Association of Long‐Term Exposure to PM2.5 Constituents and Green Space With Arthritis and Rheumatoid Arthritis
Abstract There is limited evidence regarding the effects of long‐term exposure to PM2.5 constituents on the risk of arthritis and rheumatoid arthritis, and the interaction between PM2.5 and green space remains unclear. This study examined the relationship between long‐term exposure to PM2.5 constitu...
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| Format: | Article |
| Language: | English |
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American Geophysical Union (AGU)
2024-11-01
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| Series: | GeoHealth |
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| Online Access: | https://doi.org/10.1029/2024GH001132 |
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| author | Yi‐Sheng He Yi‐Qing Xu Fan Cao Zhao‐Xing Gao Man Ge Tian He Peng Zhang Chan‐Na Zhao Peng Wang Zhiwei Xu Hai‐Feng Pan |
| author_facet | Yi‐Sheng He Yi‐Qing Xu Fan Cao Zhao‐Xing Gao Man Ge Tian He Peng Zhang Chan‐Na Zhao Peng Wang Zhiwei Xu Hai‐Feng Pan |
| author_sort | Yi‐Sheng He |
| collection | DOAJ |
| description | Abstract There is limited evidence regarding the effects of long‐term exposure to PM2.5 constituents on the risk of arthritis and rheumatoid arthritis, and the interaction between PM2.5 and green space remains unclear. This study examined the relationship between long‐term exposure to PM2.5 constituents and the risk of arthritis and rheumatoid arthritis, with the exposure period extending from recruitment until self‐reported outcomes, death, loss to follow‐up, or end of follow‐up. Additionally, the study assessed whether there was an interactive effect between PM2.5 and green space on these risks. We gathered cohort data on 18,649 individuals aged ≥45 years. We applied generalized linear mixed‐effects models to estimate the effects of PM2.5 constituents, NDVI, and their interaction on arthritis and rheumatoid arthritis. The quantile g‐computation and weighted quantile sum regression model were applied to estimate the combined effect of PM2.5 constituents. Our results showed that exposure to single and mixed PM2.5 constituents adversely affected arthritis and rheumatoid arthritis, and was mainly attributed to the black carbon component. We observed “U” or “J” shaped exposure‐response curves for the effects of PM2.5, OM, NO3− and NH4+ exposure on the development of arthritis/rheumatoid arthritis. Additionally, the odds ratio of arthritis for per interquartile range (IQR) increase in PM2.5 was 1.209 (95% CI:1.198, 1.221), per 0.1‐unit decrease in NDVI was 1.091 (95% CI:1.033, 1.151), and the interaction term was 1.005 (95% CI:1.002, 1.007). These findings flesh out the existing evidence for PM2.5 constituents, NDVI and arthritis, rheumatoid arthritis, but the underlying mechanisms still require further exploration. |
| format | Article |
| id | doaj-art-9e8a46ab6cd0457b8970c077adb409b0 |
| institution | OA Journals |
| issn | 2471-1403 |
| language | English |
| publishDate | 2024-11-01 |
| publisher | American Geophysical Union (AGU) |
| record_format | Article |
| series | GeoHealth |
| spelling | doaj-art-9e8a46ab6cd0457b8970c077adb409b02025-08-20T02:05:28ZengAmerican Geophysical Union (AGU)GeoHealth2471-14032024-11-01811n/an/a10.1029/2024GH001132Association of Long‐Term Exposure to PM2.5 Constituents and Green Space With Arthritis and Rheumatoid ArthritisYi‐Sheng He0Yi‐Qing Xu1Fan Cao2Zhao‐Xing Gao3Man Ge4Tian He5Peng Zhang6Chan‐Na Zhao7Peng Wang8Zhiwei Xu9Hai‐Feng Pan10Department of Epidemiology and Biostatistics School of Public Health Anhui Medical University Hefei ChinaDepartment of Epidemiology and Biostatistics School of Public Health Anhui Medical University Hefei ChinaBeijing Ophthalmology & Visual Sciences Key Laboratory Beijing Institute of Ophthalmology Beijing Tongren Eye Center Beijing Tongren Hospital Capital