miR-125b expression in breast cancer: Insights into subtypes and demographic factors at Hospital Canselor Tuanku Muhriz (HCTM)
Breast cancer (BC), the most prevalent and fatal female neoplasm worldwide, including in Malaysia, is a heterogeneous disease classified into subtypes based on hormone receptor status, including luminal A, luminal B, HER2-enriched and triple-negative. The heterogeneity of BC poses challenges for acc...
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| Main Authors: | , , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
Biome Scientia
2025-05-01
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| Series: | Life Sciences, Medicine and Biomedicine |
| Subjects: | |
| Online Access: | https://biomescientia.com/index.php/lsmb/article/view/171 |
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| Summary: | Breast cancer (BC), the most prevalent and fatal female neoplasm worldwide, including in Malaysia, is a heterogeneous disease classified into subtypes based on hormone receptor status, including luminal A, luminal B, HER2-enriched and triple-negative. The heterogeneity of BC poses challenges for accurate diagnosis and treatment, necessitating novel biomarkers to aid cancer screening, diagnosis and therapy. MicroRNAs (miRNAs), which regulate gene expression, are often dysregulated in cancer. Specifically, miR-125b has been linked to mitochondrial dysfunction and chemoresistance, supporting its potential as a biomarker for BC, particularly as a predictive biomarker. This study aims to investigate the associations between miR-125b expression patterns in different BC subtypes and demographic profiles at Hospital Canselor Tuanku Muhriz, Universiti Kebangsaan Malaysia (HCTM). miR-125b expression was analysed in 18 formalin-fixed paraffin-embedded (FFPE) BC tissue samples and two control tissues by quantitative polymerase chain reaction (qPCR). Among 241 BC cases reported at HCTM in 2023, patients were predominantly Malay, aged 50 and above, with luminal A being the most common subtype, followed by triple-negative, luminal B and HER2-enriched. miR-125b expression was consistently downregulated in BC tissues compared to controls, although this difference was not statistically significant (p = 0.263). Trends of downregulation were observed across all subtypes and demographic groups, with no significant differences by age (p = 1.000), ethnicity (p = 0.546) or BC subtypes (p = 0.701). The consistent downregulation of miR-125b aligns with previous studies and highlights its biomarker potential for BC diagnosis and prognosis. Further research with a larger cohort is needed to validate these findings and explore the potential of miR-125b as a diagnostic, prognostic or predictive biomarker in BC. |
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| ISSN: | 2600-7207 |