Effect of Genetic-Environmental Interaction on Chinese Childhood Myopia

Objective. The purpose of this study was to evaluate the effect of genetic-environmental interaction on myopia in Chinese children aged 6 to 9 years. Methods. Students had the physical examination and were required to provide basic demographic information. Their families were asked to fill in a ques...

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Main Authors: Xiyan Zhang, Yan Wang, Chenwei Pan, Wenyi Yang, Yao Xiang, Jie Yang, Fengyun Zhang
Format: Article
Language:English
Published: Wiley 2020-01-01
Series:Journal of Ophthalmology
Online Access:http://dx.doi.org/10.1155/2020/6308289
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author Xiyan Zhang
Yan Wang
Chenwei Pan
Wenyi Yang
Yao Xiang
Jie Yang
Fengyun Zhang
author_facet Xiyan Zhang
Yan Wang
Chenwei Pan
Wenyi Yang
Yao Xiang
Jie Yang
Fengyun Zhang
author_sort Xiyan Zhang
collection DOAJ
description Objective. The purpose of this study was to evaluate the effect of genetic-environmental interaction on myopia in Chinese children aged 6 to 9 years. Methods. Students had the physical examination and were required to provide basic demographic information. Their families were asked to fill in a questionnaire concerning factors related to myopia. Multiple regression analysis was performed, and adjusted risk ratio values were calculated to assess the role between gene and environment. Value of the environmental and genetic index (EGI) was calculated to demonstrate the effect of genetic-environmental interaction on myopia. Results. The prevalence of myopia maintained at a high level. EGI was calculated as 0.125 suggesting that genetic factors may play the 12.5% role in the formation of myopia and environmental factors may play a role of 87.5% in the formation of myopia. Conclusions. For young pupils aged 6 to 9 years, myopia prevalence maintained at a high level, and duration of homework time and staring at electronic screen were the strongest factors associated with myopia. The calculated value of EGI was low, which suggests that environmental factors may play the leading role in the formation of myopia. A long-term follow-up research to improve the accuracy value of EGI is our next job.
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institution Kabale University
issn 2090-004X
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language English
publishDate 2020-01-01
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series Journal of Ophthalmology
spelling doaj-art-9e7cfdae2d224f7c9e1485ab696b9a412025-02-03T01:20:20ZengWileyJournal of Ophthalmology2090-004X2090-00582020-01-01202010.1155/2020/63082896308289Effect of Genetic-Environmental Interaction on Chinese Childhood MyopiaXiyan Zhang0Yan Wang1Chenwei Pan2Wenyi Yang3Yao Xiang4Jie Yang5Fengyun Zhang6Department of Child and Adolescent Health Promotion, Jiangsu Provincial Center for Disease Control and Prevention, Jiangsu, ChinaDepartment of Child and Adolescent Health Promotion, Jiangsu Provincial Center for Disease Control and Prevention, Jiangsu, ChinaSchool of Public Health, Soochow University, Suzhou, ChinaDepartment of Child and Adolescent Health Promotion, Jiangsu Provincial Center for Disease Control and Prevention, Jiangsu, ChinaDepartment of Child and Adolescent Health Promotion, Jiangsu Provincial Center for Disease Control and Prevention, Jiangsu, ChinaDepartment of Child and Adolescent Health Promotion, Jiangsu Provincial Center for Disease Control and Prevention, Jiangsu, ChinaDepartment of Child and Adolescent Health Promotion, Jiangsu Provincial Center for Disease Control and Prevention, Jiangsu, ChinaObjective. The purpose of this study was to evaluate the effect of genetic-environmental interaction on myopia in Chinese children aged 6 to 9 years. Methods. Students had the physical examination and were required to provide basic demographic information. Their families were asked to fill in a questionnaire concerning factors related to myopia. Multiple regression analysis was performed, and adjusted risk ratio values were calculated to assess the role between gene and environment. Value of the environmental and genetic index (EGI) was calculated to demonstrate the effect of genetic-environmental interaction on myopia. Results. The prevalence of myopia maintained at a high level. EGI was calculated as 0.125 suggesting that genetic factors may play the 12.5% role in the formation of myopia and environmental factors may play a role of 87.5% in the formation of myopia. Conclusions. For young pupils aged 6 to 9 years, myopia prevalence maintained at a high level, and duration of homework time and staring at electronic screen were the strongest factors associated with myopia. The calculated value of EGI was low, which suggests that environmental factors may play the leading role in the formation of myopia. A long-term follow-up research to improve the accuracy value of EGI is our next job.http://dx.doi.org/10.1155/2020/6308289
spellingShingle Xiyan Zhang
Yan Wang
Chenwei Pan
Wenyi Yang
Yao Xiang
Jie Yang
Fengyun Zhang
Effect of Genetic-Environmental Interaction on Chinese Childhood Myopia
Journal of Ophthalmology
title Effect of Genetic-Environmental Interaction on Chinese Childhood Myopia
title_full Effect of Genetic-Environmental Interaction on Chinese Childhood Myopia
title_fullStr Effect of Genetic-Environmental Interaction on Chinese Childhood Myopia
title_full_unstemmed Effect of Genetic-Environmental Interaction on Chinese Childhood Myopia
title_short Effect of Genetic-Environmental Interaction on Chinese Childhood Myopia
title_sort effect of genetic environmental interaction on chinese childhood myopia
url http://dx.doi.org/10.1155/2020/6308289
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