Premalignant and Malignant Skin Lesions in Two Recipients of Vascularized Composite Tissue Allografts (Face, Hands)
Recipients of solid organ transplants (RSOT) have a highly increased risk for developing cutaneous premalignant and malignant lesions, favored by the lifelong immunosuppression. Vascularized composite tissue allografts (VCA) have been introduced recently, and relevant data are sparse. Two patients w...
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| Format: | Article |
| Language: | English |
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Wiley
2015-01-01
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| Series: | Case Reports in Transplantation |
| Online Access: | http://dx.doi.org/10.1155/2015/356459 |
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| author | Jean Kanitakis Palmina Petruzzo Aram Gazarian Sylvie Testelin Bernard Devauchelle Lionel Badet Jean-Michel Dubernard Emmanuel Morelon |
| author_facet | Jean Kanitakis Palmina Petruzzo Aram Gazarian Sylvie Testelin Bernard Devauchelle Lionel Badet Jean-Michel Dubernard Emmanuel Morelon |
| author_sort | Jean Kanitakis |
| collection | DOAJ |
| description | Recipients of solid organ transplants (RSOT) have a highly increased risk for developing cutaneous premalignant and malignant lesions, favored by the lifelong immunosuppression. Vascularized composite tissue allografts (VCA) have been introduced recently, and relevant data are sparse. Two patients with skin cancers (one with basal cell carcinoma and one with squamous cell carcinomas) have been so far reported in this patient group. Since 2000 we have been following 9 recipients of VCA (3 face, 6 bilateral hands) for the development of rejection and complications of the immunosuppressive treatment. Among the 9 patients, one face-grafted recipient was diagnosed with nodular-pigmented basal cell carcinoma of her own facial skin 6 years after graft, and one patient with double hand allografts developed disseminated superficial actinic porokeratosis, a potentially premalignant dermatosis, on her skin of the arm and legs. Similar to RSOT, recipients of VCA are prone to develop cutaneous premalignant and malignant lesions. Prevention should be applied through sun-protective measures, regular skin examination, and early treatment of premalignant lesions. |
| format | Article |
| id | doaj-art-9e5fb5f0bca646e2a04edfe6eca19019 |
| institution | Kabale University |
| issn | 2090-6943 2090-6951 |
| language | English |
| publishDate | 2015-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Case Reports in Transplantation |
| spelling | doaj-art-9e5fb5f0bca646e2a04edfe6eca190192025-08-20T03:38:43ZengWileyCase Reports in Transplantation2090-69432090-69512015-01-01201510.1155/2015/356459356459Premalignant and Malignant Skin Lesions in Two Recipients of Vascularized Composite Tissue Allografts (Face, Hands)Jean Kanitakis0Palmina Petruzzo1Aram Gazarian2Sylvie Testelin3Bernard Devauchelle4Lionel Badet5Jean-Michel Dubernard6Emmanuel Morelon7Department of Dermatology, Edouard Herriot Hospital Group, 69003 Lyon, FranceDepartment of Surgery, University of Cagliari, 09124 Cagliari, ItalyHand Surgery Department, Clinique du Parc, 69006 Lyon, FranceDepartment of Maxillofacial Surgery and Stomatology, University Hospital Nord, 80054 Amiens, FranceDepartment of Maxillofacial Surgery and Stomatology, University Hospital Nord, 80054 Amiens, FranceDepartment of Transplantation, Edouard Herriot Hospital Group, 69003 Lyon, FranceDepartment of Transplantation, Edouard Herriot Hospital Group, 69003 Lyon, FranceDepartment of Transplantation, Edouard Herriot Hospital Group, 69003 Lyon, FranceRecipients of solid organ transplants (RSOT) have a highly increased risk for developing cutaneous premalignant and malignant lesions, favored by the lifelong immunosuppression. Vascularized composite tissue allografts (VCA) have been introduced recently, and relevant data are sparse. Two patients with skin cancers (one with basal cell carcinoma and one with squamous cell carcinomas) have been so far reported in this patient group. Since 2000 we have been following 9 recipients of VCA (3 face, 6 bilateral hands) for the development of rejection and complications of the immunosuppressive treatment. Among the 9 patients, one face-grafted recipient was diagnosed with nodular-pigmented basal cell carcinoma of her own facial skin 6 years after graft, and one patient with double hand allografts developed disseminated superficial actinic porokeratosis, a potentially premalignant dermatosis, on her skin of the arm and legs. Similar to RSOT, recipients of VCA are prone to develop cutaneous premalignant and malignant lesions. Prevention should be applied through sun-protective measures, regular skin examination, and early treatment of premalignant lesions.http://dx.doi.org/10.1155/2015/356459 |
| spellingShingle | Jean Kanitakis Palmina Petruzzo Aram Gazarian Sylvie Testelin Bernard Devauchelle Lionel Badet Jean-Michel Dubernard Emmanuel Morelon Premalignant and Malignant Skin Lesions in Two Recipients of Vascularized Composite Tissue Allografts (Face, Hands) Case Reports in Transplantation |
| title | Premalignant and Malignant Skin Lesions in Two Recipients of Vascularized Composite Tissue Allografts (Face, Hands) |
| title_full | Premalignant and Malignant Skin Lesions in Two Recipients of Vascularized Composite Tissue Allografts (Face, Hands) |
| title_fullStr | Premalignant and Malignant Skin Lesions in Two Recipients of Vascularized Composite Tissue Allografts (Face, Hands) |
| title_full_unstemmed | Premalignant and Malignant Skin Lesions in Two Recipients of Vascularized Composite Tissue Allografts (Face, Hands) |
| title_short | Premalignant and Malignant Skin Lesions in Two Recipients of Vascularized Composite Tissue Allografts (Face, Hands) |
| title_sort | premalignant and malignant skin lesions in two recipients of vascularized composite tissue allografts face hands |
| url | http://dx.doi.org/10.1155/2015/356459 |
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