18 F-FLT-PET for response evaluation of MEK inhibitor selumetinib (AZD6244, ARRY-142886) in patients with solid tumors

18 F-FLT-PET for response evaluation of MEK inhibitor selumetinib (AZD6244, ARRY-142886) in patients with solid tumors

Selumetinib (AZD6244, ARRY-142886) is a potent, selective, uncompetitive inhibitor of MEK 1 / 2, part of the RAF/MEK/ERK protein kinase signal cascade, which is responsible for tumor. This pilot study was used to explore if 18  F-fluoro-l-thymidine (FLT), a thymidine analogue positron emission tomog...

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Bibliographic Details
Main Authors: Ingrid Desar, Rozemarie Gilles, Carla van Herpen, Anja J. Timmer-Bonte, Mireille Cantarini, Winette van der Graaf, Wim Oyen
Format: Article
Language:English
Published: Thieme Medical and Scientific Publishers Pvt. Ltd. 2012-04-01
Series:World Journal of Nuclear Medicine
Subjects:
f-18 flt
pet-ct
selumetinib
treatment response
Online Access:http://www.thieme-connect.de/DOI/DOI?10.4103/1450-1147.103413
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