TFAP4 exacerbates pathological cardiac fibrosis by modulating mechanotransduction

TFAP4 exacerbates pathological cardiac fibrosis by modulating mechanotransduction

Cardiac fibroblast (CF) differentiation into myofibroblasts is a crucial driver of cardiac fibrosis, leading to extensive extracellular matrix (ECM) deposition that increases myocardial stiffness and eventually impairs heart function. Mechanotransduction has merged as a key regulator of CF activatio...

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Bibliographic Details
Main Authors: Jie Liu, Jingjing Feng, Jingxuan Zhao, Xiangjie Kong, Zhangyi Yu, Yuanru Huang, Zechun He, Mengxin Liu, Zheng Liu, Zhibing Lu, Li Wang
Format: Article
Language:English
Published: Elsevier 2025-08-01
Series:Cell Insight
Subjects:
Cardiac fibrosis
Fibroblast activation
Mechanotransduction
TFAP4
Online Access:http://www.sciencedirect.com/science/article/pii/S2772892725000306
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