Metal-Based Drug–DNA Interactions and Analytical Determination Methods
DNA structure has many potential places where endogenous compounds and xenobiotics can bind. Therefore, xenobiotics bind along the sites of the nucleic acid with the aim of changing its structure, its genetic message, and, implicitly, its functions. Currently, there are several mechanisms known to b...
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| Format: | Article |
| Language: | English |
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MDPI AG
2024-09-01
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| Series: | Molecules |
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| Online Access: | https://www.mdpi.com/1420-3049/29/18/4361 |
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| author | Adriana Corina Hangan Luminița Simona Oprean Lucia Dican Lucia Maria Procopciuc Bogdan Sevastre Roxana Liana Lucaciu |
| author_facet | Adriana Corina Hangan Luminița Simona Oprean Lucia Dican Lucia Maria Procopciuc Bogdan Sevastre Roxana Liana Lucaciu |
| author_sort | Adriana Corina Hangan |
| collection | DOAJ |
| description | DNA structure has many potential places where endogenous compounds and xenobiotics can bind. Therefore, xenobiotics bind along the sites of the nucleic acid with the aim of changing its structure, its genetic message, and, implicitly, its functions. Currently, there are several mechanisms known to be involved in DNA binding. These mechanisms are covalent and non-covalent interactions. The covalent interaction or metal base coordination is an irreversible binding and it is represented by an intra-/interstrand cross-link. The non-covalent interaction is generally a reversible binding and it is represented by intercalation between DNA base pairs, insertion, major and/or minor groove binding, and electrostatic interactions with the sugar phosphate DNA backbone. In the present review, we focus on the types of DNA–metal complex interactions (including some representative examples) and on presenting the methods currently used to study them. |
| format | Article |
| id | doaj-art-9e9cde924c6645f48445b8a3597db481 |
| institution | OA Journals |
| issn | 1420-3049 |
| language | English |
| publishDate | 2024-09-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Molecules |
| spelling | doaj-art-9e9cde924c6645f48445b8a3597db4812025-08-20T01:55:42ZengMDPI AGMolecules1420-30492024-09-012918436110.3390/molecules29184361Metal-Based Drug–DNA Interactions and Analytical Determination MethodsAdriana Corina Hangan0Luminița Simona Oprean1Lucia Dican2Lucia Maria Procopciuc3Bogdan Sevastre4Roxana Liana Lucaciu5Department of Inorganic Chemistry, Faculty of Pharmacy, “Iuliu-Hațieganu” University of Medicine and Pharmacy, 400012 Cluj-Napoca, RomaniaDepartment of Inorganic Chemistry, Faculty of Pharmacy, “Iuliu-Hațieganu” University of Medicine and Pharmacy, 400012 Cluj-Napoca, RomaniaDepartment of Medical Biochemistry, Faculty of Medicine, “Iuliu-Hațieganu” University of Medicine and Pharmacy, 400012 Cluj-Napoca, RomaniaDepartment of Medical Biochemistry, Faculty of Medicine, “Iuliu-Hațieganu” University of Medicine and Pharmacy, 400012 Cluj-Napoca, RomaniaClinic Department, Faculty of Veterinary Medicine, University of Agricultural Science and Veterinary Medicine, 400372 Cluj-Napoca, RomaniaDepartment of Pharmaceutical Biochemistry and Clinical Laboratory, Faculty of Pharmacy, “Iuliu-Hațieganu” University of Medicine and Pharmacy, 400012 Cluj-Napoca, RomaniaDNA structure has many potential places where endogenous compounds and xenobiotics can bind. Therefore, xenobiotics bind along the sites of the nucleic acid with the aim of changing its structure, its genetic message, and, implicitly, its functions. Currently, there are several mechanisms known to be involved in DNA binding. These mechanisms are covalent and non-covalent interactions. The covalent interaction or metal base coordination is an irreversible binding and it is represented by an intra-/interstrand cross-link. The non-covalent interaction is generally a reversible binding and it is represented by intercalation between DNA base pairs, insertion, major and/or minor groove binding, and electrostatic interactions with the sugar phosphate DNA backbone. In the present review, we focus on the types of DNA–metal complex interactions (including some representative examples) and on presenting the methods currently used to study them.https://www.mdpi.com/1420-3049/29/18/4361DNADNA interactionsmetal complexesbioinorganic chemistry |
| spellingShingle | Adriana Corina Hangan Luminița Simona Oprean Lucia Dican Lucia Maria Procopciuc Bogdan Sevastre Roxana Liana Lucaciu Metal-Based Drug–DNA Interactions and Analytical Determination Methods Molecules DNA DNA interactions metal complexes bioinorganic chemistry |
| title | Metal-Based Drug–DNA Interactions and Analytical Determination Methods |
| title_full | Metal-Based Drug–DNA Interactions and Analytical Determination Methods |
| title_fullStr | Metal-Based Drug–DNA Interactions and Analytical Determination Methods |
| title_full_unstemmed | Metal-Based Drug–DNA Interactions and Analytical Determination Methods |
| title_short | Metal-Based Drug–DNA Interactions and Analytical Determination Methods |
| title_sort | metal based drug dna interactions and analytical determination methods |
| topic | DNA DNA interactions metal complexes bioinorganic chemistry |
| url | https://www.mdpi.com/1420-3049/29/18/4361 |
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