Discovery of therapeutic targets in cardiovascular diseases using high-throughput chromosome conformation capture (Hi-C)
Epigenetic changes have been associated with several cardiovascular diseases. In recent years, epigenetic inheritance based on spatial changes has gradually attracted attention. Alterations in three-dimensional chromatin structures have been shown to regulate gene expression and influence disease on...
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2025-03-01
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| Series: | Frontiers in Genetics |
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| Online Access: | https://www.frontiersin.org/articles/10.3389/fgene.2025.1515010/full |
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| author | Quan Zheng Ying Liu Ying Liu Minghao Guo Xin Zhang Qingbin Zhang Xi-Yong Yu Zhongxiao Lin |
| author_facet | Quan Zheng Ying Liu Ying Liu Minghao Guo Xin Zhang Qingbin Zhang Xi-Yong Yu Zhongxiao Lin |
| author_sort | Quan Zheng |
| collection | DOAJ |
| description | Epigenetic changes have been associated with several cardiovascular diseases. In recent years, epigenetic inheritance based on spatial changes has gradually attracted attention. Alterations in three-dimensional chromatin structures have been shown to regulate gene expression and influence disease onset and progression. High-throughput Chromosome Conformation Capture (Hi-C) is a powerful method to detect spatial chromatin conformation changes. Since its development, Hi-C technology has been widely adopted for discovering novel therapeutic targets in cardiovascular research. In this review, we summarize key targets identified by Hi-C in cardiovascular diseases and discuss their potential implications for epigenetic therapy. |
| format | Article |
| id | doaj-art-9e9f8e0c65d14bcaa3a7a66bf3490207 |
| institution | DOAJ |
| issn | 1664-8021 |
| language | English |
| publishDate | 2025-03-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Genetics |
| spelling | doaj-art-9e9f8e0c65d14bcaa3a7a66bf34902072025-08-20T02:52:38ZengFrontiers Media S.A.Frontiers in Genetics1664-80212025-03-011610.3389/fgene.2025.15150101515010Discovery of therapeutic targets in cardiovascular diseases using high-throughput chromosome conformation capture (Hi-C)Quan Zheng0Ying Liu1Ying Liu2Minghao Guo3Xin Zhang4Qingbin Zhang5Xi-Yong Yu6Zhongxiao Lin7School of Pharmacy, Macau University of Science and Technology, Taipa, ChinaSchool of Pharmacy, Macau University of Science and Technology, Taipa, ChinaDepartment of Pharmacology, School of Pharmacy, Guangzhou Xinhua University, Guangzhou, ChinaSchool of Pharmacy, Macau University of Science and Technology, Taipa, ChinaSchool of Pharmacy, Macau University of Science and Technology, Taipa, ChinaGuangzhou Municipal and Guangdong Provincial Key Laboratory of Molecular Target & Clinical Pharmacology, The NMPA and State Key Laboratory of Respiratory Disease, School of Pharmaceutical Sciences, Guangzhou Medical University, Guangzhou, ChinaGuangzhou Municipal and Guangdong Provincial Key Laboratory of Molecular Target & Clinical Pharmacology, The NMPA and State Key Laboratory of Respiratory Disease, School of Pharmaceutical Sciences, Guangzhou Medical University, Guangzhou, ChinaGuangzhou Municipal and Guangdong Provincial Key Laboratory of Molecular Target & Clinical Pharmacology, The NMPA and State Key Laboratory of Respiratory Disease, School of Pharmaceutical Sciences, Guangzhou Medical University, Guangzhou, ChinaEpigenetic changes have been associated with several cardiovascular diseases. In recent years, epigenetic inheritance based on spatial changes has gradually attracted attention. Alterations in three-dimensional chromatin structures have been shown to regulate gene expression and influence disease onset and progression. High-throughput Chromosome Conformation Capture (Hi-C) is a powerful method to detect spatial chromatin conformation changes. Since its development, Hi-C technology has been widely adopted for discovering novel therapeutic targets in cardiovascular research. In this review, we summarize key targets identified by Hi-C in cardiovascular diseases and discuss their potential implications for epigenetic therapy.https://www.frontiersin.org/articles/10.3389/fgene.2025.1515010/fullcardiovascular systemepigeneticheart diseaseHi-Ctherapeutic targetsthree-dimensional structure |
| spellingShingle | Quan Zheng Ying Liu Ying Liu Minghao Guo Xin Zhang Qingbin Zhang Xi-Yong Yu Zhongxiao Lin Discovery of therapeutic targets in cardiovascular diseases using high-throughput chromosome conformation capture (Hi-C) Frontiers in Genetics cardiovascular system epigenetic heart disease Hi-C therapeutic targets three-dimensional structure |
| title | Discovery of therapeutic targets in cardiovascular diseases using high-throughput chromosome conformation capture (Hi-C) |
| title_full | Discovery of therapeutic targets in cardiovascular diseases using high-throughput chromosome conformation capture (Hi-C) |
| title_fullStr | Discovery of therapeutic targets in cardiovascular diseases using high-throughput chromosome conformation capture (Hi-C) |
| title_full_unstemmed | Discovery of therapeutic targets in cardiovascular diseases using high-throughput chromosome conformation capture (Hi-C) |
| title_short | Discovery of therapeutic targets in cardiovascular diseases using high-throughput chromosome conformation capture (Hi-C) |
| title_sort | discovery of therapeutic targets in cardiovascular diseases using high throughput chromosome conformation capture hi c |
| topic | cardiovascular system epigenetic heart disease Hi-C therapeutic targets three-dimensional structure |
| url | https://www.frontiersin.org/articles/10.3389/fgene.2025.1515010/full |
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