Asparagus officinalis polysaccharide-loaded liposomal gels alleviate skin inflammation via inhibiting the NF-κB/MAPK pathways
Asparagus officinalis L. has long been used as a medicinal food since ancient times. Despite identifying the active compounds, the anti-inflammatory properties of these compounds remain underexplored. This study explored the anti-inflammatory activity of white asparagus polysaccharide (WAPS) against...
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| Format: | Article |
| Language: | English |
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Elsevier
2025-02-01
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| Series: | Journal of Functional Foods |
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| Online Access: | http://www.sciencedirect.com/science/article/pii/S1756464625000210 |
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| author | Rongrui Zhang Yu Xiong Yujin Ma Yafei Ma Nuo Li Yan Ren Lili He Lu Han Jun Ni Zhi-xiang Yuan |
| author_facet | Rongrui Zhang Yu Xiong Yujin Ma Yafei Ma Nuo Li Yan Ren Lili He Lu Han Jun Ni Zhi-xiang Yuan |
| author_sort | Rongrui Zhang |
| collection | DOAJ |
| description | Asparagus officinalis L. has long been used as a medicinal food since ancient times. Despite identifying the active compounds, the anti-inflammatory properties of these compounds remain underexplored. This study explored the anti-inflammatory activity of white asparagus polysaccharide (WAPS) against skin inflammation. WAPS, a pectin polysaccharide, was identified to coexist with α-glycosidic and β-glycosidic linkages glucan and probably has triple-helix confirmation suggested by Fourier-transform infrared and nuclear magnetic resonance spectroscopy. Cellular experiments indicated that WAPS attenuated the expression of inflammatory cytokines and enhanced macrophage viability. Skin inflammation was ameliorated with WAPS liposomal-loaded gel; the mechanism regulating NF-κB/MAPK signal pathways was further explored. Notably, the formulation augmented the bioavailability of WAPS, downregulated the expression of NF-κB p50 and MMP9, and amplified the inhibitory potential of WAPS against inflammation. This study suggests WAPS as a medicinal substance with anti-inflammatory efficacy. |
| format | Article |
| id | doaj-art-9e7d6a659785478a9702587787007ff0 |
| institution | Kabale University |
| issn | 1756-4646 |
| language | English |
| publishDate | 2025-02-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Journal of Functional Foods |
| spelling | doaj-art-9e7d6a659785478a9702587787007ff02025-02-09T04:59:56ZengElsevierJournal of Functional Foods1756-46462025-02-01125106679Asparagus officinalis polysaccharide-loaded liposomal gels alleviate skin inflammation via inhibiting the NF-κB/MAPK pathwaysRongrui Zhang0Yu Xiong1Yujin Ma2Yafei Ma3Nuo Li4Yan Ren5Lili He6Lu Han7Jun Ni8Zhi-xiang Yuan9Key Laboratory of Research and Application of Ethnic Medicine Processing and Preparation on the Qinghai-Tibet Plateau, College of Pharmacy and Food, Southwest Minzu University, Chengdu 610041, ChinaKey Laboratory of Research and Application of Ethnic Medicine Processing and Preparation on the Qinghai-Tibet Plateau, College of Pharmacy and Food, Southwest Minzu University, Chengdu 610041, ChinaKey Laboratory of Research and Application of Ethnic Medicine Processing and Preparation on the Qinghai-Tibet Plateau, College of Pharmacy and Food, Southwest Minzu University, Chengdu 610041, ChinaKey Laboratory of Research and Application of Ethnic Medicine Processing and Preparation on the Qinghai-Tibet Plateau, College of Pharmacy and Food, Southwest Minzu University, Chengdu 610041, ChinaKey Laboratory of Research and Application of Ethnic Medicine Processing and Preparation on the Qinghai-Tibet Plateau, College of Pharmacy and Food, Southwest Minzu University, Chengdu 610041, ChinaKey Laboratory of Research and Application of Ethnic Medicine Processing and Preparation on the Qinghai-Tibet Plateau, College of Pharmacy and Food, Southwest Minzu University, Chengdu 610041, ChinaKey Laboratory of Research and Application of Ethnic Medicine Processing and Preparation on the Qinghai-Tibet Plateau, College of Pharmacy and Food, Southwest Minzu University, Chengdu 610041, ChinaKey Laboratory of Research and Application of Ethnic Medicine Processing and Preparation on the Qinghai-Tibet Plateau, College of Pharmacy and Food, Southwest Minzu University, Chengdu 610041, ChinaDepartment of Dermatology& Medical Cosmetology Department, West China School of Public Health and West China Fourth Hospital, Sichuan University, Chengdu, Sichuan, China; Corresponding authors.Key Laboratory of Research and Application of Ethnic Medicine Processing and Preparation on the Qinghai-Tibet Plateau, College of Pharmacy and Food, Southwest Minzu University, Chengdu 610041, China; Corresponding authors.Asparagus officinalis L. has long been used as a medicinal food since ancient times. Despite identifying the active compounds, the anti-inflammatory properties of these compounds remain underexplored. This study explored the anti-inflammatory activity of white asparagus polysaccharide (WAPS) against skin inflammation. WAPS, a pectin polysaccharide, was identified to coexist with α-glycosidic and β-glycosidic linkages glucan and probably has triple-helix confirmation suggested by Fourier-transform infrared and nuclear magnetic resonance spectroscopy. Cellular experiments indicated that WAPS attenuated the expression of inflammatory cytokines and enhanced macrophage viability. Skin inflammation was ameliorated with WAPS liposomal-loaded gel; the mechanism regulating NF-κB/MAPK signal pathways was further explored. Notably, the formulation augmented the bioavailability of WAPS, downregulated the expression of NF-κB p50 and MMP9, and amplified the inhibitory potential of WAPS against inflammation. This study suggests WAPS as a medicinal substance with anti-inflammatory efficacy.http://www.sciencedirect.com/science/article/pii/S1756464625000210White asparagusPolysaccharideInflammatory skin diseaseAnti-inflammationLiposomal gels |
| spellingShingle | Rongrui Zhang Yu Xiong Yujin Ma Yafei Ma Nuo Li Yan Ren Lili He Lu Han Jun Ni Zhi-xiang Yuan Asparagus officinalis polysaccharide-loaded liposomal gels alleviate skin inflammation via inhibiting the NF-κB/MAPK pathways Journal of Functional Foods White asparagus Polysaccharide Inflammatory skin disease Anti-inflammation Liposomal gels |
| title | Asparagus officinalis polysaccharide-loaded liposomal gels alleviate skin inflammation via inhibiting the NF-κB/MAPK pathways |
| title_full | Asparagus officinalis polysaccharide-loaded liposomal gels alleviate skin inflammation via inhibiting the NF-κB/MAPK pathways |
| title_fullStr | Asparagus officinalis polysaccharide-loaded liposomal gels alleviate skin inflammation via inhibiting the NF-κB/MAPK pathways |
| title_full_unstemmed | Asparagus officinalis polysaccharide-loaded liposomal gels alleviate skin inflammation via inhibiting the NF-κB/MAPK pathways |
| title_short | Asparagus officinalis polysaccharide-loaded liposomal gels alleviate skin inflammation via inhibiting the NF-κB/MAPK pathways |
| title_sort | asparagus officinalis polysaccharide loaded liposomal gels alleviate skin inflammation via inhibiting the nf κb mapk pathways |
| topic | White asparagus Polysaccharide Inflammatory skin disease Anti-inflammation Liposomal gels |
| url | http://www.sciencedirect.com/science/article/pii/S1756464625000210 |
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