KLF11 deficiency enhances chemokine generation and fibrosis in murine unilateral ureteral obstruction.

KLF11 deficiency enhances chemokine generation and fibrosis in murine unilateral ureteral obstruction.

Progression of virtually all forms of chronic kidney disease (CKD) is associated with activation of pro-inflammatory and pro-fibrotic signaling pathways. Despite extensive research, progress in identifying therapeutic targets to arrest or slow progression of CKD has been limited by incomplete unders...

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Main Authors: Silvana B De Lorenzo, Alyssa M Vrieze, Ruth A Johnson, Karen R Lien, Karl A Nath, Vesna D Garovic, Khashayarsha Khazaie, Joseph P Grande
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2022-01-01
Series:PLoS ONE
Online Access:https://journals.plos.org/plosone/article/file?id=10.1371/journal.pone.0266454&type=printable
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