Medical University Beijing ChinaDepartment of Epidemiology and Biostatistics School of Public Health Anhui Medical University Hefei ChinaDepartment of Epidemiology and Biostatistics School of Public Health Anhui Medical University Hefei ChinaDepartment of Epidemiology and Biostatistics School of Public Health Anhui Medical University Hefei ChinaDepartment of Epidemiology and Biostatistics School of Public Health Anhui Medical University Hefei ChinaDepartment of Epidemiology and Biostatistics School of Public Health Anhui Medical University Hefei ChinaTeaching Center for Preventive Medicine School of Public Health Anhui Medical University Hefei ChinaSchool of Medicine and Dentistry Griffith University Gold Coast QLD AustraliaDepartment of Epidemiology and Biostatistics School of Public Health Anhui Medical University Hefei ChinaAbstract There is limited evidence regarding the effects of long‐term exposure to PM2.5 constituents on the risk of arthritis and rheumatoid arthritis, and the interaction between PM2.5 and green space remains unclear. This study examined the relationship between long‐term exposure to PM2.5 constituents and the risk of arthritis and rheumatoid arthritis, with the exposure period extending from recruitment until self‐reported outcomes, death, loss to follow‐up, or end of follow‐up. Additionally, the study assessed whether there was an interactive effect between PM2.5 and green space on these risks. We gathered cohort data on 18,649 individuals aged ≥45 years. We applied generalized linear mixed‐effects models to estimate the effects of PM2.5 constituents, NDVI, and their interaction on arthritis and rheumatoid arthritis. The quantile g‐computation and weighted quantile sum regression model were applied to estimate the combined effect of PM2.5 constituents. Our results showed that exposure to single and mixed PM2.5 constituents adversely affected arthritis and rheumatoid arthritis, and was mainly attributed to the black carbon component. We observed “U” or “J” shaped exposure‐response curves for the effects of PM2.5, OM, NO3− and NH4+ exposure on the development of arthritis/rheumatoid arthritis. Additionally, the odds ratio of arthritis for per interquartile range (IQR) increase in PM2.5 was 1.209 (95% CI:1.198, 1.221), per 0.1‐unit decrease in NDVI was 1.091 (95% CI:1.033, 1.151), and the interaction term was 1.005 (95% CI:1.002, 1.007). These findings flesh out the existing evidence for PM2.5 constituents, NDVI and arthritis, rheumatoid arthritis, but the underlying mechanisms still require further exploration.https://doi.org/10.1029/2024GH001132arthritisrheumatoid arthritisPM2.5 constituentsgreen space |
| spellingShingle | Yi‐Sheng He Yi‐Qing Xu Fan Cao Zhao‐Xing Gao Man Ge Tian He Peng Zhang Chan‐Na Zhao Peng Wang Zhiwei Xu Hai‐Feng Pan Association of Long‐Term Exposure to PM2.5 Constituents and Green Space With Arthritis and Rheumatoid Arthritis GeoHealth arthritis rheumatoid arthritis PM2.5 constituents green space |
| title | Association of Long‐Term Exposure to PM2.5 Constituents and Green Space With Arthritis and Rheumatoid Arthritis |
| title_full | Association of Long‐Term Exposure to PM2.5 Constituents and Green Space With Arthritis and Rheumatoid Arthritis |
| title_fullStr | Association of Long‐Term Exposure to PM2.5 Constituents and Green Space With Arthritis and Rheumatoid Arthritis |
| title_full_unstemmed | Association of Long‐Term Exposure to PM2.5 Constituents and Green Space With Arthritis and Rheumatoid Arthritis |
| title_short | Association of Long‐Term Exposure to PM2.5 Constituents and Green Space With Arthritis and Rheumatoid Arthritis |
| title_sort | association of long term exposure to pm2 5 constituents and green space with arthritis and rheumatoid arthritis |
| topic | arthritis rheumatoid arthritis PM2.5 constituents green space |
| url | https://doi.org/10.1029/2024GH001132 |
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