Candida tropicalis arthritis of the knee in a child on chemotherapy treated with intra-articular amphotericin B
Fungal osteoarticular infections are rare but severe life-threatening infections, commonly in patients with risk factors such as in the setting of immunosuppression, indwelling prosthesis or intravenous substance abuse. Marked improvement in diagnostic techniques have also contributed to their early...
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| Format: | Article |
| Language: | English |
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Elsevier
2025-03-01
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| Series: | Journal of Orthopaedic Reports |
| Online Access: | http://www.sciencedirect.com/science/article/pii/S2773157X24000560 |
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| author | Xin Yang Tan Natalie Woon-Hui Tan Rina Yue Ling Ong Michaela Su-Fern Seng Kenneth Pak Leung Wong |
| author_facet | Xin Yang Tan Natalie Woon-Hui Tan Rina Yue Ling Ong Michaela Su-Fern Seng Kenneth Pak Leung Wong |
| author_sort | Xin Yang Tan |
| collection | DOAJ |
| description | Fungal osteoarticular infections are rare but severe life-threatening infections, commonly in patients with risk factors such as in the setting of immunosuppression, indwelling prosthesis or intravenous substance abuse. Marked improvement in diagnostic techniques have also contributed to their early detection. Candida species remains the most common cause of fungal osteoarticular infections. While systemic antifungal therapy and surgical drainage remain the mainstay of therapy, intra-articular instillation of antifungals may present a useful adjunct therapy to achieve articular antifungal concentrations. Herein we report a case of a 9-year-old male child with a case of Candida tropicalis septic arthritis of the knee, and our subsequent treatment regimen. This paper also aims to summarise the available evidence surrounding the use of intra-articular instillation of antifungals as adjunct for the treatment of fungal arthritis and highlights the need to further evaluate and develop a standardised treatment regimen. |
| format | Article |
| id | doaj-art-9ea0e28ccf6746ad8e862753ccb779d9 |
| institution | Kabale University |
| issn | 2773-157X |
| language | English |
| publishDate | 2025-03-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Journal of Orthopaedic Reports |
| spelling | doaj-art-9ea0e28ccf6746ad8e862753ccb779d92025-08-20T03:42:19ZengElsevierJournal of Orthopaedic Reports2773-157X2025-03-014110036110.1016/j.jorep.2024.100361Candida tropicalis arthritis of the knee in a child on chemotherapy treated with intra-articular amphotericin BXin Yang Tan0Natalie Woon-Hui Tan1Rina Yue Ling Ong2Michaela Su-Fern Seng3Kenneth Pak Leung Wong4Department of Orthopaedic Surgery, KK Women's and Children's Hospital, Singapore; Corresponding author.Infectious Disease Service, Department of Paediatrics, KK Women's and Children's Hospital, Singapore; Duke-NUS Medical School, Singapore; Yong Loo Lin School of Medicine, National University of Singapore, SingaporeDepartment of Pharmacy, KK Women's and Children's Hospital, SingaporeDepartment of Haematology/Oncology, KK Women's and Children's Hospital, Singapore; Duke-NUS Medical School, SingaporeDepartment of Orthopaedic Surgery, KK Women's and Children's Hospital, Singapore; Duke-NUS Medical School, Singapore; Yong Loo Lin School of Medicine, National University of Singapore, SingaporeFungal osteoarticular infections are rare but severe life-threatening infections, commonly in patients with risk factors such as in the setting of immunosuppression, indwelling prosthesis or intravenous substance abuse. Marked improvement in diagnostic techniques have also contributed to their early detection. Candida species remains the most common cause of fungal osteoarticular infections. While systemic antifungal therapy and surgical drainage remain the mainstay of therapy, intra-articular instillation of antifungals may present a useful adjunct therapy to achieve articular antifungal concentrations. Herein we report a case of a 9-year-old male child with a case of Candida tropicalis septic arthritis of the knee, and our subsequent treatment regimen. This paper also aims to summarise the available evidence surrounding the use of intra-articular instillation of antifungals as adjunct for the treatment of fungal arthritis and highlights the need to further evaluate and develop a standardised treatment regimen.http://www.sciencedirect.com/science/article/pii/S2773157X24000560 |
| spellingShingle | Xin Yang Tan Natalie Woon-Hui Tan Rina Yue Ling Ong Michaela Su-Fern Seng Kenneth Pak Leung Wong Candida tropicalis arthritis of the knee in a child on chemotherapy treated with intra-articular amphotericin B Journal of Orthopaedic Reports |
| title | Candida tropicalis arthritis of the knee in a child on chemotherapy treated with intra-articular amphotericin B |
| title_full | Candida tropicalis arthritis of the knee in a child on chemotherapy treated with intra-articular amphotericin B |
| title_fullStr | Candida tropicalis arthritis of the knee in a child on chemotherapy treated with intra-articular amphotericin B |
| title_full_unstemmed | Candida tropicalis arthritis of the knee in a child on chemotherapy treated with intra-articular amphotericin B |
| title_short | Candida tropicalis arthritis of the knee in a child on chemotherapy treated with intra-articular amphotericin B |
| title_sort | candida tropicalis arthritis of the knee in a child on chemotherapy treated with intra articular amphotericin b |
| url | http://www.sciencedirect.com/science/article/pii/S2773157X24000560 |
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