Toward Full Autonomous Laboratory Instrumentation Control with Large Language Models
The control of complex laboratory instrumentation often requires significant programming expertise, creating a barrier for researchers lacking computational skills. This work explores the potential of large language models (LLMs), such as ChatGPT, to enable efficient programming and automation of sc...
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| Format: | Article |
| Language: | English |
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Wiley-VCH
2025-08-01
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| Series: | Small Structures |
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| Online Access: | https://doi.org/10.1002/sstr.202500173 |
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| author | Yong Xie Kexin He Andres Castellanos‐Gomez |
| author_facet | Yong Xie Kexin He Andres Castellanos‐Gomez |
| author_sort | Yong Xie |
| collection | DOAJ |
| description | The control of complex laboratory instrumentation often requires significant programming expertise, creating a barrier for researchers lacking computational skills. This work explores the potential of large language models (LLMs), such as ChatGPT, to enable efficient programming and automation of scientific equipment. Through a case study involving the implementation of a setup that can be used as a single‐pixel camera or a scanning photocurrent microscope, it is demonstrated how ChatGPT can facilitate the creation of custom scripts for instrumentation control, significantly reducing the technical barrier for experimental customization. Building on this capability, it is further illustrated how LLM‐assisted tools can be used to develop autonomous agents capable of independently operating laboratory instruments. This approach underscores the transformative role of LLM‐based tools in democratizing laboratory automation and accelerating scientific progress. |
| format | Article |
| id | doaj-art-9e8da26deac84b9a8680f1845af46bd1 |
| institution | Kabale University |
| issn | 2688-4062 |
| language | English |
| publishDate | 2025-08-01 |
| publisher | Wiley-VCH |
| record_format | Article |
| series | Small Structures |
| spelling | doaj-art-9e8da26deac84b9a8680f1845af46bd12025-08-20T03:59:25ZengWiley-VCHSmall Structures2688-40622025-08-0168n/an/a10.1002/sstr.202500173Toward Full Autonomous Laboratory Instrumentation Control with Large Language ModelsYong Xie0Kexin He1Andres Castellanos‐Gomez2Key Laboratory of Wide Band‐Gap Semiconductor Technology School of Advanced Materials and Nanotechnology Xidian University Xi'an 710071 ChinaKey Laboratory of Wide Band‐Gap Semiconductor Technology School of Advanced Materials and Nanotechnology Xidian University Xi'an 710071 China2D Foundry Research Group Instituto de Ciencia de Materiales de Madrid (ICMM‐CSIC) E‐28049 Madrid SpainThe control of complex laboratory instrumentation often requires significant programming expertise, creating a barrier for researchers lacking computational skills. This work explores the potential of large language models (LLMs), such as ChatGPT, to enable efficient programming and automation of scientific equipment. Through a case study involving the implementation of a setup that can be used as a single‐pixel camera or a scanning photocurrent microscope, it is demonstrated how ChatGPT can facilitate the creation of custom scripts for instrumentation control, significantly reducing the technical barrier for experimental customization. Building on this capability, it is further illustrated how LLM‐assisted tools can be used to develop autonomous agents capable of independently operating laboratory instruments. This approach underscores the transformative role of LLM‐based tools in democratizing laboratory automation and accelerating scientific progress.https://doi.org/10.1002/sstr.202500173ChatGPTinstrumentation controllaboratory automationlarge language modelsscanning photocurrent microscopy |
| spellingShingle | Yong Xie Kexin He Andres Castellanos‐Gomez Toward Full Autonomous Laboratory Instrumentation Control with Large Language Models Small Structures ChatGPT instrumentation control laboratory automation large language models scanning photocurrent microscopy |
| title | Toward Full Autonomous Laboratory Instrumentation Control with Large Language Models |
| title_full | Toward Full Autonomous Laboratory Instrumentation Control with Large Language Models |
| title_fullStr | Toward Full Autonomous Laboratory Instrumentation Control with Large Language Models |
| title_full_unstemmed | Toward Full Autonomous Laboratory Instrumentation Control with Large Language Models |
| title_short | Toward Full Autonomous Laboratory Instrumentation Control with Large Language Models |
| title_sort | toward full autonomous laboratory instrumentation control with large language models |
| topic | ChatGPT instrumentation control laboratory automation large language models scanning photocurrent microscopy |
| url | https://doi.org/10.1002/sstr.202500173 |
| work_keys_str_mv | AT yongxie towardfullautonomouslaboratoryinstrumentationcontrolwithlargelanguagemodels AT kexinhe towardfullautonomouslaboratoryinstrumentationcontrolwithlargelanguagemodels AT andrescastellanosgomez towardfullautonomouslaboratoryinstrumentationcontrolwithlargelanguagemodels |