Molecular characterization of pregnancy-associated breast cancer and insights on timing from GEICAM-EMBARCAM study
Abstract Pregnancy-associated breast cancer (PABC), diagnosed during or shortly after pregnancy, is a challenging entity with an aggressive biology and poor prognosis. This study analyzed the clinicopathological characteristics and gene expression profile of 33 PABC and 26 non-PABC patients using th...
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| Format: | Article |
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Nature Portfolio
2025-02-01
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| Series: | npj Breast Cancer |
| Online Access: | https://doi.org/10.1038/s41523-025-00718-x |
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| author | Regina Peña-Enríquez Begoña Bermejo Marina Pollán Alejandra Díaz-Chacón Yolanda Jerez Gilarranz José J Ponce Lorenzo Antonio Fernández Aramburo Blanca Cantos Sánchez de Ibargüen Ana Santaballa Bertrán Elena Galve-Calvo Álvaro Jiménez-Arranz Yolanda Fernández María Eva Pérez Susana De La Cruz Antonio Anton-Torres Fernando Moreno María Jesús Vidal-Losada María Helena López-Ceballos Isabel Blancas María José Echarri Raúl Rincón Rosalía Caballero Ángel Guerrero-Zotano Silvia Guil-Luna Juan de la Haba-Rodríguez |
| author_facet | Regina Peña-Enríquez Begoña Bermejo Marina Pollán Alejandra Díaz-Chacón Yolanda Jerez Gilarranz José J Ponce Lorenzo Antonio Fernández Aramburo Blanca Cantos Sánchez de Ibargüen Ana Santaballa Bertrán Elena Galve-Calvo Álvaro Jiménez-Arranz Yolanda Fernández María Eva Pérez Susana De La Cruz Antonio Anton-Torres Fernando Moreno María Jesús Vidal-Losada María Helena López-Ceballos Isabel Blancas María José Echarri Raúl Rincón Rosalía Caballero Ángel Guerrero-Zotano Silvia Guil-Luna Juan de la Haba-Rodríguez |
| author_sort | Regina Peña-Enríquez |
| collection | DOAJ |
| description | Abstract Pregnancy-associated breast cancer (PABC), diagnosed during or shortly after pregnancy, is a challenging entity with an aggressive biology and poor prognosis. This study analyzed the clinicopathological characteristics and gene expression profile of 33 PABC and 26 non-PABC patients using the nCounter BC360 Panel (NanoString). Notably, PABC showed a higher prevalence of basal-like tumors than non-PABC (48.48% vs 15.38%, p = 0.012) and displayed 73 differentially expressed genes (e.g., DEPDC1, CCNA2, PSAT1, CDKN3, and FAM83D), enriched in DNA repair and cell proliferation pathways. Through the PPI network, we also identified a cluster of cell-cycle regulation genes like MYC, FOXM1, or PTEN. Interestingly, differences emerged when comparing patients diagnosed during gestation (PABC-GS) and the postpartum period (PABC-PP), with PABC-PP showing increased expression of immune-related genes, including PD-1, and greater immune cell infiltration (Tregs, macrophages, neutrophils, B-cells). These findings suggest an enhanced proliferative capacity and impaired DNA repair in PABC, and underscore the role of immune infiltration in postpartum cases; providing insights into its aggressive nature and potential targets. |
| format | Article |
| id | doaj-art-9e990b6fd4f642cfae05e18b833d62c6 |
| institution | Kabale University |
| issn | 2374-4677 |
| language | English |
| publishDate | 2025-02-01 |
| publisher | Nature Portfolio |
| record_format | Article |
| series | npj Breast Cancer |
| spelling | doaj-art-9e990b6fd4f642cfae05e18b833d62c62025-02-09T12:48:27ZengNature Portfolionpj Breast Cancer2374-46772025-02-0111111610.1038/s41523-025-00718-xMolecular characterization of pregnancy-associated breast cancer and insights on timing from GEICAM-EMBARCAM studyRegina Peña-Enríquez0Begoña Bermejo1Marina Pollán2Alejandra Díaz-Chacón3Yolanda Jerez Gilarranz4José J Ponce Lorenzo5Antonio Fernández Aramburo6Blanca Cantos Sánchez de Ibargüen7Ana Santaballa Bertrán8Elena Galve-Calvo9Álvaro Jiménez-Arranz10Yolanda Fernández11María Eva Pérez12Susana De La Cruz13Antonio Anton-Torres14Fernando Moreno15María Jesús Vidal-Losada16María Helena López-Ceballos17Isabel Blancas18María José Echarri19Raúl Rincón20Rosalía Caballero21Ángel Guerrero-Zotano22Silvia Guil-Luna23Juan de