Influence of CAG Repeat Polymorphism on the Targets of Testosterone Action
In the last decade, ample evidence has demonstrated the growing importance of androgen receptor (AR) CAG repeat polymorphism in andrology. This genetic parameter is able to condition the peripheral effects of testosterone and therefore to influence male sexual function and fertility, cardiovascular...
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| Main Authors: | , , , , , , , , , , , , |
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| Format: | Article |
| Language: | English |
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Wiley
2015-01-01
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| Series: | International Journal of Endocrinology |
| Online Access: | http://dx.doi.org/10.1155/2015/298107 |
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| author | Giacomo Tirabassi Angelo Cignarelli Sebastio Perrini Nicola delli Muti Giorgio Furlani Mariagrazia Gallo Francesco Pallotti Donatella Paoli Francesco Giorgino Francesco Lombardo Loredana Gandini Andrea Lenzi Giancarlo Balercia |
| author_facet | Giacomo Tirabassi Angelo Cignarelli Sebastio Perrini Nicola delli Muti Giorgio Furlani Mariagrazia Gallo Francesco Pallotti Donatella Paoli Francesco Giorgino Francesco Lombardo Loredana Gandini Andrea Lenzi Giancarlo Balercia |
| author_sort | Giacomo Tirabassi |
| collection | DOAJ |
| description | In the last decade, ample evidence has demonstrated the growing importance of androgen receptor (AR) CAG repeat polymorphism in andrology. This genetic parameter is able to condition the peripheral effects of testosterone and therefore to influence male sexual function and fertility, cardiovascular risk, body composition, bone metabolism, the risk of prostate and testicular cancer, the psychiatric status, and the onset of neurodegenerative disorders. In this review, we extensively discuss the literature data and identify a role for AR CAG repeat polymorphism in conditioning the systemic testosterone effects. In particular, our main purpose was to provide an updated text able to shed light on the many and often contradictory findings reporting an influence of CAG repeat polymorphism on the targets of testosterone action. |
| format | Article |
| id | doaj-art-9ea445d016a24ce3ab309627acd5710b |
| institution | OA Journals |
| issn | 1687-8337 1687-8345 |
| language | English |
| publishDate | 2015-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | International Journal of Endocrinology |
| spelling | doaj-art-9ea445d016a24ce3ab309627acd5710b2025-08-20T02:18:31ZengWileyInternational Journal of Endocrinology1687-83371687-83452015-01-01201510.1155/2015/298107298107Influence of CAG Repeat Polymorphism on the Targets of Testosterone ActionGiacomo Tirabassi0Angelo Cignarelli1Sebastio Perrini2Nicola delli Muti3Giorgio Furlani4Mariagrazia Gallo5Francesco Pallotti6Donatella Paoli7Francesco Giorgino8Francesco Lombardo9Loredana Gandini10Andrea Lenzi11Giancarlo Balercia12Division of Endocrinology, Department of Clinical and Molecular Sciences, Umberto I Hospital, Polytechnic University of Marche, Via Conca 71, 60126 Ancona, ItalyDepartment of Emergency and Organ Transplantation, Section of Internal Medicine, Endocrinology, Andrology, and Metabolic Diseases, University of Bari Aldo Moro, Piazza Giulio Cesare 11, 70124 Bari, ItalyDepartment of Emergency and Organ Transplantation, Section of Internal Medicine, Endocrinology, Andrology, and Metabolic Diseases, University of Bari Aldo Moro, Piazza Giulio Cesare 11, 70124 Bari, ItalyDivision of Endocrinology, Department of Clinical and Molecular Sciences, Umberto I Hospital, Polytechnic University of Marche, Via Conca 71, 60126 Ancona, ItalyDivision of Endocrinology, Department of Clinical and Molecular Sciences, Umberto I Hospital, Polytechnic University of Marche, Via Conca 71, 60126 Ancona, ItalyLaboratory of Seminology-Sperm Bank, Department of Experimental Medicine, University of Rome “La Sapienza”, Viale del Policlinico 155, 00161 Rome, ItalyLaboratory of Seminology-Sperm Bank, Department of Experimental Medicine, University of Rome “La Sapienza”, Viale del Policlinico 155, 00161 Rome, ItalyLaboratory of Seminology-Sperm Bank, Department of Experimental Medicine, University of Rome “La Sapienza”, Viale del Policlinico 155, 00161 Rome, ItalyDepartment of Emergency and Organ Transplantation, Section of Internal Medicine, Endocrinology, Andrology, and Metabolic Diseases, University of Bari Aldo Moro, Piazza Giulio Cesare 11, 70124 Bari, ItalyLaboratory of Seminology-Sperm Bank, Department of Experimental Medicine, University of Rome “La Sapienza”, Viale del Policlinico 155, 00161 Rome, ItalyLaboratory of Seminology-Sperm Bank, Department of Experimental Medicine, University of Rome “La Sapienza”, Viale del Policlinico 155, 00161 Rome, ItalyLaboratory of Seminology-Sperm Bank, Department of Experimental Medicine, University of Rome “La Sapienza”, Viale del Policlinico 155, 00161 Rome, ItalyDivision of Endocrinology, Department of Clinical and Molecular Sciences, Umberto I Hospital, Polytechnic University of Marche, Via Conca 71, 60126 Ancona, ItalyIn the last decade, ample evidence has demonstrated the growing importance of androgen receptor (AR) CAG repeat polymorphism in andrology. This genetic parameter is able to condition the peripheral effects of testosterone and therefore to influence male sexual function and fertility, cardiovascular risk, body composition, bone metabolism, the risk of prostate and testicular cancer, the psychiatric status, and the onset of neurodegenerative disorders. In this review, we extensively discuss the literature data and identify a role for AR CAG repeat polymorphism in conditioning the systemic testosterone effects. In particular, our main purpose was to provide an updated text able to shed light on the many and often contradictory findings reporting an influence of CAG repeat polymorphism on the targets of testosterone action.http://dx.doi.org/10.1155/2015/298107 |
| spellingShingle | Giacomo Tirabassi Angelo Cignarelli Sebastio Perrini Nicola delli Muti Giorgio Furlani Mariagrazia Gallo Francesco Pallotti Donatella Paoli Francesco Giorgino Francesco Lombardo Loredana Gandini Andrea Lenzi Giancarlo Balercia Influence of CAG Repeat Polymorphism on the Targets of Testosterone Action International Journal of Endocrinology |
| title | Influence of CAG Repeat Polymorphism on the Targets of Testosterone Action |
| title_full | Influence of CAG Repeat Polymorphism on the Targets of Testosterone Action |
| title_fullStr | Influence of CAG Repeat Polymorphism on the Targets of Testosterone Action |
| title_full_unstemmed | Influence of CAG Repeat Polymorphism on the Targets of Testosterone Action |
| title_short | Influence of CAG Repeat Polymorphism on the Targets of Testosterone Action |
| title_sort | influence of cag repeat polymorphism on the targets of testosterone action |
| url | http://dx.doi.org/10.1155/2015/298107 |
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