IL-33-Pretreated Mesenchymal Stem Cells Attenuate Acute Liver Failure by Improving Homing and Polarizing M2 Macrophages
Mesenchymal stem cells (MSCs) are highly effective in the treatment of acute liver failure (ALF). The efficacy of MSCs is closely related to the inflammatory environment. Therefore, we investigated the functional changes of MSCs in response to interleukin-33 (IL-33) stimulation. The results showed t...
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| Main Authors: | , , , , , , , , , |
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| Format: | Article |
| Language: | English |
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Wiley
2024-01-01
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| Series: | Stem Cells International |
| Online Access: | http://dx.doi.org/10.1155/2024/1273099 |
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| author | Hui Yuan Yuwen Li Zihao Kong Linya Peng Jiali Song Xiaoxue Hou Wen Zhang Rui Liu Tiantong Feng Chuanlong Zhu |
| author_facet | Hui Yuan Yuwen Li Zihao Kong Linya Peng Jiali Song Xiaoxue Hou Wen Zhang Rui Liu Tiantong Feng Chuanlong Zhu |
| author_sort | Hui Yuan |
| collection | DOAJ |
| description | Mesenchymal stem cells (MSCs) are highly effective in the treatment of acute liver failure (ALF). The efficacy of MSCs is closely related to the inflammatory environment. Therefore, we investigated the functional changes of MSCs in response to interleukin-33 (IL-33) stimulation. The results showed that bone marrow mesenchymal stem cells (BMSCs) pretreated with IL-33 had increased CCR2 expression, targeted CCL2 in the injured liver tissue, and improved the migration ability. Under LPS stimulation, the NF-κB pathway of BMDM was activated, and its phenotype polarized to the M1-type, while BMSCs pretreated with IL-33 inhibited the NF-κB pathway and enhanced M2 macrophage polarization. The M2-type macrophages could further inhibit hepatocytes inflammation, reduce hepatocytes apoptosis, and promote hepatocytes repair. These results suggest that IL-33 can enhance the efficacy of BMSCs in ALF and provide a new strategy for cell therapy of liver diseases. |
| format | Article |
| id | doaj-art-9ea1d6dc77284095bbe4d4154c3c8398 |
| institution | OA Journals |
| issn | 1687-9678 |
| language | English |
| publishDate | 2024-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Stem Cells International |
| spelling | doaj-art-9ea1d6dc77284095bbe4d4154c3c83982025-08-20T02:18:31ZengWileyStem Cells International1687-96782024-01-01202410.1155/2024/1273099IL-33-Pretreated Mesenchymal Stem Cells Attenuate Acute Liver Failure by Improving Homing and Polarizing M2 MacrophagesHui Yuan0Yuwen Li1Zihao Kong2Linya Peng3Jiali Song4Xiaoxue Hou5Wen Zhang6Rui Liu7Tiantong Feng8Chuanlong Zhu9Department of Infectious DiseaseDepartment of PediatricsDepartment of GastroenterologyDepartment of Infectious DiseaseDepartment of Infectious DiseaseDepartment of Infectious DiseaseDepartment of Infectious DiseaseDepartment of Infectious and Tropical DiseasesDepartment of Infectious DiseaseDepartment of Infectious DiseaseMesenchymal stem cells (MSCs) are highly effective in the treatment of acute liver failure (ALF). The efficacy of MSCs is closely related to the inflammatory environment. Therefore, we investigated the functional changes of MSCs in response to interleukin-33 (IL-33) stimulation. The results showed that bone marrow mesenchymal stem cells (BMSCs) pretreated with IL-33 had increased CCR2 expression, targeted CCL2 in the injured liver tissue, and improved the migration ability. Under LPS stimulation, the NF-κB pathway of BMDM was activated, and its phenotype polarized to the M1-type, while BMSCs pretreated with IL-33 inhibited the NF-κB pathway and enhanced M2 macrophage polarization. The M2-type macrophages could further inhibit hepatocytes inflammation, reduce hepatocytes apoptosis, and promote hepatocytes repair. These results suggest that IL-33 can enhance the efficacy of BMSCs in ALF and provide a new strategy for cell therapy of liver diseases.http://dx.doi.org/10.1155/2024/1273099 |
| spellingShingle | Hui Yuan Yuwen Li Zihao Kong Linya Peng Jiali Song Xiaoxue Hou Wen Zhang Rui Liu Tiantong Feng Chuanlong Zhu IL-33-Pretreated Mesenchymal Stem Cells Attenuate Acute Liver Failure by Improving Homing and Polarizing M2 Macrophages Stem Cells International |
| title | IL-33-Pretreated Mesenchymal Stem Cells Attenuate Acute Liver Failure by Improving Homing and Polarizing M2 Macrophages |
| title_full | IL-33-Pretreated Mesenchymal Stem Cells Attenuate Acute Liver Failure by Improving Homing and Polarizing M2 Macrophages |
| title_fullStr | IL-33-Pretreated Mesenchymal Stem Cells Attenuate Acute Liver Failure by Improving Homing and Polarizing M2 Macrophages |
| title_full_unstemmed | IL-33-Pretreated Mesenchymal Stem Cells Attenuate Acute Liver Failure by Improving Homing and Polarizing M2 Macrophages |
| title_short | IL-33-Pretreated Mesenchymal Stem Cells Attenuate Acute Liver Failure by Improving Homing and Polarizing M2 Macrophages |
| title_sort | il 33 pretreated mesenchymal stem cells attenuate acute liver failure by improving homing and polarizing m2 macrophages |
| url | http://dx.doi.org/10.1155/2024/1273099 |
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