Sleep disturbance in clinical and preclinical scrapie-infected sheep measured by polysomnography
Neurodegenerative diseases are characterised by neuronal loss and abnormal deposition of pathological proteins in the nervous system. Among the most common neurodegenerative diseases are Alzheimer’s disease (AD), Parkinson’s disease (PD), Huntington’s disease and transmissible spongiform encephalopa...
Saved in:
| Main Authors: | , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Taylor & Francis Group
2024-12-01
|
| Series: | Veterinary Quarterly |
| Subjects: | |
| Online Access: | https://www.tandfonline.com/doi/10.1080/01652176.2024.2349674 |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
| _version_ | 1850060311660331008 |
|---|---|
| author | Diego Sola Fraca Ernesto Sánchez Garrigós Jorge de Francisco Moure Belén Marín Gonzalez Juan José Badiola Díez Cristina Acín Tresaco |
| author_facet | Diego Sola Fraca Ernesto Sánchez Garrigós Jorge de Francisco Moure Belén Marín Gonzalez Juan José Badiola Díez Cristina Acín Tresaco |
| author_sort | Diego Sola Fraca |
| collection | DOAJ |
| description | Neurodegenerative diseases are characterised by neuronal loss and abnormal deposition of pathological proteins in the nervous system. Among the most common neurodegenerative diseases are Alzheimer’s disease (AD), Parkinson’s disease (PD), Huntington’s disease and transmissible spongiform encephalopathies (TSEs). Sleep and circadian rhythm disturbances are one of the most common symptoms in patients with neurodegenerative diseases. Currently, one of the main objectives in the study of TSEs is to try to establish an early diagnosis, as clinical signs do not appear until the damage to the central nervous system is very advanced, which prevents any therapeutic approach. In this paper, we provide the first description of sleep disturbance caused by classical scrapie in clinical and preclinical sheep using polysomnography compared to healthy controls. Fifteen sheep classified into three groups, clinical, preclinical and negative control, were analysed. The results show a decrease in total sleep time as the disease progresses, with significant changes between control, clinical and pre-clinical animals. The results also show an increase in sleep fragmentation in clinical animals compared to preclinical and control animals. In addition, sheep with clinical scrapie show a total loss of Rapid Eye Movement sleep (REM) and alterations in Non Rapid Eyes Movement sleep (NREM) compared to control sheep, demonstrating more shallow sleep. Although further research is needed, these results suggest that prion diseases also produce sleep disturbances in animals and that polysomnography could be a diagnostic tool of interest in clinical and preclinical cases of prion diseases. |
| format | Article |
| id | doaj-art-9ea21e1ad1a14fa6b73ee4a5418e465d |
| institution | DOAJ |
| issn | 0165-2176 1875-5941 |
| language | English |
| publishDate | 2024-12-01 |
| publisher | Taylor & Francis Group |
| record_format | Article |
| series | Veterinary Quarterly |
| spelling | doaj-art-9ea21e1ad1a14fa6b73ee4a5418e465d2025-08-20T02:50:37ZengTaylor & Francis GroupVeterinary Quarterly0165-21761875-59412024-12-014411910.1080/01652176.2024.2349674Sleep disturbance in clinical and preclinical scrapie-infected sheep measured by polysomnographyDiego Sola Fraca0Ernesto Sánchez Garrigós1Jorge de Francisco Moure2Belén Marín Gonzalez3Juan José Badiola Díez4Cristina Acín Tresaco5Centro de Encefalopatías y Enfermedades Transmisibles Emergentes, Universidad de Zaragoza, IA2, IIS Aragón, Zaragoza, SpainServicio de Neurofisiología Clínica, Hospital Universitario Miguel Servet, Zaragoza, SpainServicio de Neurofisiología Clínica, Hospital Universitario Miguel Servet, Zaragoza, SpainCentro de Encefalopatías y Enfermedades Transmisibles Emergentes, Universidad de Zaragoza, IA2, IIS