The therapeutic efficacy of mesenchymal stem cells and their extracellular vesicles in the treatment of diverse skin diseases
This review presents the current knowledge on the potential of mesenchymal stem cells (MSCs) and their extracellular vesicles (EVs) in the treatment of various skin diseases such as psoriasis, atopic dermatitis, contact dermatitis, systemic sclerosis, graft-versus-host disease, alopecia areata, and...
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Frontiers Media S.A.
2025-08-01
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| Series: | Frontiers in Immunology |
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| Online Access: | https://www.frontiersin.org/articles/10.3389/fimmu.2025.1626066/full |
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| author | Mateusz Matwiejuk Agnieszka Mikłosz Hanna Myśliwiec Adrian Chabowski Iwona Flisiak |
| author_facet | Mateusz Matwiejuk Agnieszka Mikłosz Hanna Myśliwiec Adrian Chabowski Iwona Flisiak |
| author_sort | Mateusz Matwiejuk |
| collection | DOAJ |
| description | This review presents the current knowledge on the potential of mesenchymal stem cells (MSCs) and their extracellular vesicles (EVs) in the treatment of various skin diseases such as psoriasis, atopic dermatitis, contact dermatitis, systemic sclerosis, graft-versus-host disease, alopecia areata, and systemic lupus erythematosus. MSCs can modulate the immune response and release growth factors and cytokines that promote tissue regeneration and healing and reduce inflammation. In turn, EVs’ ability to transport various biological molecules, including microRNAs (miRNAs), makes them potential therapeutic agents. Moreover, EVs have been shown to reduce scaling, thickness, and erythema in psoriasis. In atopic dermatitis, EVs can alleviate clinical symptoms, lower serum IgE levels, and reduce immune cell infiltration. Mesenchymal stem cells like bone marrow-derived mesenchymal stem cells (BM-MSCs) exert their immunomodulatory effects by directly targeting various immune cell populations, including T cells, B cells, dendritic cells, and natural killer (NK) cells. To fully realize the potential of EVs in clinical practice, further research is needed to conduct well-designed clinical trials to evaluate the safety and efficacy of EV-based therapies in different skin diseases. Overall, EVs have the potential to revolutionize the treatment of skin diseases by offering a targeted and effective approach to address various underlying mechanisms, although further large-scale studies are needed. |
| format | Article |
| id | doaj-art-9eb4ad2f68c94429a565b76074ceee63 |
| institution | Kabale University |
| issn | 1664-3224 |
| language | English |
| publishDate | 2025-08-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Immunology |
| spelling | doaj-art-9eb4ad2f68c94429a565b76074ceee632025-08-20T04:03:21ZengFrontiers Media S.A.Frontiers in Immunology1664-32242025-08-011610.3389/fimmu.2025.16260661626066The therapeutic efficacy of mesenchymal stem cells and their extracellular vesicles in the treatment of diverse skin diseasesMateusz Matwiejuk0Agnieszka Mikłosz1Hanna Myśliwiec2Adrian Chabowski3Iwona Flisiak4Department of Dermatology and Venereology, Medical University of Bialystok, Bialystok, PolandDepartment of Physiology, Medical University of Bialystok, Bialystok, PolandDepartment of Dermatology and Venereology, Medical University of Bialystok, Bialystok, PolandDepartment of Physiology, Medical University of Bialystok, Bialystok, PolandDepartment of Dermatology and Venereology, Medical University of Bialystok, Bialystok, PolandThis review presents the current knowledge on the potential of mesenchymal stem cells (MSCs) and their extracellular vesicles (EVs) in the treatment of various skin diseases such as psoriasis, atopic dermatitis, contact dermatitis, systemic sclerosis, graft-versus-host disease, alopecia areata, and systemic lupus erythematosus. MSCs can modulate the immune response and release growth factors and cytokines that promote tissue regeneration and healing and reduce inflammation. In turn, EVs’ ability to transport various biological molecules, including microRNAs (miRNAs), makes them potential therapeutic agents. Moreover, EVs have been shown to reduce scaling, thickness, and erythema in psoriasis. In atopic dermatitis, EVs can alleviate clinical symptoms, lower serum IgE levels, and reduce immune cell infiltration. Mesenchymal stem cells like bone marrow-derived mesenchymal stem cells (BM-MSCs) exert their immunomodulatory effects by directly targeting various immune cell populations, including T cells, B cells, dendritic cells, and natural killer (NK) cells. To fully realize the potential of EVs in clinical practice, further research is needed to conduct well-designed clinical trials to evaluate the safety and efficacy of EV-based therapies in different skin diseases. Overall, EVs have the potential to revolutionize the treatment of skin diseases by offering a targeted and effective approach to address various underlying mechanisms, although further large-scale studies are needed.https://www.frontiersin.org/articles/10.3389/fimmu.2025.1626066/fullextracellular vesiclesexosomesmesenchymal stem cellsskin diseasespsoriasisatopic dermatitis |
| spellingShingle | Mateusz Matwiejuk Agnieszka Mikłosz Hanna Myśliwiec Adrian Chabowski Iwona Flisiak The therapeutic efficacy of mesenchymal stem cells and their extracellular vesicles in the treatment of diverse skin diseases Frontiers in Immunology extracellular vesicles exosomes mesenchymal stem cells skin diseases psoriasis atopic dermatitis |
| title | The therapeutic efficacy of mesenchymal stem cells and their extracellular vesicles in the treatment of diverse skin diseases |
| title_full | The therapeutic efficacy of mesenchymal stem cells and their extracellular vesicles in the treatment of diverse skin diseases |
| title_fullStr | The therapeutic efficacy of mesenchymal stem cells and their extracellular vesicles in the treatment of diverse skin diseases |
| title_full_unstemmed | The therapeutic efficacy of mesenchymal stem cells and their extracellular vesicles in the treatment of diverse skin diseases |
| title_short | The therapeutic efficacy of mesenchymal stem cells and their extracellular vesicles in the treatment of diverse skin diseases |
| title_sort | therapeutic efficacy of mesenchymal stem cells and their extracellular vesicles in the treatment of diverse skin diseases |
| topic | extracellular vesicles exosomes mesenchymal stem cells skin diseases psoriasis atopic dermatitis |
| url | https://www.frontiersin.org/articles/10.3389/fimmu.2025.1626066/full |
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