TLR4/NF-κB-mediated M1 macrophage polarization contributes to the promotive effects of ETS2 on ulcerative colitis

TLR4/NF-κB-mediated M1 macrophage polarization contributes to the promotive effects of ETS2 on ulcerative colitis

Abstract Objective ETS2 is a core modulator of macrophages. This study aims to investigate the effects of ETS2 on macrophage polarization in ulcerative colitis (UC) and the involvement of TLR4/NF-κB pathway. Methods A dextran sulfate sodium (DSS)-induced acute UC mice model was established, along wi...

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Bibliographic Details
Main Authors: Binbin Liu, Jianshun Yu, Jie Zhang, Wei Ye, Jiaming Yao
Format: Article
Language:English
Published: BMC 2025-07-01
Series:European Journal of Medical Research
Subjects:
ETS2
Ulcerative colitis
Macrophage polarization
TLR4/NF-κB pathway
DSS-induced mice model
Online Access:https://doi.org/10.1186/s40001-025-02947-z
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