Effect of Bacillus coagulans BC99 supplementation on body weight and gut microbiota in overweight and obese individual: a randomized, double-blind, placebo-controlled study
IntroductionProbiotic supplementation is a safe and effective way to reduce overweight and obesity by regulating the gut microbiota. The Bacillus coagulans strain BC99 is derived from humans and has various probiotic-related, acid resistance, bile salt resistance, and adhesion-related domains in the...
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Frontiers Media S.A.
2025-05-01
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| Series: | Frontiers in Nutrition |
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| Online Access: | https://www.frontiersin.org/articles/10.3389/fnut.2025.1542145/full |
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| author | Rui Wang Rui Wang Rui Wang Rui Wang Guoming Zhang Guoming Zhang Guoming Zhang Guoming Zhang Xiaoya Wang Xiaoya Wang Xiaoya Wang Xiaoya Wang Zefeng Xing Zefeng Xing Zefeng Xing Zefeng Xing Zhen Li Zhen Li Zhen Li Zhen Li Lixiang Li Lixiang Li Lixiang Li Lixiang Li |
| author_facet | Rui Wang Rui Wang Rui Wang Rui Wang Guoming Zhang Guoming Zhang Guoming Zhang Guoming Zhang Xiaoya Wang Xiaoya Wang Xiaoya Wang Xiaoya Wang Zefeng Xing Zefeng Xing Zefeng Xing Zefeng Xing Zhen Li Zhen Li Zhen Li Zhen Li Lixiang Li Lixiang Li Lixiang Li Lixiang Li |
| author_sort | Rui Wang |
| collection | DOAJ |
| description | IntroductionProbiotic supplementation is a safe and effective way to reduce overweight and obesity by regulating the gut microbiota. The Bacillus coagulans strain BC99 is derived from humans and has various probiotic-related, acid resistance, bile salt resistance, and adhesion-related domains in the genome. This study aimed to assess the effects of BC99 on the gut microbiota, body weight and lipid profiles of overweight and obese individuals.MethodsA total of 66 adult individuals were randomly assigned to a probiotic group (supplemented with 5 × 109 colony-forming units of BC99 per day along with 3 g of maltodextrin) and placebo group (supplemented with 3 g of maltodextrin daily) in a 1:1 ratio.ResultsAfter 8 weeks of oral administration, BC99 intervention significantly decreased the body weight of overweight individual (P < 0.01). Weight loss was significantly greater in the probiotic group than in the placebo group (P < 0.05). No significant differences were observed in lipid profiles between two groups. The microbiota analysis revealed that BC99 intervention significantly improved the β-diversity at week 4. The genus Parabacteroides was negatively correlated with body weight and was found to be enriched in the BC99 group.DiscussionThese findings suggest that B. coagulans strain BC99 could be a beneficial candidate for modulating the gut microbiota and improve body weight management for overweight individuals.Clinical trial registrationClinicalTrials.gov, identifier NCT06077383. |
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| language | English |
| publishDate | 2025-05-01 |
| publisher | Frontiers Media S.A. |
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| series | Frontiers in Nutrition |
| spelling | doaj-art-9e9eb0e6ce9f420188492e37fa5a9da72025-08-20T02:28:28ZengFrontiers Media S.A.Frontiers in Nutrition2296-861X2025-05-011210.3389/fnut.2025.15421451542145Effect of Bacillus coagulans BC99 supplementation on body weight and gut microbiota in overweight and obese individual: a randomized, double-blind, placebo-controlled studyRui Wang0Rui Wang1Rui Wang2Rui Wang3Guoming Zhang4Guoming Zhang5Guoming Zhang6Guoming Zhang7Xiaoya Wang8Xiaoya Wang9Xiaoya Wang10Xiaoya Wang11Zefeng Xing12Zefeng Xing13Zefeng Xing14Zefeng Xing15Zhen Li16Zhen Li17Zhen Li18Zhen Li19Lixiang Li20Lixiang Li21Lixiang Li22Lixiang Li23Department of Gastroenterology, Qilu Hospital of Shandong University, Jinan, Shandong, ChinaShandong Provincial Clinical Research Center for Digestive Disease, Jinan, Shandong, ChinaLaboratory of Translational Gastroenterology, Qilu Hospital of Shandong University, Jinan, Shandong, ChinaRobot Engineering Laboratory for Precise Diagnosis and Therapy of GI Tumor, Qilu Hospital of Shandong University, Jinan, Shandong, ChinaDepartment of Gastroenterology, Qilu Hospital of Shandong University, Jinan, Shandong, ChinaShandong Provincial Clinical Research Center for Digestive Disease, Jinan, Shandong, ChinaLaboratory of Translational Gastroenterology, Qilu Hospital of Shandong University, Jinan, Shandong, ChinaRobot Engineering Laboratory for Precise Diagnosis and Therapy of GI Tumor, Qilu Hospital of Shandong University, Jinan, Shandong, ChinaDepartment of Gastroenterology, Qilu Hospital of Shandong University, Jinan, Shandong, ChinaShandong Provincial Clinical Research Center for Digestive Disease, Jinan, Shandong, ChinaLaboratory of Translational Gastroenterology, Qilu Hospital of Shandong