Expanding the inhibitor space of the WWP1 and WWP2 HECT E3 ligases

Expanding the inhibitor space of the WWP1 and WWP2 HECT E3 ligases

The HECT E3 ubiquitin ligases 1 (WWP1) and 2 (WWP2) are responsible for the ubiquitin-mediated degradation of key tumour suppressor proteins and are dysregulated in various cancers and diseases. Here we expand their limited inhibitor space by identification of NSC-217913 displaying a WWP1 IC50 of 15...

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Bibliographic Details
Main Authors: Ashley P. Dudey, Jake M. Rigby, Gregory R. Hughes, G. Richard Stephenson, Thomas E. Storr, Andrew Chantry, Andrew M. Hemmings
Format: Article
Language:English
Published: Taylor & Francis Group 2024-12-01
Series:Journal of Enzyme Inhibition and Medicinal Chemistry
Subjects:
ubiquitin ligase inhibitors
drug discovery
SAR
WWP1
WWP2
Online Access:https://www.tandfonline.com/doi/10.1080/14756366.2024.2394895
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