A novel PNIPAM-Modified polyurethane/carboxymethyl cellulose photo-thermoresponsive hydrogel loaded with gemcitabine to suppress esophageal cancer cells via VEGF-mediated angiogenic pathway inhibition

A novel PNIPAM-Modified polyurethane/carboxymethyl cellulose photo-thermoresponsive hydrogel loaded with gemcitabine to suppress esophageal cancer cells via VEGF-mediated angiogenic pathway inhibition

Abstract This study reports the development of a thermoresponsive hydrogel composed of poly(N-isopropylacrylamide)-modified polyurethane (PNIPAM-PU) and carboxymethyl cellulose (CMC) for the controlled delivery of gemcitabine (GEM) in esophageal cancer treatment. Characterization by XRD and FTIR con...

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Bibliographic Details
Main Authors: Shirong Wu, Huachuan Zhang, Yu Zhang, Ya Zhao, Mengqi Xiang, Liqiong Hao, Jing Chen
Format: Article
Language:English
Published: BMC 2025-07-01
Series:Journal of Biological Engineering
Subjects:
Carboxymethyl cellulose
PNIPAM
Eesophageal cancer
Apoptosis
Online Access:https://doi.org/10.1186/s13036-025-00530-y
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