Aragón, Zaragoza, SpainCentro de Encefalopatías y Enfermedades Transmisibles Emergentes, Universidad de Zaragoza, IA2, IIS Aragón, Zaragoza, SpainCentro de Encefalopatías y Enfermedades Transmisibles Emergentes, Universidad de Zaragoza, IA2, IIS Aragón, Zaragoza, SpainNeurodegenerative diseases are characterised by neuronal loss and abnormal deposition of pathological proteins in the nervous system. Among the most common neurodegenerative diseases are Alzheimer’s disease (AD), Parkinson’s disease (PD), Huntington’s disease and transmissible spongiform encephalopathies (TSEs). Sleep and circadian rhythm disturbances are one of the most common symptoms in patients with neurodegenerative diseases. Currently, one of the main objectives in the study of TSEs is to try to establish an early diagnosis, as clinical signs do not appear until the damage to the central nervous system is very advanced, which prevents any therapeutic approach. In this paper, we provide the first description of sleep disturbance caused by classical scrapie in clinical and preclinical sheep using polysomnography compared to healthy controls. Fifteen sheep classified into three groups, clinical, preclinical and negative control, were analysed. The results show a decrease in total sleep time as the disease progresses, with significant changes between control, clinical and pre-clinical animals. The results also show an increase in sleep fragmentation in clinical animals compared to preclinical and control animals. In addition, sheep with clinical scrapie show a total loss of Rapid Eye Movement sleep (REM) and alterations in Non Rapid Eyes Movement sleep (NREM) compared to control sheep, demonstrating more shallow sleep. Although further research is needed, these results suggest that prion diseases also produce sleep disturbances in animals and that polysomnography could be a diagnostic tool of interest in clinical and preclinical cases of prion diseases.https://www.tandfonline.com/doi/10.1080/01652176.2024.2349674Prionneurodegenerative diseasesTSEsleep disorderssheep |
| spellingShingle | Diego Sola Fraca Ernesto Sánchez Garrigós Jorge de Francisco Moure Belén Marín Gonzalez Juan José Badiola Díez Cristina Acín Tresaco Sleep disturbance in clinical and preclinical scrapie-infected sheep measured by polysomnography Veterinary Quarterly Prion neurodegenerative diseases TSE sleep disorders sheep |
| title | Sleep disturbance in clinical and preclinical scrapie-infected sheep measured by polysomnography |
| title_full | Sleep disturbance in clinical and preclinical scrapie-infected sheep measured by polysomnography |
| title_fullStr | Sleep disturbance in clinical and preclinical scrapie-infected sheep measured by polysomnography |
| title_full_unstemmed | Sleep disturbance in clinical and preclinical scrapie-infected sheep measured by polysomnography |
| title_short | Sleep disturbance in clinical and preclinical scrapie-infected sheep measured by polysomnography |
| title_sort | sleep disturbance in clinical and preclinical scrapie infected sheep measured by polysomnography |
| topic | Prion neurodegenerative diseases TSE sleep disorders sheep |
| url | https://www.tandfonline.com/doi/10.1080/01652176.2024.2349674 |
| work_keys_str_mv | AT diegosolafraca sleepdisturbanceinclinicalandpreclinicalscrapieinfectedsheepmeasuredbypolysomnography AT ernestosanchezgarrigos sleepdisturbanceinclinicalandpreclinicalscrapieinfectedsheepmeasuredbypolysomnography AT jorgedefranciscomoure sleepdisturbanceinclinicalandpreclinicalscrapieinfectedsheepmeasuredbypolysomnography AT belenmaringonzalez sleepdisturbanceinclinicalandpreclinicalscrapieinfectedsheepmeasuredbypolysomnography AT juanjosebadioladiez sleepdisturbanceinclinicalandpreclinicalscrapieinfectedsheepmeasuredbypolysomnography AT cristinaacintresaco sleepdisturbanceinclinicalandpreclinicalscrapieinfectedsheepmeasuredbypolysomnography |