Effect of lanthanum carbonate on coronal artery calcification in maintenance hemodialysis patients
Objective Coronary artery calcification(CAC) was strongly associated with future cardiovascular events,and has been identified as a strong independent predictor for cardiovascular mortality in patients undergoing maintenance hemodialysis(MHD).The purpose of this study was to explore the effect of la...
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| Main Authors: | , , , , , , , |
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| Format: | Article |
| Language: | zho |
| Published: |
Editorial Department of Journal of Clinical Nephrology
2015-01-01
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| Series: | Linchuang shenzangbing zazhi |
| Subjects: | |
| Online Access: | http://www.lcszb.com/thesisDetails?columnId=57919962&Fpath=home&index=0 |
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| Summary: | Objective Coronary artery calcification(CAC) was strongly associated with future cardiovascular events,and has been identified as a strong independent predictor for cardiovascular mortality in patients undergoing maintenance hemodialysis(MHD).The purpose of this study was to explore the effect of lanthanum on coronal artery calcification in MHD patients.Methods Fifty patients undergoing MHD were randomly divided into 2 groups,receiving either calcium acetate or lanthanum carbonate,and the CAC scores were evaluated by multi-slice spiral CT(MSCT) scan at study enrollment and after 12-month treatment period.Progression of CAC was assessed,and serum levels of Ca,Pi,and intact parathyroid hormone(iPTH) were determined.Results Forty-seven patients completed the study.During this 12-month period,the serum phosphate level was decreased significantly from(2.23 ± 0.33) mmol/L to(1.55 ± 0.38) mmol/L in the calcium acetate group(P<0.05),and similarly decreased from(2.30 ± 0.34) mmol/L to(1.54 ± 0.32) mmol/L in the lanthanum carbonate group(P<0.05).Changes in serum phosphate level between two groups were not significantly different(P>0.05).The serum calcium level showed a significant increase in the calcium acetate group[(2.33 ± 0.20) mmol/L at baseline and(2.46 ± 0.22) mmol/L at study completion,P<0.05],but no significant change in the lanthanum carbonate group[(2.39 ± 0.23) mmol/L at baseline and(2.25 ±0.18) mmol/L at study completion,P>0.05].Changes in serum calcium level between two groups showed significant difference(P<0.05).The CACs showed a significant increase in the calcium acetate group[(1 123 ±998) at baseline and(1 306 ± 1 286) at study completion,P<0.05],but no significant change was found in the lanthanum carbonate group[(1 216 ± 1 033) at baseline and(1 190 ± 822) at study completion,P>0.05].Changes in CACs were significantly smaller in lanthanum carbonate group than in calcium acetate group(P<0.05).Conclusions Lanthanum carbonate or calcium acetate is similarly effective in decreasing serum phosphate level,whereas the former shows significant advantages in controlling serum calcium level and delaying progression of CAC in patients undergoing MHD over the latter. |
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| ISSN: | 1671-2390 |