucose as In-Hospital Mortality Predictors in Non-ST Elevation Myocardial InfarctionJulio Yoshio Takada0Rogério Bicudo Ramos1Solange Desiree Avakian2Soane Mota dos Santos3José Antonio Franchini Ramires4Antonio de Pádua Mansur5Heart Institute (InCor), University of São Paulo Medical School, Avenue Enéas de Carvalho de Aguiar 44, 05403-000 São Paulo, SP, BrazilHeart Institute (InCor), University of São Paulo Medical School, Avenue Enéas de Carvalho de Aguiar 44, 05403-000 São Paulo, SP, BrazilHeart Institute (InCor), University of São Paulo Medical School, Avenue Enéas de Carvalho de Aguiar 44, 05403-000 São Paulo, SP, BrazilInstitute of Mathematics and Statistics, University of São Paulo, R. do Matão 1010, 05508-090 São Paulo, SP, BrazilHeart Institute (InCor), University of São Paulo Medical School, Avenue Enéas de Carvalho de Aguiar 44, 05403-000 São Paulo, SP, BrazilHeart Institute (InCor), University of São Paulo Medical School, Avenue Enéas de Carvalho de Aguiar 44, 05403-000 São Paulo, SP, BrazilObjectives. Admission hyperglycemia and B-type natriuretic peptide (BNP) are associated with mortality in acute coronary syndromes, but no study compares their prediction in-hospital death. Methods. Patients with non-ST-elevation myocardial infarction (NSTEMI), in-hospital mortality and two-year mortality or readmission were compared for area under the curve (AUC), sensitivity (SEN), specificity (SPE), positive predictive value (PPV), negative predictive value (NPV), and accuracy (ACC) of glycemia and BNP. Results. Respectively, AUC, SEN, SPE, PPV, NPV, and ACC for prediction of in-hospital mortality were 0.815, 71.4%, 84.3%, 26.3%, 97.4%, and 83.3% for glycemia = 200 mg/dL and 0.748, 71.4%, 68.5%, 15.2%, 96.8% and 68.7% for BNP = 300 pg/mL. AUC of glycemia was similar to BNP (P=0.411). In multivariate analysis we found glycemia ≥200mg/dL related to in-hospital death (P=0.004). No difference was found in two-year mortality or readmission in BNP or hyperglycemic subgroups. Conclusion. Hyperglycemia was an independent risk factor for in-hospital mortality in NSTEMI and had a good ROC curve level. Hyperglycemia and BNP, although poor in-hospital predictors of unfavorable events, were independent risk factors for death or length of stay >10 days. No relation was found between hyperglycemia or BNP and long-term events.http://dx.doi.org/10.1100/2012/397915
spellingShingle Julio Yoshio Takada
Rogério Bicudo Ramos
Solange Desiree Avakian
Soane Mota dos Santos
José Antonio Franchini Ramires
Antonio de Pádua Mansur
BNP and Admission Glucose as In-Hospital Mortality Predictors in Non-ST Elevation Myocardial Infarction
The Scientific World Journal
title BNP and Admission Glucose as In-Hospital Mortality Predictors in Non-ST Elevation Myocardial Infarction
title_full BNP and Admission Glucose as In-Hospital Mortality Predictors in Non-ST Elevation Myocardial Infarction
title_fullStr BNP and Admission Glucose as In-Hospital Mortality Predictors in Non-ST Elevation Myocardial Infarction
title_full_unstemmed BNP and Admission Glucose as In-Hospital Mortality Predictors in Non-ST Elevation Myocardial Infarction
title_short BNP and Admission Glucose as In-Hospital Mortality Predictors in Non-ST Elevation Myocardial Infarction
title_sort bnp and admission glucose as in hospital mortality predictors in non st elevation myocardial infarction
url http://dx.doi.org/10.1100/2012/397915
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