Multifunctional hydrogels loaded with tellurium nanozyme for spinal cord injury repair
Spinal cord injury (SCI) results in severe neurological deficits due to disrupted neural pathways. While the spinal cord possesses limited self-repair capabilities, recent advancements in hydrogel-based therapies have shown promise. Polyphenol-based hydrogels, known for their neuroprotective propert...
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| Format: | Article |
| Language: | English |
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Elsevier
2024-12-01
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| Series: | Materials Today Bio |
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| Online Access: | http://www.sciencedirect.com/science/article/pii/S2590006424004009 |
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| author | Jian Meng Jingjing Sun Jiali Kang Shilei Ren Miaomiao Xu Runzhi Li Xuhui Zhao Yitong Yuan Lei Xin Ruiping Zhang |
| author_facet | Jian Meng Jingjing Sun Jiali Kang Shilei Ren Miaomiao Xu Runzhi Li Xuhui Zhao Yitong Yuan Lei Xin Ruiping Zhang |
| author_sort | Jian Meng |
| collection | DOAJ |
| description | Spinal cord injury (SCI) results in severe neurological deficits due to disrupted neural pathways. While the spinal cord possesses limited self-repair capabilities, recent advancements in hydrogel-based therapies have shown promise. Polyphenol-based hydrogels, known for their neuroprotective properties, offer a suitable microenvironment for neural regeneration. In this study, a novel poly(lipoic acid)/poly(dopamine) adhesive hydrogel was developed as a versatile platform for delivering therapeutic agents. This hydrogel was loaded with methylcobalamin, a neurotrophic factor, and tellurium nanoenzymes, potent antioxidants. The nanoenzymes effectively mitigated oxidative stress and inflammation, while methylcobalamin promoted nerve regeneration. The combined therapeutic effects of the nanoenzymatic hydrogel demonstrated significant efficacy in repairing spinal cord injuries, highlighting its potential as a promising strategy for treating this debilitating condition. |
| format | Article |
| id | doaj-art-9e86b9999c5348bb8144a31d2099e4e3 |
| institution | OA Journals |
| issn | 2590-0064 |
| language | English |
| publishDate | 2024-12-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Materials Today Bio |
| spelling | doaj-art-9e86b9999c5348bb8144a31d2099e4e32025-08-20T02:37:43ZengElsevierMaterials Today Bio2590-00642024-12-012910133910.1016/j.mtbio.2024.101339Multifunctional hydrogels loaded with tellurium nanozyme for spinal cord injury repairJian Meng0Jingjing Sun1Jiali Kang2Shilei Ren3Miaomiao Xu4Runzhi Li5Xuhui Zhao6Yitong Yuan7Lei Xin8Ruiping Zhang9Third Hospital of Shanxi Medical University, Shanxi Bethune Hospital, Shanxi Academy of Medical Sciences, Tongji Shanxi Hospital, Taiyuan, 030032, Shanxi, China; The Radiology Department of Shanxi Provincial People’ Hospital, Shanxi Medical University, Taiyuan, 030012, ChinaZhenjiang Mental Health Center, Zhenjiang, 212000, Jiangsu, ChinaCollege of Basic Medical, Shanxi Medical University, Taiyuan, 030012, ChinaThird Hospital of Shanxi Medical University, Shanxi Bethune Hospital, Shanxi Academy of Medical Sciences, Tongji Shanxi Hospital, Taiyuan, 030032, Shanxi, China; Corresponding authors.College of Basic Medical, Shanxi Medical University, Taiyuan, 030012, ChinaThe Radiology Department of Shanxi Provincial People’ Hospital, Shanxi Medical University, Taiyuan, 030012, ChinaThe Radiology Department of Shanxi Provincial People’ Hospital, Shanxi Medical University, Taiyuan, 030012, ChinaCollege of Basic Medical, Shanxi Medical University, Taiyuan, 030012, China; Corresponding author.Shanxi Province Cancer Hospital, Shanxi Hospital Affiliated to Cancer Hospital, Chinese Academy of Medical Sciences, Cancer Hospital Affiliated to Shanxi Medical University, Taiyuan, 030013, China; Corresponding authors.The Radiology Department of Shanxi Provincial People’ Hospital, Shanxi Medical University, Taiyuan, 030012, China; Corresponding author.Spinal cord injury (SCI) results in severe neurological deficits due to disrupted neural pathways. While the spinal cord possesses limited self-repair capabilities, recent advancements in hydrogel-based therapies have shown promise. Polyphenol-based hydrogels, known for their neuroprotective properties, offer a suitable microenvironment for neural regeneration. In this study, a novel poly(lipoic acid)/poly(dopamine) adhesive hydrogel was developed as a versatile platform for delivering therapeutic agents. This hydrogel was loaded with methylcobalamin, a neurotrophic factor, and tellurium nanoenzymes, potent antioxidants. The nanoenzymes effectively mitigated oxidative stress and inflammation, while methylcobalamin promoted nerve regeneration. The combined therapeutic effects of the nanoenzymatic hydrogel demonstrated significant efficacy in repairing spinal cord injuries, highlighting its potential as a promising strategy for treating this debilitating condition.http://www.sciencedirect.com/science/article/pii/S2590006424004009Spinal cord injuryTellurium nanoenzymeHydrogelPolyphenol |
| spellingShingle | Jian Meng Jingjing Sun Jiali Kang Shilei Ren Miaomiao Xu Runzhi Li Xuhui Zhao Yitong Yuan Lei Xin Ruiping Zhang Multifunctional hydrogels loaded with tellurium nanozyme for spinal cord injury repair Materials Today Bio Spinal cord injury Tellurium nanoenzyme Hydrogel Polyphenol |
| title | Multifunctional hydrogels loaded with tellurium nanozyme for spinal cord injury repair |
| title_full | Multifunctional hydrogels loaded with tellurium nanozyme for spinal cord injury repair |
| title_fullStr | Multifunctional hydrogels loaded with tellurium nanozyme for spinal cord injury repair |
| title_full_unstemmed | Multifunctional hydrogels loaded with tellurium nanozyme for spinal cord injury repair |
| title_short | Multifunctional hydrogels loaded with tellurium nanozyme for spinal cord injury repair |
| title_sort | multifunctional hydrogels loaded with tellurium nanozyme for spinal cord injury repair |
| topic | Spinal cord injury Tellurium nanoenzyme Hydrogel Polyphenol |
| url | http://www.sciencedirect.com/science/article/pii/S2590006424004009 |
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