Fyn, an important molecule in the brain, is a potential therapeutic target for brain tumours
Under normal physiological conditions, Fyn, a nonreceptor tyrosine kinase, is involved in signal transduction pathways in the nervous system and in the formation and activation of T lymphocytes. Fyn is a member of the Src family of kinases (SFKs) and plays a role in cell morphogenic transformation,...
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| Language: | English |
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Frontiers Media S.A.
2024-12-01
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| Series: | Frontiers in Pharmacology |
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| Online Access: | https://www.frontiersin.org/articles/10.3389/fphar.2024.1485919/full |
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| author | Chongxi Xu Yi Tang Xing Lu Ruiqi Chen |
| author_facet | Chongxi Xu Yi Tang Xing Lu Ruiqi Chen |
| author_sort | Chongxi Xu |
| collection | DOAJ |
| description | Under normal physiological conditions, Fyn, a nonreceptor tyrosine kinase, is involved in signal transduction pathways in the nervous system and in the formation and activation of T lymphocytes. Fyn is a member of the Src family of kinases (SFKs) and plays a role in cell morphogenic transformation, motility, proliferation, and death, which in turn influences the development and progression of various cancer types. SFKs are overexpressed or hyperactive in tumours, and they are engaged in several signalling pathways that lead to tumour development. Inhibition of Fyn can enhance patient outcomes and prolong survival. Thus, Fyn is a desirable therapeutic target in a variety of tumour types. To lay the groundwork for further investigation and targeted therapy in tumours, in this article, we review the most recent findings on the function of Fyn in tumours, with an emphasis on its role in gliomas. Understanding the function of Fyn during tumourigenesis and development and in resistance to anticancer therapeutic agents can aid in the development and application of innovative medicines that specifically target this kinase, thus improving the management of cancers. |
| format | Article |
| id | doaj-art-9e805b6ee44f4b80990f79cf466efab2 |
| institution | OA Journals |
| issn | 1663-9812 |
| language | English |
| publishDate | 2024-12-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Pharmacology |
| spelling | doaj-art-9e805b6ee44f4b80990f79cf466efab22025-08-20T02:30:32ZengFrontiers Media S.A.Frontiers in Pharmacology1663-98122024-12-011510.3389/fphar.2024.14859191485919Fyn, an important molecule in the brain, is a potential therapeutic target for brain tumoursChongxi Xu0Yi Tang1Xing Lu2Ruiqi Chen3Department of Neurosurgery, West China Hospital, Sichuan University, Chengdu, ChinaDepartment of Pharmacy, Sichuan Clinical Research Center for Cancer, Sichuan Cancer Center, Sichuan Cancer Hospital & Institute, Affiliated Cancer Hospital of University of Electronic Science and Technology of China, Chengdu, ChinaDepartment of Gynecological Nursing, West China Second Hospital, Sichuan University, Chengdu, ChinaDepartment of Neurosurgery, West China Hospital, Sichuan University, Chengdu, ChinaUnder normal physiological conditions, Fyn, a nonreceptor tyrosine kinase, is involved in signal transduction pathways in the nervous system and in the formation and activation of T lymphocytes. Fyn is a member of the Src family of kinases (SFKs) and plays a role in cell morphogenic transformation, motility, proliferation, and death, which in turn influences the development and progression of various cancer types. SFKs are overexpressed or hyperactive in tumours, and they are engaged in several signalling pathways that lead to tumour development. Inhibition of Fyn can enhance patient outcomes and prolong survival. Thus, Fyn is a desirable therapeutic target in a variety of tumour types. To lay the groundwork for further investigation and targeted therapy in tumours, in this article, we review the most recent findings on the function of Fyn in tumours, with an emphasis on its role in gliomas. Understanding the function of Fyn during tumourigenesis and development and in resistance to anticancer therapeutic agents can aid in the development and application of innovative medicines that specifically target this kinase, thus improving the management of cancers.https://www.frontiersin.org/articles/10.3389/fphar.2024.1485919/fullFynbrain tumoursSrc family of kinasesgliomastherapeutic target |
| spellingShingle | Chongxi Xu Yi Tang Xing Lu Ruiqi Chen Fyn, an important molecule in the brain, is a potential therapeutic target for brain tumours Frontiers in Pharmacology Fyn brain tumours Src family of kinases gliomas therapeutic target |
| title | Fyn, an important molecule in the brain, is a potential therapeutic target for brain tumours |
| title_full | Fyn, an important molecule in the brain, is a potential therapeutic target for brain tumours |
| title_fullStr | Fyn, an important molecule in the brain, is a potential therapeutic target for brain tumours |
| title_full_unstemmed | Fyn, an important molecule in the brain, is a potential therapeutic target for brain tumours |
| title_short | Fyn, an important molecule in the brain, is a potential therapeutic target for brain tumours |
| title_sort | fyn an important molecule in the brain is a potential therapeutic target for brain tumours |
| topic | Fyn brain tumours Src family of kinases gliomas therapeutic target |
| url | https://www.frontiersin.org/articles/10.3389/fphar.2024.1485919/full |
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