The microbiota, the malarial parasite, and the mice—a three-sided relationship
In recent years, the role of gut microbiota in modulating malaria susceptibility and infection progression has emerged as a pivotal focus in interdisciplinary research. While existing reviews have delineated mechanisms by which mosquito-associated gut microbiota regulate Plasmodium development, a sy...
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Frontiers Media S.A.
2025-06-01
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| Series: | Frontiers in Microbiology |
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| Online Access: | https://www.frontiersin.org/articles/10.3389/fmicb.2025.1615846/full |
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| author | Shanli He Yanwei Qi |
| author_facet | Shanli He Yanwei Qi |
| author_sort | Shanli He |
| collection | DOAJ |
| description | In recent years, the role of gut microbiota in modulating malaria susceptibility and infection progression has emerged as a pivotal focus in interdisciplinary research. While existing reviews have delineated mechanisms by which mosquito-associated gut microbiota regulate Plasmodium development, a systematic synthesis of the tripartite interplay among host gut microbiota, Plasmodium and host immunometabolic networks remains absent. Compared with previous studies predominantly focusing on single species or unitary mechanisms, this review fills the gap in cross-species integrated analysis of host-microbiota-pathogen interactions. By consolidating metagenomic, metabolomic, and immunological data, this review transitions from unitary mechanistic explanations to multi-omics-driven systematic analyses, demonstrating that murine microbiota suppresses Plasmodium proliferation through adaptive immune activation and metabolic product regulation. Meanwhile, Plasmodium infection induces decreased microbial diversity and functional pathway deviation in murine microbiota, exacerbating host immunometabolic imbalance. These advancements not only elucidate core biological principles governing “microbiota-host-pathogen” interactions but also transcend traditional pathogen-centric perspectives by pioneering precise intervention strategies based on microbiota homeostasis restoration. This provides theoretical foundation for developing microbiome-targeted precision prevention approaches, which will continue to make substantial contributions to malaria research. |
| format | Article |
| id | doaj-art-9e90ffbf96b342ee9a03edafb16a3ab9 |
| institution | DOAJ |
| issn | 1664-302X |
| language | English |
| publishDate | 2025-06-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Microbiology |
| spelling | doaj-art-9e90ffbf96b342ee9a03edafb16a3ab92025-08-20T03:07:21ZengFrontiers Media S.A.Frontiers in Microbiology1664-302X2025-06-011610.3389/fmicb.2025.16158461615846The microbiota, the malarial parasite, and the mice—a three-sided relationshipShanli He0Yanwei Qi1The Second School of Clinical Medicine, Guangzhou Medical University, Guangzhou, ChinaDepartment of Pathogenic Biology and Immunology, School of Basic Medical Sciences, Guangzhou Medical University, Guangzhou, ChinaIn recent years, the role of gut microbiota in modulating malaria susceptibility and infection progression has emerged as a pivotal focus in interdisciplinary research. While existing reviews have delineated mechanisms by which mosquito-associated gut microbiota regulate Plasmodium development, a systematic synthesis of the tripartite interplay among host gut microbiota, Plasmodium and host immunometabolic networks remains absent. Compared with previous studies predominantly focusing on single species or unitary mechanisms, this review fills the gap in cross-species integrated analysis of host-microbiota-pathogen interactions. By consolidating metagenomic, metabolomic, and immunological data, this review transitions from unitary mechanistic explanations to multi-omics-driven systematic analyses, demonstrating that murine microbiota suppresses Plasmodium proliferation through adaptive immune activation and metabolic product regulation. Meanwhile, Plasmodium infection induces decreased microbial diversity and functional pathway deviation in murine microbiota, exacerbating host immunometabolic imbalance. These advancements not only elucidate core biological principles governing “microbiota-host-pathogen” interactions but also transcend traditional pathogen-centric perspectives by pioneering precise intervention strategies based on microbiota homeostasis restoration. This provides theoretical foundation for developing microbiome-targeted precision prevention approaches, which will continue to make substantial contributions to malaria research.https://www.frontiersin.org/articles/10.3389/fmicb.2025.1615846/fullPlasmodiummalariagut microbiotamiceimmune responsemetabolic regulation |
| spellingShingle | Shanli He Yanwei Qi The microbiota, the malarial parasite, and the mice—a three-sided relationship Frontiers in Microbiology Plasmodium malaria gut microbiota mice immune response metabolic regulation |
| title | The microbiota, the malarial parasite, and the mice—a three-sided relationship |
| title_full | The microbiota, the malarial parasite, and the mice—a three-sided relationship |
| title_fullStr | The microbiota, the malarial parasite, and the mice—a three-sided relationship |
| title_full_unstemmed | The microbiota, the malarial parasite, and the mice—a three-sided relationship |
| title_short | The microbiota, the malarial parasite, and the mice—a three-sided relationship |
| title_sort | microbiota the malarial parasite and the mice a three sided relationship |
| topic | Plasmodium malaria gut microbiota mice immune response metabolic regulation |
| url | https://www.frontiersin.org/articles/10.3389/fmicb.2025.1615846/full |
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