A novel anti-inflammatory activity of lysozyme: modulation of serum complement activation
Lysozyme is an ubiquitous enzyme found in most biological secretions and leukocytes. This study was aimed at investigating its interaction with other inflammatory mediators on mucosa surfaces, particularly the complement system. Lysozyme has been shown in our present study, to inhibit the haemolytic...
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| Format: | Article |
| Language: | English |
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Wiley
1998-01-01
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| Series: | Mediators of Inflammation |
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| Online Access: | http://dx.doi.org/10.1080/09629359890893 |
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| _version_ | 1832565803446173696 |
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| author | M. O. Ogundele |
| author_facet | M. O. Ogundele |
| author_sort | M. O. Ogundele |
| collection | DOAJ |
| description | Lysozyme is an ubiquitous enzyme found in most biological secretions and leukocytes. This study was aimed at investigating its interaction with other inflammatory mediators on mucosa surfaces, particularly the complement system. Lysozyme has been shown in our present study, to inhibit the haemolytic activity of serum complement in a dose-dependent fashion, when tested within the levels present in normal and inflamed breast-milk samples, and other mucosal secretions. This represents a new antiinflammatory action of lysozym e in relation to the serum complement, and the exact mode of the interaction need further studies. |
| format | Article |
| id | doaj-art-9e9ac78907bf45ed93241ee5ee366831 |
| institution | Kabale University |
| issn | 0962-9351 1466-1861 |
| language | English |
| publishDate | 1998-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Mediators of Inflammation |
| spelling | doaj-art-9e9ac78907bf45ed93241ee5ee3668312025-02-03T01:06:41ZengWileyMediators of Inflammation0962-93511466-18611998-01-017536336510.1080/09629359890893A novel anti-inflammatory activity of lysozyme: modulation of serum complement activationM. O. Ogundele0Department of Immunology, Georg-August University, Kreuzbergring 57, Göttingen D-37075, GermanyLysozyme is an ubiquitous enzyme found in most biological secretions and leukocytes. This study was aimed at investigating its interaction with other inflammatory mediators on mucosa surfaces, particularly the complement system. Lysozyme has been shown in our present study, to inhibit the haemolytic activity of serum complement in a dose-dependent fashion, when tested within the levels present in normal and inflamed breast-milk samples, and other mucosal secretions. This represents a new antiinflammatory action of lysozym e in relation to the serum complement, and the exact mode of the interaction need further studies.http://dx.doi.org/10.1080/09629359890893Human lysozymeComplement systemInflammation. |
| spellingShingle | M. O. Ogundele A novel anti-inflammatory activity of lysozyme: modulation of serum complement activation Mediators of Inflammation Human lysozyme Complement system Inflammation. |
| title | A novel anti-inflammatory activity of lysozyme: modulation of serum
complement activation |
| title_full | A novel anti-inflammatory activity of lysozyme: modulation of serum
complement activation |
| title_fullStr | A novel anti-inflammatory activity of lysozyme: modulation of serum
complement activation |
| title_full_unstemmed | A novel anti-inflammatory activity of lysozyme: modulation of serum
complement activation |
| title_short | A novel anti-inflammatory activity of lysozyme: modulation of serum
complement activation |
| title_sort | novel anti inflammatory activity of lysozyme modulation of serum complement activation |
| topic | Human lysozyme Complement system Inflammation. |
| url | http://dx.doi.org/10.1080/09629359890893 |
| work_keys_str_mv | AT moogundele anovelantiinflammatoryactivityoflysozymemodulationofserumcomplementactivation AT moogundele novelantiinflammatoryactivityoflysozymemodulationofserumcomplementactivation |