Endobronchial mucormycosis successfully treated with pharmacologic therapy: A rare case report
A 36-year-old female patient who did not have a previous history of any disease visited our institution because of shortness of breath. The patient was first diagnosed with diabetes upon admission. Chest computed tomography (CT) scan showed a lesion that completely obstructed the left main bronchus...
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Elsevier
2025-01-01
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| Series: | Respiratory Medicine Case Reports |
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| Online Access: | http://www.sciencedirect.com/science/article/pii/S2213007125000681 |
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| author | Soo Kyun Jung Keum-Ju Choi |
| author_facet | Soo Kyun Jung Keum-Ju Choi |
| author_sort | Soo Kyun Jung |
| collection | DOAJ |
| description | A 36-year-old female patient who did not have a previous history of any disease visited our institution because of shortness of breath. The patient was first diagnosed with diabetes upon admission. Chest computed tomography (CT) scan showed a lesion that completely obstructed the left main bronchus and pneumonia. Due to hypoxia, the patient was placed on mechanical ventilation and admitted to the intensive care unit. Bronchoscopy was performed, and results revealed complete atelectasis with a soft tissue mass at the left main bronchus. Bronchoscopic biopsy confirmed that the patient's condition was endobronchial mucormycosis. Treatment with liposomal amphotericin B was started. After 1 week, atelectasis improved based on the chest radiography result. The patient was successfully extubated. However, 4 weeks after treatment, bronchoscopy still showed complete atelectasis with purulent secretion and a soft tissue mass. After 6 weeks, liposomal amphotericin B was switched to isavuconazole, with a duration of 2 months. After completing the treatment, bronchoscopy showed no endobronchial lesion. Herein, we present a rare case of rapidly progressing endobronchial mucormycosis in a young patient who did not have a previous history of any disease and who was successfully managed with pharmacological therapy. |
| format | Article |
| id | doaj-art-9e7afcd3c25f4c8a9ec9d2042f02cd53 |
| institution | DOAJ |
| issn | 2213-0071 |
| language | English |
| publishDate | 2025-01-01 |
| publisher | Elsevier |
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| series | Respiratory Medicine Case Reports |
| spelling | doaj-art-9e7afcd3c25f4c8a9ec9d2042f02cd532025-08-20T03:15:37ZengElsevierRespiratory Medicine Case Reports2213-00712025-01-015610223210.1016/j.rmcr.2025.102232Endobronchial mucormycosis successfully treated with pharmacologic therapy: A rare case reportSoo Kyun Jung0Keum-Ju Choi1Department of Internal Medicine, Daegu Catholic University Medical Center, Daegu Catholic University School of Medicine, Daegu, South KoreaCorresponding author.Department of Internal Medicine, Daegu Catholic University School of Medicine, Daegu, Korea 33, Duryugongwon-ro 17gil, Namgu, Daegu, 42472, South Korea.; Department of Internal Medicine, Daegu Catholic University Medical Center, Daegu Catholic University School of Medicine, Daegu, South KoreaA 36-year-old female patient who did not have a previous history of any disease visited our institution because of shortness of breath. The patient was first diagnosed with diabetes upon admission. Chest computed tomography (CT) scan showed a lesion that completely obstructed the left main bronchus and pneumonia. Due to hypoxia, the patient was placed on mechanical ventilation and admitted to the intensive care unit. Bronchoscopy was performed, and results revealed complete atelectasis with a soft tissue mass at the left main bronchus. Bronchoscopic biopsy confirmed that the patient's condition was endobronchial mucormycosis. Treatment with liposomal amphotericin B was started. After 1 week, atelectasis improved based on the chest radiography result. The patient was successfully extubated. However, 4 weeks after treatment, bronchoscopy still showed complete atelectasis with purulent secretion and a soft tissue mass. After 6 weeks, liposomal amphotericin B was switched to isavuconazole, with a duration of 2 months. After completing the treatment, bronchoscopy showed no endobronchial lesion. Herein, we present a rare case of rapidly progressing endobronchial mucormycosis in a young patient who did not have a previous history of any disease and who was successfully managed with pharmacological therapy.http://www.sciencedirect.com/science/article/pii/S2213007125000681Endobronchial mucormycosisAmphotericine BIsavuconazole |
| spellingShingle | Soo Kyun Jung Keum-Ju Choi Endobronchial mucormycosis successfully treated with pharmacologic therapy: A rare case report Respiratory Medicine Case Reports Endobronchial mucormycosis Amphotericine B Isavuconazole |
| title | Endobronchial mucormycosis successfully treated with pharmacologic therapy: A rare case report |
| title_full | Endobronchial mucormycosis successfully treated with pharmacologic therapy: A rare case report |
| title_fullStr | Endobronchial mucormycosis successfully treated with pharmacologic therapy: A rare case report |
| title_full_unstemmed | Endobronchial mucormycosis successfully treated with pharmacologic therapy: A rare case report |
| title_short | Endobronchial mucormycosis successfully treated with pharmacologic therapy: A rare case report |
| title_sort | endobronchial mucormycosis successfully treated with pharmacologic therapy a rare case report |
| topic | Endobronchial mucormycosis Amphotericine B Isavuconazole |
| url | http://www.sciencedirect.com/science/article/pii/S2213007125000681 |
| work_keys_str_mv | AT sookyunjung endobronchialmucormycosissuccessfullytreatedwithpharmacologictherapyararecasereport AT keumjuchoi endobronchialmucormycosissuccessfullytreatedwithpharmacologictherapyararecasereport |