Asparagus officinalis polysaccharide-loaded liposomal gels alleviate skin inflammation via inhibiting the NF-κB/MAPK pathways
Asparagus officinalis L. has long been used as a medicinal food since ancient times. Despite identifying the active compounds, the anti-inflammatory properties of these compounds remain underexplored. This study explored the anti-inflammatory activity of white asparagus polysaccharide (WAPS) against...
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| Main Authors: | , , , , , , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
Elsevier
2025-02-01
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| Series: | Journal of Functional Foods |
| Subjects: | |
| Online Access: | http://www.sciencedirect.com/science/article/pii/S1756464625000210 |
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| Summary: | Asparagus officinalis L. has long been used as a medicinal food since ancient times. Despite identifying the active compounds, the anti-inflammatory properties of these compounds remain underexplored. This study explored the anti-inflammatory activity of white asparagus polysaccharide (WAPS) against skin inflammation. WAPS, a pectin polysaccharide, was identified to coexist with α-glycosidic and β-glycosidic linkages glucan and probably has triple-helix confirmation suggested by Fourier-transform infrared and nuclear magnetic resonance spectroscopy. Cellular experiments indicated that WAPS attenuated the expression of inflammatory cytokines and enhanced macrophage viability. Skin inflammation was ameliorated with WAPS liposomal-loaded gel; the mechanism regulating NF-κB/MAPK signal pathways was further explored. Notably, the formulation augmented the bioavailability of WAPS, downregulated the expression of NF-κB p50 and MMP9, and amplified the inhibitory potential of WAPS against inflammation. This study suggests WAPS as a medicinal substance with anti-inflammatory efficacy. |
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| ISSN: | 1756-4646 |