The Role of Vitamin E in Enhancing the Efficacy of Tamoxifen on Sperm Parameters in Male Infertility: A Clinical Experimental Study
Objective: To compare the outcome of tamoxifen versus tamoxifen plus vitamin E on the semen quality of infertile males with abnormal semen parameters. Methods: This clinical experimental study was done in the Department of Obstetrics and Gynecology, Sharif Medical City, Lahore for 6 months after...
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University of Lahore
2025-06-01
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| Series: | Journal of University College of Medicine and Dentistry |
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| Online Access: | https://journals.uol.edu.pk/jucmd/article/view/4027 |
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| author | Shazia Tazion Fauzia Butt Sundas Zafar Zahida Zakir Hadia Zulfiqar Anees Fatima |
| author_facet | Shazia Tazion Fauzia Butt Sundas Zafar Zahida Zakir Hadia Zulfiqar Anees Fatima |
| author_sort | Shazia Tazion |
| collection | DOAJ |
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Objective: To compare the outcome of tamoxifen versus tamoxifen plus vitamin E on the semen quality of infertile males with abnormal semen parameters.
Methods: This clinical experimental study was done in the Department of Obstetrics and Gynecology, Sharif Medical City, Lahore for 6 months after approval from the hospital's ethical review board from January 15, 2024 till July 15, 2024. A total of 110 infertile males provided written consent and underwent semen analysis. Infertile married males aged 20 to 40 years and diagnosed with abnormal semen parameters were included in this study. Patients having leukocytospermia, diminished testicular volume, severe oligospermia were excluded from the study. Demographics and baseline data were recorded and participants were divided into group A which received oral Tamoxifen 10mg twice daily for three months, while Group B received Tamoxifen 10mg plus capsule vitamin E 400mg once a day orally. After three months, semen analysis was repeated to assess changes in sperm parameters. Data collection adhered to a pre-designed proforma.
Results: The mean age in both the groups was 29.40+3.89 years; sperm count in Group A increased from 6.13+0.92 to 16.31+1.33 and in Group B 6.16+0.90 to 19.83+1.58 (p=0.000), and motility increased from 13.98+1.00 to 30.58+2.13 in Group A and 14.05+1.04 to 34.69+1.90 in Group B, (p=0.001)
Conclusion: Our study findings strongly support the synergistic effect of combining tamoxifen with vitamin E in enhancing sperm motility, providing valuable insights for potential therapeutic interventions in male infertility.
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| format | Article |
| id | doaj-art-9eaf658627af4394a19b327680aaa664 |
| institution | DOAJ |
| issn | 2790-3443 2790-3451 |
| language | English |
| publishDate | 2025-06-01 |
| publisher | University of Lahore |
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| series | Journal of University College of Medicine and Dentistry |
| spelling | doaj-art-9eaf658627af4394a19b327680aaa6642025-08-20T02:40:07ZengUniversity of LahoreJournal of University College of Medicine and Dentistry2790-34432790-34512025-06-014210.51846/jucmd.v4i2.4027 The Role of Vitamin E in Enhancing the Efficacy of Tamoxifen on Sperm Parameters in Male Infertility: A Clinical Experimental StudyShazia Tazion0Fauzia Butt1Sundas Zafar2Zahida Zakir3Hadia Zulfiqar4Anees Fatima5Associate professor, Department of Obstetrics and Gynaecology, Sharif Medical & Dental College, Lahore, PakistanProfessor, Department of Obstetrics and Gynaecology, Sharif Medical & Dental College, Lahore, PakistanPost Graduate Trainee, Department of Obstetrics and Gynaecology, Sharif Medical & Dental College, Lahore, PakistanPost Graduate Trainee, Department of Obstetrics and Gynaecology, Sharif Medical & Dental College, Lahore, PakistanPost Graduate Trainee, Department of Obstetrics and Gynaecology, Sharif Medical & Dental College, Lahore, PakistanAssistant Professor, Department of Obstetrics and Gynaecology, Sharif Medical & Dental College, Lahore, Pakistan Objective: To compare the outcome of tamoxifen versus tamoxifen plus vitamin E on the semen quality of infertile males with abnormal semen parameters. Methods: This clinical experimental study was done in the Department of Obstetrics and Gynecology, Sharif Medical City, Lahore for 6 months after approval from the hospital's ethical review board from January 15, 2024 till July 15, 2024. A total of 110 infertile males provided written consent and underwent semen analysis. Infertile married males aged 20 to 40 years and diagnosed with abnormal semen parameters were included in this study. Patients having leukocytospermia, diminished testicular volume, severe oligospermia were excluded from the study. Demographics and baseline data were recorded and participants were divided into group A which received oral Tamoxifen 10mg twice daily for three months, while Group B received Tamoxifen 10mg plus capsule vitamin E 400mg once a day orally. After three months, semen analysis was repeated to assess changes in sperm parameters. Data collection adhered to a pre-designed proforma. Results: The mean age in both the groups was 29.40+3.89 years; sperm count in Group A increased from 6.13+0.92 to 16.31+1.33 and in Group B 6.16+0.90 to 19.83+1.58 (p=0.000), and motility increased from 13.98+1.00 to 30.58+2.13 in Group A and 14.05+1.04 to 34.69+1.90 in Group B, (p=0.001) Conclusion: Our study findings strongly support the synergistic effect of combining tamoxifen with vitamin E in enhancing sperm motility, providing valuable insights for potential therapeutic interventions in male infertility. https://journals.uol.edu.pk/jucmd/article/view/4027Male infertilityTamoxifenSemen AnalysisOligospermiaVitamin ESperm Motility |
| spellingShingle | Shazia Tazion Fauzia Butt Sundas Zafar Zahida Zakir Hadia Zulfiqar Anees Fatima The Role of Vitamin E in Enhancing the Efficacy of Tamoxifen on Sperm Parameters in Male Infertility: A Clinical Experimental Study Journal of University College of Medicine and Dentistry Male infertility Tamoxifen Semen Analysis Oligospermia Vitamin E Sperm Motility |
| title | The Role of Vitamin E in Enhancing the Efficacy of Tamoxifen on Sperm Parameters in Male Infertility: A Clinical Experimental Study |
| title_full | The Role of Vitamin E in Enhancing the Efficacy of Tamoxifen on Sperm Parameters in Male Infertility: A Clinical Experimental Study |
| title_fullStr | The Role of Vitamin E in Enhancing the Efficacy of Tamoxifen on Sperm Parameters in Male Infertility: A Clinical Experimental Study |
| title_full_unstemmed | The Role of Vitamin E in Enhancing the Efficacy of Tamoxifen on Sperm Parameters in Male Infertility: A Clinical Experimental Study |
| title_short | The Role of Vitamin E in Enhancing the Efficacy of Tamoxifen on Sperm Parameters in Male Infertility: A Clinical Experimental Study |
| title_sort | role of vitamin e in enhancing the efficacy of tamoxifen on sperm parameters in male infertility a clinical experimental study |
| topic | Male infertility Tamoxifen Semen Analysis Oligospermia Vitamin E Sperm Motility |
| url | https://journals.uol.edu.pk/jucmd/article/view/4027 |
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