la Haba-Rodríguez24Instituto Maimónides de Investigación Biomédica de Córdoba (IMIBIC)-Hospital Universitario Reina Sofía, Universidad de CórdobaGEICAM, Spanish Breast Cancer GroupGEICAM, Spanish Breast Cancer GroupInstituto Maimónides de Investigación Biomédica de Córdoba (IMIBIC)-Hospital Universitario Reina Sofía, Universidad de CórdobaGEICAM, Spanish Breast Cancer GroupGEICAM, Spanish Breast Cancer GroupGEICAM, Spanish Breast Cancer GroupGEICAM, Spanish Breast Cancer GroupGEICAM, Spanish Breast Cancer GroupGEICAM, Spanish Breast Cancer GroupInstituto Maimónides de Investigación Biomédica de Córdoba (IMIBIC)-Hospital Universitario Reina Sofía, Universidad de CórdobaGEICAM, Spanish Breast Cancer GroupGEICAM, Spanish Breast Cancer GroupGEICAM, Spanish Breast Cancer GroupGEICAM, Spanish Breast Cancer GroupGEICAM, Spanish Breast Cancer GroupGEICAM, Spanish Breast Cancer GroupGEICAM, Spanish Breast Cancer GroupGEICAM, Spanish Breast Cancer GroupGEICAM, Spanish Breast Cancer GroupGEICAM, Spanish Breast Cancer GroupGEICAM, Spanish Breast Cancer GroupGEICAM, Spanish Breast Cancer GroupInstituto Maimónides de Investigación Biomédica de Córdoba (IMIBIC)-Hospital Universitario Reina Sofía, Universidad de CórdobaInstituto Maimónides de Investigación Biomédica de Córdoba (IMIBIC)-Hospital Universitario Reina Sofía, Universidad de CórdobaAbstract Pregnancy-associated breast cancer (PABC), diagnosed during or shortly after pregnancy, is a challenging entity with an aggressive biology and poor prognosis. This study analyzed the clinicopathological characteristics and gene expression profile of 33 PABC and 26 non-PABC patients using the nCounter BC360 Panel (NanoString). Notably, PABC showed a higher prevalence of basal-like tumors than non-PABC (48.48% vs 15.38%, p = 0.012) and displayed 73 differentially expressed genes (e.g., DEPDC1, CCNA2, PSAT1, CDKN3, and FAM83D), enriched in DNA repair and cell proliferation pathways. Through the PPI network, we also identified a cluster of cell-cycle regulation genes like MYC, FOXM1, or PTEN. Interestingly, differences emerged when comparing patients diagnosed during gestation (PABC-GS) and the postpartum period (PABC-PP), with PABC-PP showing increased expression of immune-related genes, including PD-1, and greater immune cell infiltration (Tregs, macrophages, neutrophils, B-cells). These findings suggest an enhanced proliferative capacity and impaired DNA repair in PABC, and underscore the role of immune infiltration in postpartum cases; providing insights into its aggressive nature and potential targets.https://doi.org/10.1038/s41523-025-00718-x |
| spellingShingle | Regina Peña-Enríquez Begoña Bermejo Marina Pollán Alejandra Díaz-Chacón Yolanda Jerez Gilarranz José J Ponce Lorenzo Antonio Fernández Aramburo Blanca Cantos Sánchez de Ibargüen Ana Santaballa Bertrán Elena Galve-Calvo Álvaro Jiménez-Arranz Yolanda Fernández María Eva Pérez Susana De La Cruz Antonio Anton-Torres Fernando Moreno María Jesús Vidal-Losada María Helena López-Ceballos Isabel Blancas María José Echarri Raúl Rincón Rosalía Caballero Ángel Guerrero-Zotano Silvia Guil-Luna Juan de la Haba-Rodríguez Molecular characterization of pregnancy-associated breast cancer and insights on timing from GEICAM-EMBARCAM study npj Breast Cancer |
| title | Molecular characterization of pregnancy-associated breast cancer and insights on timing from GEICAM-EMBARCAM study |
| title_full | Molecular characterization of pregnancy-associated breast cancer and insights on timing from GEICAM-EMBARCAM study |
| title_fullStr | Molecular characterization of pregnancy-associated breast cancer and insights on timing from GEICAM-EMBARCAM study |
| title_full_unstemmed | Molecular characterization of pregnancy-associated breast cancer and insights on timing from GEICAM-EMBARCAM study |
| title_short | Molecular characterization of pregnancy-associated breast cancer and insights on timing from GEICAM-EMBARCAM study |
| title_sort | molecular characterization of pregnancy associated breast cancer and insights on timing from geicam embarcam study |
| url | https://doi.org/10.1038/s41523-025-00718-x |
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