The impact of advanced proteomics in the search for markers and therapeutic targets of bladder cancer
Bladder cancer is the most common cancer of the urinary tract and can be avoided through proper surveillance and monitoring. Several genetic factors are known to contribute to the progression of bladder cancer, many of which produce molecules that serve as cancer biomarkers. Blood, urine, and tissue...
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| Format: | Article |
| Language: | English |
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SAGE Publishing
2017-03-01
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| Series: | Tumor Biology |
| Online Access: | https://doi.org/10.1177/1010428317691183 |
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| author | Hongshuo Zhang Yue Fan Lingling Xia Chunhui Gao Xin Tong Hanfu Wang Lili Sun Tuo Ji Mingyu Jin Bing Gu Bo Fan |
| author_facet | Hongshuo Zhang Yue Fan Lingling Xia Chunhui Gao Xin Tong Hanfu Wang Lili Sun Tuo Ji Mingyu Jin Bing Gu Bo Fan |
| author_sort | Hongshuo Zhang |
| collection | DOAJ |
| description | Bladder cancer is the most common cancer of the urinary tract and can be avoided through proper surveillance and monitoring. Several genetic factors are known to contribute to the progression of bladder cancer, many of which produce molecules that serve as cancer biomarkers. Blood, urine, and tissue are commonly analyzed for the presence of biomarkers, which can be derived from either the nucleus or the mitochondria. Recent advances in proteomics have facilitated the high-throughput profiling of data generated from bladder cancer–related proteins or peptides in parallel with high sensitivity and specificity, providing a wealth of information for biomarker discovery and validation. However, the transmission of screening results from one laboratory to another remains the main disadvantage of these methods, a fact that emphasizes the need for consistent and standardized procedures as suggested by the Human Proteome Organization. This review summarizes the latest discoveries and progress of biomarker identification for the early diagnosis, projected prognosis, and therapeutic response of bladder cancer, informs the readers of the current status of proteomic-based biomarker findings, and suggests avenues for future work. |
| format | Article |
| id | doaj-art-9e563c1793324dd9897877bfd5b33e77 |
| institution | DOAJ |
| issn | 1423-0380 |
| language | English |
| publishDate | 2017-03-01 |
| publisher | SAGE Publishing |
| record_format | Article |
| series | Tumor Biology |
| spelling | doaj-art-9e563c1793324dd9897877bfd5b33e772025-08-20T02:51:31ZengSAGE PublishingTumor Biology1423-03802017-03-013910.1177/1010428317691183The impact of advanced proteomics in the search for markers and therapeutic targets of bladder cancerHongshuo Zhang0Yue Fan1Lingling Xia2Chunhui Gao3Xin Tong4Hanfu Wang5Lili Sun6Tuo Ji7Mingyu Jin8Bing Gu9Bo Fan10Department of Biochemistry, Institute of Glycobiology, Dalian Medical University, Dalian, P.R. ChinaDepartment of Propaganda, Jinzhou Medical University, Jinzhou, P.R. ChinaShenzhen Key Laboratory of Genitourinary Tumor, Shenzhen Second People’s Hospital, First Affiliated Hospital of Shenzhen University, Shenzhen, P.R. ChinaDepartment of Gastrointestinal Surgery, The Affiliated Cancer Hospital of Guangzhou Medical University, Guangzhou, P.R. ChinaDepartment of Gastrointestinal Surgery, The First Affiliated Hospital of Jinzhou Medical University, Jinzhou, P.R. ChinaMedical Department, The First Affiliated Hospital of Jinzhou Medical University, Jinzhou, P.R. ChinaDepartment of Ophthalmology, The Third Affiliated Hospital of Jinzhou Medical University, Jinzhou, P.R. ChinaDepartment of Hospital Management, Jinzhou Medical University, Jinzhou, P.R. ChinaGraduate School, Dalian Medical University, Dalian, P.R. ChinaDepartment of Laboratory Medicine, Affiliated Hospital of Xuzhou Medical University, Xuzhou, P.R. ChinaDepartment of Urology, Second Affiliated Hospital, Dalian Medical University, Dalian, P.R. ChinaBladder cancer is the most common cancer of the urinary tract and can be avoided through proper surveillance and monitoring. Several genetic factors are known to contribute to the progression of bladder cancer, many of which produce molecules that serve as cancer biomarkers. Blood, urine, and tissue are commonly analyzed for the presence of biomarkers, which can be derived from either the nucleus or the mitochondria. Recent advances in proteomics have facilitated the high-throughput profiling of data generated from bladder cancer–related proteins or peptides in parallel with high sensitivity and specificity, providing a wealth of information for biomarker discovery and validation. However, the transmission of screening results from one laboratory to another remains the main disadvantage of these methods, a fact that emphasizes the need for consistent and standardized procedures as suggested by the Human Proteome Organization. This review summarizes the latest discoveries and progress of biomarker identification for the early diagnosis, projected prognosis, and therapeutic response of bladder cancer, informs the readers of the current status of proteomic-based biomarker findings, and suggests avenues for future work.https://doi.org/10.1177/1010428317691183 |
| spellingShingle | Hongshuo Zhang Yue Fan Lingling Xia Chunhui Gao Xin Tong Hanfu Wang Lili Sun Tuo Ji Mingyu Jin Bing Gu Bo Fan The impact of advanced proteomics in the search for markers and therapeutic targets of bladder cancer Tumor Biology |
| title | The impact of advanced proteomics in the search for markers and therapeutic targets of bladder cancer |
| title_full | The impact of advanced proteomics in the search for markers and therapeutic targets of bladder cancer |
| title_fullStr | The impact of advanced proteomics in the search for markers and therapeutic targets of bladder cancer |
| title_full_unstemmed | The impact of advanced proteomics in the search for markers and therapeutic targets of bladder cancer |
| title_short | The impact of advanced proteomics in the search for markers and therapeutic targets of bladder cancer |
| title_sort | impact of advanced proteomics in the search for markers and therapeutic targets of bladder cancer |
| url | https://doi.org/10.1177/1010428317691183 |
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