Short-term predictive value of sST2 in patients with STEMI following primary PCI: a prospective observational study
Abstract Aim The objective of this study was to investigate the level of soluble suppression of tumorigenicity-2 (sST2) in patients with acute ST-segment elevation myocardial infarction (STEMI) following primary percutaneous coronary intervention (PCI), and to provide a new biomarker for clinical ma...
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| Language: | English |
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BMC
2025-01-01
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| Series: | BMC Cardiovascular Disorders |
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| Online Access: | https://doi.org/10.1186/s12872-025-04488-z |
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| author | Shan Huang Lu-Jiao Yu Guang-Feng Sun Zi-Xin Zhang |
| author_facet | Shan Huang Lu-Jiao Yu Guang-Feng Sun Zi-Xin Zhang |
| author_sort | Shan Huang |
| collection | DOAJ |
| description | Abstract Aim The objective of this study was to investigate the level of soluble suppression of tumorigenicity-2 (sST2) in patients with acute ST-segment elevation myocardial infarction (STEMI) following primary percutaneous coronary intervention (PCI), and to provide a new biomarker for clinical management and prognosis assessment. Method This was a prospective study. 148 STEMI patients following primary PCI were enrolled and divided into 2 groups by the median value of sST2 and afterwards followed up for 30 days to access the occurrence of major adverse cardiac events (MACEs), which were defined as cardiovascular death, heart failure and recurrent MI. Results sST2 ranged from 20.57 to 98.96 ng/mL. High sST2 group had higher MACEs rate compared to low sST2 group (28.8% vs. 8.0%, P = 0.001). sST2 was positively correlated with age (r = 0.181, P = 0.027), SYNTAX score (r = 0.257, P = 0.002), high-sensitive C-reactive protein (hs-CRP) (r = 0.225, P = 0.006), B-type natriuretic peptide (BNP) (r = 0.225, P = 0.006) and negatively with left ventricle ejection fraction (LVEF) (r = -0.197, P = 0.016). After adjustment for clinical variables, sST2 level (OR 3.680, P = 0.015) and LVEF (OR 0.880, P < 0.001) remained independent predictors of 30-days MACEs. In receiver operating characteristic curve (ROC) analyses, the area under the curve (AUC) of sST2 for predicting 30-days MACEs was 0.755(P < 0.001). The AUC of sST2 combining hs-CRP and LVEF for prediction was 0.828(95%CI [0.743–0.912], P < 0.001). Conclusion sST2 level after primary PCI was an independent risk factor of MACEs in STEMI patients through 30 days follow-up. |
| format | Article |
| id | doaj-art-9e5f940d80bf4b4dbe7897616b19da26 |
| institution | Kabale University |
| issn | 1471-2261 |
| language | English |
| publishDate | 2025-01-01 |
| publisher | BMC |
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| series | BMC Cardiovascular Disorders |
| spelling | doaj-art-9e5f940d80bf4b4dbe7897616b19da262025-01-19T12:09:23ZengBMCBMC Cardiovascular Disorders1471-22612025-01-012511810.1186/s12872-025-04488-zShort-term predictive value of sST2 in patients with STEMI following primary PCI: a prospective observational studyShan Huang0Lu-Jiao Yu1Guang-Feng Sun2Zi-Xin Zhang3Department of Cardiology, School of Medicine, Xiamen Cardiovascular Hospital of Xiamen University, Xiamen UniversityDepartment of Geriatrics, the First Hospital of China Medical UniversityDepartment of Emergency, School of Medicine, Xiamen Cardiovascular Hospital of Xiamen University, Xiamen UniversityDepartment of Cardiology, the First Hospital of China Medical UniversityAbstract Aim The objective of this study was to investigate the level of soluble suppression of tumorigenicity-2 (sST2) in patients with acute ST-segment elevation myocardial infarction (STEMI) following primary percutaneous coronary intervention (PCI), and to provide a new biomarker for clinical management and prognosis assessment. Method This was a prospective study. 148 STEMI patients following primary PCI were enrolled and divided into 2 groups by the median value of sST2 and afterwards followed up for 30 days to access the occurrence of major adverse cardiac events (MACEs), which were defined as cardiovascular death, heart failure and recurrent MI. Results sST2 ranged from 20.57 to 98.96 ng/mL. High sST2 group had higher MACEs rate compared to low sST2 group (28.8% vs. 8.0%, P = 0.001). sST2 was positively correlated with age (r = 0.181, P = 0.027), SYNTAX score (r = 0.257, P = 0.002), high-sensitive C-reactive protein (hs-CRP) (r = 0.225, P = 0.006), B-type natriuretic peptide (BNP) (r = 0.225, P = 0.006) and negatively with left ventricle ejection fraction (LVEF) (r = -0.197, P = 0.016). After adjustment for clinical variables, sST2 level (OR 3.680, P = 0.015) and LVEF (OR 0.880, P < 0.001) remained independent predictors of 30-days MACEs. In receiver operating characteristic curve (ROC) analyses, the area under the curve (AUC) of sST2 for predicting 30-days MACEs was 0.755(P < 0.001). The AUC of sST2 combining hs-CRP and LVEF for prediction was 0.828(95%CI [0.743–0.912], P < 0.001). Conclusion sST2 level after primary PCI was an independent risk factor of MACEs in STEMI patients through 30 days follow-up.https://doi.org/10.1186/s12872-025-04488-zSoluble suppression of tumorigenicity-2Acute ST-elevation myocardial infarctionPrimary percutaneous coronary interventionMajor adverse cardiac events |
| spellingShingle | Shan Huang Lu-Jiao Yu Guang-Feng Sun Zi-Xin Zhang Short-term predictive value of sST2 in patients with STEMI following primary PCI: a prospective observational study BMC Cardiovascular Disorders Soluble suppression of tumorigenicity-2 Acute ST-elevation myocardial infarction Primary percutaneous coronary intervention Major adverse cardiac events |
| title | Short-term predictive value of sST2 in patients with STEMI following primary PCI: a prospective observational study |
| title_full | Short-term predictive value of sST2 in patients with STEMI following primary PCI: a prospective observational study |
| title_fullStr | Short-term predictive value of sST2 in patients with STEMI following primary PCI: a prospective observational study |
| title_full_unstemmed | Short-term predictive value of sST2 in patients with STEMI following primary PCI: a prospective observational study |
| title_short | Short-term predictive value of sST2 in patients with STEMI following primary PCI: a prospective observational study |
| title_sort | short term predictive value of sst2 in patients with stemi following primary pci a prospective observational study |
| topic | Soluble suppression of tumorigenicity-2 Acute ST-elevation myocardial infarction Primary percutaneous coronary intervention Major adverse cardiac events |
| url | https://doi.org/10.1186/s12872-025-04488-z |
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