Obeticholic acid ameliorates sepsis-induced renal mitochondrial damage by inhibiting the NF-κb signaling pathway

Obeticholic acid ameliorates sepsis-induced renal mitochondrial damage by inhibiting the NF-κb signaling pathway

Acute kidney injury (AKI), a common complication of sepsis, might be caused by overactivated inflammation, mitochondrial damage, and oxidative stress. However, the mechanisms underlying sepsis-induced AKI (SAKI) have not been fully elucidated, and there is a lack of effective therapies for AKI. To t...

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Bibliographic Details
Main Authors: Danyang Jing, Jingfeng Liu, Da Qin, Jin Lin, Tian Li, Yu Li, Meili Duan
Format: Article
Language:English
Published: Taylor & Francis Group 2024-12-01
Series:Renal Failure
Subjects:
Sepsis
AKI
inflammation
mitochondria
OCA
Online Access:https://www.tandfonline.com/doi/10.1080/0886022X.2024.2368090
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