Murine MPDZ‐linked hydrocephalus is caused by hyperpermeability of the choroid plexus

Murine MPDZ‐linked hydrocephalus is caused by hyperpermeability of the choroid plexus

Abstract Though congenital hydrocephalus is heritable, it has been linked only to eight genes, one of which is MPDZ. Humans and mice that carry a truncated version of MPDZ incur severe hydrocephalus resulting in acute morbidity and lethality. We show by magnetic resonance imaging that contrast mediu...

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Main Authors: Junning Yang, Claire Simonneau, Robert Kilker, Laura Oakley, Matthew D Byrne, Zuzana Nichtova, Ioana Stefanescu, Fnu Pardeep‐Kumar, Sushil Tripathi, Eric Londin, Pascale Saugier‐Veber, Belinda Willard, Mathew Thakur, Stephen Pickup, Hiroshi Ishikawa, Horst Schroten, Richard Smeyne, Arie Horowitz
Format: Article
Language:English
Published: Springer Nature 2018-12-01
Series:EMBO Molecular Medicine
Subjects:
cerebrospinal fluid
choroid plexus
hydrocephalus
magnetic resonance imaging
proteomics
Online Access:https://doi.org/10.15252/emmm.201809540
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