CTCF is selectively required for maintaining chromatin accessibility and gene expression in human erythropoiesis

CTCF is selectively required for maintaining chromatin accessibility and gene expression in human erythropoiesis

Abstract Background CTCF is considered as the most essential transcription factor regulating chromatin architecture and gene expression. However, genome-wide impact of CTCF on erythropoiesis has not been extensively investigated. Results Using a state-of-the-art human erythroid progenitor cell model...

Full description

Saved in:
Bibliographic Details
Main Authors: Xue Yang, Li Cheng, Ye Xin, Jianxiang Zhang, Xinfeng Chen, Jinchao Xu, Mengli Zhang, Ruopeng Feng, Judith Hyle, Wenjie Qi, Wojciech Rosikiewicz, Beisi Xu, Chunliang Li, Peng Xu
Format: Article
Language:English
Published: BMC 2025-02-01
Series:Genome Biology
Subjects:
CTCF
Chromatin accessibility
Transcription regulation
Hematopoiesis
Erythropoiesis
Genome editing
Online Access:https://doi.org/10.1186/s13059-025-03510-z
Tags: Add Tag
No Tags, Be the first to tag this record!
Be the first to leave a comment!
You must be logged in first

Similar Items