University, Jinan, Shandong, ChinaRobot Engineering Laboratory for Precise Diagnosis and Therapy of GI Tumor, Qilu Hospital of Shandong University, Jinan, Shandong, ChinaDepartment of Gastroenterology, Qilu Hospital of Shandong University, Jinan, Shandong, ChinaShandong Provincial Clinical Research Center for Digestive Disease, Jinan, Shandong, ChinaLaboratory of Translational Gastroenterology, Qilu Hospital of Shandong University, Jinan, Shandong, ChinaRobot Engineering Laboratory for Precise Diagnosis and Therapy of GI Tumor, Qilu Hospital of Shandong University, Jinan, Shandong, ChinaDepartment of Gastroenterology, Qilu Hospital of Shandong University, Jinan, Shandong, ChinaShandong Provincial Clinical Research Center for Digestive Disease, Jinan, Shandong, ChinaLaboratory of Translational Gastroenterology, Qilu Hospital of Shandong University, Jinan, Shandong, ChinaRobot Engineering Laboratory for Precise Diagnosis and Therapy of GI Tumor, Qilu Hospital of Shandong University, Jinan, Shandong, ChinaDepartment of Gastroenterology, Qilu Hospital of Shandong University, Jinan, Shandong, ChinaShandong Provincial Clinical Research Center for Digestive Disease, Jinan, Shandong, ChinaLaboratory of Translational Gastroenterology, Qilu Hospital of Shandong University, Jinan, Shandong, ChinaRobot Engineering Laboratory for Precise Diagnosis and Therapy of GI Tumor, Qilu Hospital of Shandong University, Jinan, Shandong, ChinaIntroductionProbiotic supplementation is a safe and effective way to reduce overweight and obesity by regulating the gut microbiota. The Bacillus coagulans strain BC99 is derived from humans and has various probiotic-related, acid resistance, bile salt resistance, and adhesion-related domains in the genome. This study aimed to assess the effects of BC99 on the gut microbiota, body weight and lipid profiles of overweight and obese individuals.MethodsA total of 66 adult individuals were randomly assigned to a probiotic group (supplemented with 5 × 109 colony-forming units of BC99 per day along with 3 g of maltodextrin) and placebo group (supplemented with 3 g of maltodextrin daily) in a 1:1 ratio.ResultsAfter 8 weeks of oral administration, BC99 intervention significantly decreased the body weight of overweight individual (P < 0.01). Weight loss was significantly greater in the probiotic group than in the placebo group (P < 0.05). No significant differences were observed in lipid profiles between two groups. The microbiota analysis revealed that BC99 intervention significantly improved the β-diversity at week 4. The genus Parabacteroides was negatively correlated with body weight and was found to be enriched in the BC99 group.DiscussionThese findings suggest that B. coagulans strain BC99 could be a beneficial candidate for modulating the gut microbiota and improve body weight management for overweight individuals.Clinical trial registrationClinicalTrials.gov, identifier NCT06077383.https://www.frontiersin.org/articles/10.3389/fnut.2025.1542145/fullB. coagulansgut microbiotaoverweightobeseprobiotics |
| spellingShingle | Rui Wang Rui Wang Rui Wang Rui Wang Guoming Zhang Guoming Zhang Guoming Zhang Guoming Zhang Xiaoya Wang Xiaoya Wang Xiaoya Wang Xiaoya Wang Zefeng Xing Zefeng Xing Zefeng Xing Zefeng Xing Zhen Li Zhen Li Zhen Li Zhen Li Lixiang Li Lixiang Li Lixiang Li Lixiang Li Effect of Bacillus coagulans BC99 supplementation on body weight and gut microbiota in overweight and obese individual: a randomized, double-blind, placebo-controlled study Frontiers in Nutrition B. coagulans gut microbiota overweight obese probiotics |
| title | Effect of Bacillus coagulans BC99 supplementation on body weight and gut microbiota in overweight and obese individual: a randomized, double-blind, placebo-controlled study |
| title_full | Effect of Bacillus coagulans BC99 supplementation on body weight and gut microbiota in overweight and obese individual: a randomized, double-blind, placebo-controlled study |
| title_fullStr | Effect of Bacillus coagulans BC99 supplementation on body weight and gut microbiota in overweight and obese individual: a randomized, double-blind, placebo-controlled study |
| title_full_unstemmed | Effect of Bacillus coagulans BC99 supplementation on body weight and gut microbiota in overweight and obese individual: a randomized, double-blind, placebo-controlled study |
| title_short | Effect of Bacillus coagulans BC99 supplementation on body weight and gut microbiota in overweight and obese individual: a randomized, double-blind, placebo-controlled study |
| title_sort | effect of bacillus coagulans bc99 supplementation on body weight and gut microbiota in overweight and obese individual a randomized double blind placebo controlled study |
| topic | B. coagulans gut microbiota overweight obese probiotics |
| url | https://www.frontiersin.org/articles/10.3389/fnut.2025.1542145/full |
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