Structural substitutions on the methoxybenzene ring retain the biological activity of the zaxinone mimics MiZax3
The plant growth regulator zaxinone is essential for proper rice growth and development. Additionally, zaxinone and its two synthetic mimics, MiZax3 and MiZax5, have been shown to significantly promote crop growth and reduce infestation by the root parasitic plant Striga by suppressing strigolactone...
Saved in:
| Main Authors: | , , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Frontiers Media S.A.
2025-07-01
|
| Series: | Frontiers in Plant Science |
| Subjects: | |
| Online Access: | https://www.frontiersin.org/articles/10.3389/fpls.2025.1631066/full |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
| _version_ | 1849430272784728064 |
|---|---|
| author | Jian You Wang Muhammad Jamil Lamis M. Tareq Berqdar Ikuo Takahashi Tsuyoshi Ota Tadao Asami Salim Al-Babili Salim Al-Babili Salim Al-Babili |
| author_facet | Jian You Wang Muhammad Jamil Lamis M. Tareq Berqdar Ikuo Takahashi Tsuyoshi Ota Tadao Asami Salim Al-Babili Salim Al-Babili Salim Al-Babili |
| author_sort | Jian You Wang |
| collection | DOAJ |
| description | The plant growth regulator zaxinone is essential for proper rice growth and development. Additionally, zaxinone and its two synthetic mimics, MiZax3 and MiZax5, have been shown to significantly promote crop growth and reduce infestation by the root parasitic plant Striga by suppressing strigolactone (SL) production, highlighting their potential for field application. Here, we developed 4 new MiZax through structural modifications of the methoxybenzene ring in MiZax3 and evaluated their effects on plant growth and SL exudation. These newly developed mimics enhanced rice growth and reduced SL release without compromising the bioactivity of the lead compound MiZax3. Our findings underscore their potential to guide future chemical design efforts aimed at exploring zaxinone biology. |
| format | Article |
| id | doaj-art-9e7c69e2b4874d6ca81ebe91933ac7bd |
| institution | Kabale University |
| issn | 1664-462X |
| language | English |
| publishDate | 2025-07-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Plant Science |
| spelling | doaj-art-9e7c69e2b4874d6ca81ebe91933ac7bd2025-08-20T03:28:04ZengFrontiers Media S.A.Frontiers in Plant Science1664-462X2025-07-011610.3389/fpls.2025.16310661631066Structural substitutions on the methoxybenzene ring retain the biological activity of the zaxinone mimics MiZax3Jian You Wang0Muhammad Jamil1Lamis M. Tareq Berqdar2Ikuo Takahashi3Tsuyoshi Ota4Tadao Asami5Salim Al-Babili6Salim Al-Babili7Salim Al-Babili8The BioActives Lab, Center for Desert Agriculture, King Abdullah University of Science and Technology, Thuwal, Saudi ArabiaThe BioActives Lab, Center for Desert Agriculture, King Abdullah University of Science and Technology, Thuwal, Saudi ArabiaThe BioActives Lab, Center for Desert Agriculture, King Abdullah University of Science and Technology, Thuwal, Saudi ArabiaKihara Institute for Biological Research, Yokohama City University, Yokohama, Kanagawa, JapanKihara Institute for Biological Research, Yokohama City University, Yokohama, Kanagawa, JapanKihara Institute for Biological Research, Yokohama City University, Yokohama, Kanagawa, JapanThe BioActives Lab, Center for Desert Agriculture, King Abdullah University of Science and Technology, Thuwal, Saudi ArabiaPlant Science Program, Biological and Environmental Science and Engineering Division, King Abdullah University of Science and Technology (KAUST), Thuwal, Saudi ArabiaCenter of Excellence – Sustainable Food Security, King Abdullah University of Science and Technology (KAUST), Thuwal, Saudi ArabiaThe plant growth regulator zaxinone is essential for proper rice growth and development. Additionally, zaxinone and its two synthetic mimics, MiZax3 and MiZax5, have been shown to significantly promote crop growth and reduce infestation by the root parasitic plant Striga by suppressing strigolactone (SL) production, highlighting their potential for field application. Here, we developed 4 new MiZax through structural modifications of the methoxybenzene ring in MiZax3 and evaluated their effects on plant growth and SL exudation. These newly developed mimics enhanced rice growth and reduced SL release without compromising the bioactivity of the lead compound MiZax3. Our findings underscore their potential to guide future chemical design efforts aimed at exploring zaxinone biology.https://www.frontiersin.org/articles/10.3389/fpls.2025.1631066/fullzaxinonezaxinone mimicsMiZaxapocarotenoidsstrigolactonesrice (Oryza sativa) |
| spellingShingle | Jian You Wang Muhammad Jamil Lamis M. Tareq Berqdar Ikuo Takahashi Tsuyoshi Ota Tadao Asami Salim Al-Babili Salim Al-Babili Salim Al-Babili Structural substitutions on the methoxybenzene ring retain the biological activity of the zaxinone mimics MiZax3 Frontiers in Plant Science zaxinone zaxinone mimics MiZax apocarotenoids strigolactones rice (Oryza sativa) |
| title | Structural substitutions on the methoxybenzene ring retain the biological activity of the zaxinone mimics MiZax3 |
| title_full | Structural substitutions on the methoxybenzene ring retain the biological activity of the zaxinone mimics MiZax3 |
| title_fullStr | Structural substitutions on the methoxybenzene ring retain the biological activity of the zaxinone mimics MiZax3 |
| title_full_unstemmed | Structural substitutions on the methoxybenzene ring retain the biological activity of the zaxinone mimics MiZax3 |
| title_short | Structural substitutions on the methoxybenzene ring retain the biological activity of the zaxinone mimics MiZax3 |
| title_sort | structural substitutions on the methoxybenzene ring retain the biological activity of the zaxinone mimics mizax3 |
| topic | zaxinone zaxinone mimics MiZax apocarotenoids strigolactones rice (Oryza sativa) |
| url | https://www.frontiersin.org/articles/10.3389/fpls.2025.1631066/full |
| work_keys_str_mv | AT jianyouwang structuralsubstitutionsonthemethoxybenzeneringretainthebiologicalactivityofthezaxinonemimicsmizax3 AT muhammadjamil structuralsubstitutionsonthemethoxybenzeneringretainthebiologicalactivityofthezaxinonemimicsmizax3 AT lamismtareqberqdar structuralsubstitutionsonthemethoxybenzeneringretainthebiologicalactivityofthezaxinonemimicsmizax3 AT ikuotakahashi structuralsubstitutionsonthemethoxybenzeneringretainthebiologicalactivityofthezaxinonemimicsmizax3 AT tsuyoshiota structuralsubstitutionsonthemethoxybenzeneringretainthebiologicalactivityofthezaxinonemimicsmizax3 AT tadaoasami structuralsubstitutionsonthemethoxybenzeneringretainthebiologicalactivityofthezaxinonemimicsmizax3 AT salimalbabili structuralsubstitutionsonthemethoxybenzeneringretainthebiologicalactivityofthezaxinonemimicsmizax3 AT salimalbabili structuralsubstitutionsonthemethoxybenzeneringretainthebiologicalactivityofthezaxinonemimicsmizax3 AT salimalbabili structuralsubstitutionsonthemethoxybenzeneringretainthebiologicalactivityofthezaxinonemimicsmizax3 |