miRNA regulation of the Akt/mTOR pathway in oral squamous cell carcinoma: a focused review
Abstract Oral squamous cell carcinoma (OSCC) contributes significantly to global cancer mortality, characterized by a progression from hyperplasia to invasive cancer through a series of genetic and epigenetic alterations. Central to this progression is the Akt/mTOR signaling pathway, which regulates...
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| Format: | Article |
| Language: | English |
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Springer
2025-07-01
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| Series: | Discover Oncology |
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| Online Access: | https://doi.org/10.1007/s12672-025-03073-2 |
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| author | Shazia Fathima Jaffer Hussain Mohammad Fareed Mohmed Isaqali Karobari |
| author_facet | Shazia Fathima Jaffer Hussain Mohammad Fareed Mohmed Isaqali Karobari |
| author_sort | Shazia Fathima Jaffer Hussain |
| collection | DOAJ |
| description | Abstract Oral squamous cell carcinoma (OSCC) contributes significantly to global cancer mortality, characterized by a progression from hyperplasia to invasive cancer through a series of genetic and epigenetic alterations. Central to this progression is the Akt/mTOR signaling pathway, which regulates cell proliferation and survival. This review examines the role of microRNAs (miRNAs) in modulating the Akt/mTOR pathway and their implications for OSCC. The Akt/mTOR pathway, activated by receptor tyrosine kinases and involving the PI3K/AKT/mTOR complexes, is crucial for tumor cell growth and metabolism. Dysregulation of this pathway is frequently observed in OSCC, leading to increased proliferation, survival, and metastasis. miRNAs, such as miR-21, miR-99, and miR-145, play significant roles in regulating this pathway by influencing key components like Akt and mTOR. These miRNAs can act as oncogenes or tumor suppressors, affecting cancer progression and response to therapy. The review highlights the potential of targeting miRNAs for OSCC treatment, including strategies to restore normal miRNA levels or inhibit aberrant miRNAs. Such targeted therapies offer promise for improving treatment outcomes and overcoming drug resistance in OSCC. Graphical abstract |
| format | Article |
| id | doaj-art-9e79f0ce10e241389833a3fcc3b9ce7c |
| institution | Kabale University |
| issn | 2730-6011 |
| language | English |
| publishDate | 2025-07-01 |
| publisher | Springer |
| record_format | Article |
| series | Discover Oncology |
| spelling | doaj-art-9e79f0ce10e241389833a3fcc3b9ce7c2025-08-20T04:03:06ZengSpringerDiscover Oncology2730-60112025-07-0116111310.1007/s12672-025-03073-2miRNA regulation of the Akt/mTOR pathway in oral squamous cell carcinoma: a focused reviewShazia Fathima Jaffer Hussain0Mohammad Fareed1Mohmed Isaqali Karobari2Global Research Cell, Dr. D. Y. Patil Dental College & Hospital, Dr. D. Y. Patil Vidyapeeth (Deemed to be University)Department of Basic Medical Sciences, College of Medicine, AlMaarefa UniversityDepartment of Conservative Dentistry and Endodontics, Saveetha Dental College and Hospitals, Saveetha Institute of Medical and Technical Sciences, Saveetha UniversityAbstract Oral squamous cell carcinoma (OSCC) contributes significantly to global cancer mortality, characterized by a progression from hyperplasia to invasive cancer through a series of genetic and epigenetic alterations. Central to this progression is the Akt/mTOR signaling pathway, which regulates cell proliferation and survival. This review examines the role of microRNAs (miRNAs) in modulating the Akt/mTOR pathway and their implications for OSCC. The Akt/mTOR pathway, activated by receptor tyrosine kinases and involving the PI3K/AKT/mTOR complexes, is crucial for tumor cell growth and metabolism. Dysregulation of this pathway is frequently observed in OSCC, leading to increased proliferation, survival, and metastasis. miRNAs, such as miR-21, miR-99, and miR-145, play significant roles in regulating this pathway by influencing key components like Akt and mTOR. These miRNAs can act as oncogenes or tumor suppressors, affecting cancer progression and response to therapy. The review highlights the potential of targeting miRNAs for OSCC treatment, including strategies to restore normal miRNA levels or inhibit aberrant miRNAs. Such targeted therapies offer promise for improving treatment outcomes and overcoming drug resistance in OSCC. Graphical abstracthttps://doi.org/10.1007/s12672-025-03073-2Oral squamous cell carcinomaAkt/mTOR signaling pathwayMicroRNAsCell proliferationCancer metastasisGenetic alterations |
| spellingShingle | Shazia Fathima Jaffer Hussain Mohammad Fareed Mohmed Isaqali Karobari miRNA regulation of the Akt/mTOR pathway in oral squamous cell carcinoma: a focused review Discover Oncology Oral squamous cell carcinoma Akt/mTOR signaling pathway MicroRNAs Cell proliferation Cancer metastasis Genetic alterations |
| title | miRNA regulation of the Akt/mTOR pathway in oral squamous cell carcinoma: a focused review |
| title_full | miRNA regulation of the Akt/mTOR pathway in oral squamous cell carcinoma: a focused review |
| title_fullStr | miRNA regulation of the Akt/mTOR pathway in oral squamous cell carcinoma: a focused review |
| title_full_unstemmed | miRNA regulation of the Akt/mTOR pathway in oral squamous cell carcinoma: a focused review |
| title_short | miRNA regulation of the Akt/mTOR pathway in oral squamous cell carcinoma: a focused review |
| title_sort | mirna regulation of the akt mtor pathway in oral squamous cell carcinoma a focused review |
| topic | Oral squamous cell carcinoma Akt/mTOR signaling pathway MicroRNAs Cell proliferation Cancer metastasis Genetic alterations |
| url | https://doi.org/10.1007/s12672-025-03073-2 |
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